The London Metallomics Facility is a central hub for advanced metallomic analytics, promoting interaction between diverse areas of academic research, industry, and equipment manufacturers. It also plays a key role in education and training within this emerging field, providing necessary expertise and support to researchers.

Awards

• London Metallomics Facility - Wellcome Trust Multi-user Equipment Grant

• Metallomic profiling and redox signalling in human coronary artery endothelial and smooth muscle cells in physiological normoxia and ischaemia/reperfusion injury - Heart Research UK

• Multidimensional Metallomic Imaging for Environmental Hazard Analysis - Natural Environment Research Council

• PET metallomics in cancer: predicting response to platinum drugs - Medical Research Council

• Metallomic Profiling and Imaging for Understanding Skin and Scalp Biology - BBSRC LIDo

• Metal Fingerprints in Normal Cell States and Disease - King's Together Strategic Award

• Integrated multi-modal tissue state mapping of TNBC progression- 

2024 Publications

Kaasalainen, M., Zhang, R., Vashisth, P., Ahmadi Birjandi, A., S'Ari, M., Martella, D., Isaacs, M., Makila, E., Wang, C., Moldenhauer, E., Clarke, P., Pinna, A., Zhang, X., Mustfa, S. A., Caprettini, V., Morrell, A., Gentleman, E., Brauer, D. S., Addison, O., Zhang, X. Bergholt, M., Al-Jamal, K., Volponi, A. A., Salonen, J., Hondow, N., Sharpe, P., Chiappini, C., (2024) Lithiated porous silicon nanowires stimulate periodontal regeneration, Nature Communications 15, 487 (2024)

2023 Publications

Boer, L. Melgrati, S. Vanes, L. O'May J. Hayward, D. Koechl, R. Driscoll, P. MacRae, J. Day, J. Griffiths, A. Magueta, R. Morrell, A. Tybulewicz, V., (2024) T cell migration requires ion and water influx to regulate actin polymerization, Nature Communications 14, 7844 (2023)

Afnan, D. Imberti, C. Bartnicka, J. Al-Salemee, F. Blower, J. Rigby, A. Bordoloi, J. Griffiths, A. Ma, M. Blower, P., (2023) In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging, 10.3390/Molecules/28207217

Smith M.J, Yang F, Griffiths A, Morrell A, Chapple S.J, Siow R.C.M, Stewart T, Maret, W, and Mann, G.E (2023) Redox and metal profiles in human coronary endothelial and smooth muscle cells under hyperoxia, physiological normoxia and hypoxia: effects of NRF2 signaling on intracellular zinc, j.redox.2023.102712.

Han S, Wang J.T-W, Yavuz E, Zam A, Rouatbi N, Utami R.N, Liam-Or, R, Griffiths A., Dickson W, Sosabowski J, Al-Jamal K.T, (2023). Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting, j.jconrel.2023.04.022.

Weston A, Vladescu S.C, Reddyhoff T, Griffiths A., Crouzier T., Fielden M, Garnett J.A, Carpenter G.H, (2023). The Influence of Ions on the Lubricative Abilities of Mucin and the Role of Sialic Acids, j.colsurfb.2023.113327.

Firth G, Georgiadou E, Griffiths A, Amrahli M, Kim J, Yu Z, Hu M, Stewart T, Leclerc I, Okamoto H, Gomez D, Blower P.J, Rutter G.A, (2023). Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice, fendo.2023.1171933.

Yang F, Smith M.J, Griffiths A, Morrell A, Chapple S.J, Siow R.C.M, Stewart T., Maret W, Mann G.E, (2023). Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signalling under hypoxia/reoxygenation, j.redox.2023.102777.

Morrell A.P, Martin R.M, Roberts H.M, Castillo-Michel H., Mosselmans J.F.W, Geraki K, Warfield A.T, Lingor P, Qayyum W, Graf D, Febbraio M, Addison O, (2023). Addressing uncertainties in correlative imaging of exogenous particles with the tissue microanatomy with synchronous imaging strategies, mfad030.

2022 Publications 

Wan Y, Stewart T, Amrahli M, Evans J, Sharp P, Govindan V, Hawkesford MJ, Shewry PR, (2022) Localisation of iron and zinc in grain of biofortified wheat, J. Cereal Sci. in press.

2021 Publications

Goncalves J., Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J (2021) Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate, Cancer Res. 81:3480–3494.

Unosson J, Kabéle M, Boman C, Nyström R, Sadiktsis I, Westerholm R, Mudway IS, Purdie E, Raftis J, Miller MR, Mills NL, Newby DE, Blomberg A, Sandström T, Bosson JA (2021) Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study. Part Fibre Toxicol. 18:22.

Osytek KM, Blower PJ, Costa IM, Smith GE, Abbate V, Terry SYA (2021) In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201 EJNMMI Res 11: 63.

Alaohali A, Brauer DS, Gentleman E, Sharpe PT (2021) A modified glass ionomer cement to mediate dentine repair Dental Materials 37:1307-1315.

Frangos T, Maret W (2021) Zinc and Cadmium in the Aetiology and Pathogenesis of Osteoarthritis and Rheumatoid Arthritis. Nutrients. 13:53.

2020 Publications

Ashraf A, Jeandriens J, Parkes HG, So PW (2020) Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox Biology 32:101494.

Kutscher D, Asogan D, Mudway I, Brekke P, Beales C, Wang X, Perkins M, Maret W, Stewart T (2020) Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New Applications Spectroscopy 35:16–26.

Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C (2020) The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. J. Trace Elem. Med. Biol. 60:126496.

Selley L, Schuster L, Marbach H, Forsthuber T, Forbes B, Gant TW, Sandstrom T, Camina N, Athersuch TJ, Mudway I, Kumar A (2020) Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages. Metallomics. 12:371-386.

2019 Publications

Fitzgerald JA, Urbina MG, Rogers NJ, Bury NR, Katsiadaki I, Wilson RW, Santos EM (2019) Sublethal exposure to copper supresses the ability to acclimate to hypoxia in a model fish species. Aquatic Toxicology 217:105325.

Stewart TJ (2019) Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging. Metallomics. 11:29–49.

Zhang K, Alaohali A, Sawangboon N, Sharpe PT, Brauer DS, Gentleman E (2019) A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair Dental Materials 35: 919-927.

Maret W (2019) The redox biology of redox-inert zinc ions. Free Radic Biol Med. 134:311-326.

Koppenol WH, Hider R (2019) Iron and redox cycling. Do's and don'ts. Free Radic Biol Med. 133:3-10.

Kose T, Vera-Aviles M, Sharp PA, Latunde-Dada GO (2019) Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells against Iron Toxicity and Erastin-Induced Ferroptosis Pharmaceuticals. 12: 26.

Ashraf A, Stosnach H, Parkes HG, Hye A, Powell J, So PW (2019) Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer’s Disease. Scientific Reports 9:3147.

Cusnir R, Cakebread A, Cooper MS, Young JD, Blower PJ, Ma MT (2019) The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator RSC Advances 9: 37214-37221.

Lawson R, Maret W, Hogstrand C (2019) ZnT8 Haploinsufficiency Impacts MIN6 cell zinc content and β-cell phenotype via ZIP-ZnT8 coregulation Int. J. Mol. Sci. 21:5485.

2018 Publications

Pfeffer PE, Lu H, Mann EH, Chen YH, Ho TR, Cousins DJ, Corrigan C, Kelly FJ, Mudway IS, Hawrylowicz CM (2018) Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter. PLoS One 8:e0200040.

Prabhu PAJ, Stewart T, Silva M, Amlund H, Ørnsrud, R, Lock EJ, Waagbo R, Hogstrand C (2018) Zinc uptake in fish intestinal epithelial model RTgutGC: Impact of media ion composition and methionine chelation J Trace Elem Med Biol. 50:377-383.

Lawson R, Maret W, Hogstrand C (2018) Prolonged stimulation of insulin release from MIN6 cells causes zinc depletion and loss of β-cell markers J Trace Elem Med Biol. 49: 51-59.

Parsons D, Hogstrand C, Maret W (2018) The C-terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant FEBS Journal 285: 1237-1250.

Maret W (2018) Metallomics: The Science of Biometals and Biometalloids. Adv Exp Med Biol. 1055:1-20.

Bartnika JJ, Blower PJ (2018) Insights into Trace Metal Metabolism in Health and Disease from PET: PET Metallomics. J Nucl Med. 59:1355-1359.

Miyashita L, Suri R, Dearing E, Mudway I, Dove RE, Neill DR, Van Zyl-Smit R, Kadioglu A, Grigg J (2018) E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. Eur Respir J. 51:1701592.

Jarvis IWH, Enlo-Scott Z, Nagy E, Mudway IS, Tetley TD, Arlt VM, Phillips DH (2018) Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells. Environ Mol Mutagen. 59:290-301.

2017 Publications 

Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MG (2017) Mechanistic link between diesel exhaust particles and respiratory reflexes. J Allergy Clin Immunol. 141:1074-1084.

Mann EH, Ho TR, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM (2017) Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 57:355-366.

Tsionou MI, Knapp CE, Foley CA, Munteanu CR, Cakebread A, Imberti C, Eykyn TR, Young JD, Paterson BM, Blower PJ, Ma MT (2017) Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling RSC Advances 7: 49586-49599.

da Silva JG, Babb R, Salzlechner C, Sharpe PT, Brauer DS, Gentleman E (2017) Optimisation of lithium-substituted bioactive glasses to tailor cell response for hard tissue repair Journal of Materials Science 52: 8832–8844.

2016 Publications 

Samoli E, Atkinson RW, Analitis A, Fuller GW, Beddows D, Green DC, Mudway IS, Harrison RM, Anderson HR, Kelly FJ (2016) Differential health effects of short-term exposure to source-specific particles in London, UK. Environ Int. 97:246-253.

Atkinson RW, Samoli E, Analitis A, Fuller GW, Green DC, Anderson HR, Purdie E, Dunster C, Aitlhadj L, Kelly FJ, Mudway IS (2016) Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London Int J Hyg Environ Health. 219:566-572.

Samoli E, Atkinson RW, Analitis A, Fuller GW, Green DC, Mudway I, Anderson HR, Kelly FJ (2016) Associations of short-term exposure to traffic-related air pollution with cardiovascular and respiratory hospital admissions in London, UK Occup Environ Med. 73:300-307.

Atkinson RW, Analitis A, Samoli E, Fuller GW, Green DC, Mudway IS, Anderson HR, Kelly FJ (2016) Short-term exposure to traffic-related air pollution and daily mortality in London UK 26:125–132.

Suri R, Periselneris J, Lanone S, Zeidler-Erdely PC, Melton G, Palmer KT, Andujar P, Antonini JM, Cohignac V, Erdely A, Jose RJ, Mudway I, Brown J, Grigg J (2016) Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae. J Allergy Clin Immunol. 137:527-534.