The Single Cell Omics Platform (SCOP) is a state-of-the-art facility based at New Hunts House, King’s College London. It is equipped with advanced instrumentation and supported by a team of highly experienced scientists with many years of expertise in single-cell omics. The SCOP team is dedicated to delivering high-quality, flexible services tailored to the needs of the KCL research community.
SCOP specialises in a broad range of single-cell and single-nucleus technologies, including:
-
10x Genomics assays – including 3′ Gene Expression, 5′ Gene Expression and V(D)J, Multiome ATAC, GEM-X Flex, and OCM (on-chip multiplexing) using the 10x Chromium X platform, enabling high-throughput, multimodal single-cell profiling.
-
BD Rhapsody – a microwell-based single-cell platform ideal for targeted gene expression and immune profiling, offering flexibility in experimental design and compatibility with low-input or precious samples.
-
Parse Biosciences – a combinatorial barcoding approach that enables scalable, fixation-friendly single-cell RNA sequencing without the need for specialised instrumentation, making it well suited for large or complex experimental designs.
-
PIP-Seq (Illumina) – a plate-based single-cell RNA-seq method providing high sensitivity and full-length transcript coverage, particularly useful for detailed transcriptomic analyses and method development.
-
ddSEQ (Bio-Rad) – a droplet-based single-cell system offering robust and reproducible gene expression profiling, well suited for smaller-scale projects or exploratory single-cell studies.
As an integral part of King’s College London, SCOP is proudly supported by the Hayday Group, Taams Lab, Martinez-Nunez Group, Tree Group, and the School of Immunology & Microbial Science (SIMS). This strong institutional backing reinforces our commitment to excellence, collaboration, and innovation in cutting-edge single-cell research.
Single-Cell Sequencing
We offer end-to-end single-cell sequencing services, from library preparation to FASTQ data delivery, using multiple cutting-edge platforms:
10x Genomics (Chromium X)
Assays: 3′ Gene Expression, 5′ Gene Expression, V(D)J - TCR/BCR, Multiome ATAC, GEM-X Flex, OCM (on-chip multiplexing)
Application: High-throughput single-cell RNA-seq, immune profiling, and multimodal analysis combining gene expression and chromatin accessibility
BD Rhapsody
Assays: Targeted gene expression, immune profiling panels
Application: Rare cell populations, low-input samples, and targeted gene panels.
Parse Biosciences
Assays: Combinatorial barcoding RNA-seq
Application: Large-scale transcriptomic studies, compatible with fixed or frozen samples.
PIP-Seq (Illumina)
Assays: Plate-based full-length RNA-seq
Application: Detailed transcriptomic analyses, isoform detection, and method development.
ddSEQ (Bio-Rad)
Assays: Single-Cell 3′ RNA-Seq Kit (gene expression) and Single-Cell ATAC-Seq Kit (chromatin accessibility)
Application: Gene expression profiling for small- to medium-scale studies; single-cell ATAC-seq for profiling regulatory landscapes and cell identity.
Consulting and Training
We provide expert consulting on experimental design, platform selection, and assay optimisation for any budget or starting material, offering personalised guidance throughout your single-cell sequencing projects.
We also offer trial runs to assess cell quality and quantity before committing to full experiments, along with training workshops and seminars to equip researchers with the skills needed to perform single-cell omics research effectively.
Open access equipment
Our facility provides open access to state-of-the-art equipment for single-cell research. Induction and training are provided, and we can advise on access, scheduling, and costs. Please contact us for more information.
Collaboration
We welcome collaborations on projects exploring new methods or pipelines. For ‘out-of-catalogue’ requests or custom experiments, please get in touch to discuss your ideas.
Facility staff
Manager
Technician
Affiliated academics
Professor of Immunobiology
Head of the School of Immunology & Microbial Sciences
Reader in RNA Biology and Immunity
Professor of Immune Regulation and Immunotherapy
Our facility offers open access to state-of-the-art equipment for single-cell research. Induction and training provided. Please contact the SCOP facility single-cell-facility@kcl.ac.uk regarding access, training and costing.
Related equipment
10x Chromium X, 10x Genomics
Chromium X offers cost-effective, lower throughput single cell analysis
4200 TapeStation System, Agilent
High-throughput automated electrophoresis, allows fully automated, easy, and reliable analysis of DNA and RNA samples for up to 96 samples per run.
CellDrop FL, DeNovix
Automated Cell Counter
Qubit™ Flex Fluorometer, Invitrogen™
Fast, accurate DNA, RNA, and protein quantification up to eight samples
BD Rhapsody™ HT Xpress System and Scanner
The BD Rhapsody™ HT Xpress System – a microwell-based single-cell platform for targeted gene expression and immune profiling
2025
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
A Lock, EM Drudi, D Freydina, BM Stramer, F Denk… - bioRxiv, 2025 - biorxiv.org
P31 Single-cell RNA sequencing reveals transcriptional changes induced by cell passage in keloid and normal skin derived stromal cells
A Lock-Soper, D Freydina, F Denk… - British Journal of …, 2026 - academic.oup.com
Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids
G Goss, A Torres-Cano, M Pedna, H Wilson, M Simon… - bioRxiv, 2025 - biorxiv.org
Upcoming events
28th May 2025 - Single-Cell Analysis Workshop
The Single Cell Omics Platform is organising a workshop in collaboration with Nygen. If you’re interested, please find below the registration link for the Single-Cell Analysis Workshop, taking place on 28 May 2025, from 10:00 to 12:30.
The workshop is free to attend, but places are limited, so early registration is recommended.
Please note: participants are required to bring their own laptops for the hands-on session.
Please feel free to share this event with your colleagues. If you’re no longer able to attend, kindly let me know.
--------------------------------
The Single Cell Omics Platform (SCOP) is excited to announce a series of mini seminars on single-cell techniques, new approaches, and innovations in the field.
12th June 2025
You are warmly invited to attend an upcoming SCOP seminar focused on Single Cell and Spatial Technologies, bringing together users and industry representatives for a day of knowledge-sharing and discussion.
🗓 Date: 12th June 2025
🕙 Time: 10am - 12.30pm
📍 Location: Guy's New Hunts House, Room G.8 (Ground Floor)
Draft Agenda (TBC):
-
Introduction – SCOP
-
Company Presentations
-
Two short talks (~20 mins each) from 10x Genomics and Cell Signaling Technology (CST)
-
-
Research Presentations
-
Four short talks (10 mins + 5 mins Q&A) from SCOP users, scheduled between the company sessions
-
-
Lunch & Informal Discussion – An opportunity to network and continue the conversation
We’re aiming for a relatively informal format with plenty of opportunity for interaction and engagement throughout the day.
Confirmed Speakers So Far:
-
Onofrio Zanin (Martinez Group): Single Cell Profiling of Airway Samples in Severe Asthma
-
Cara Brown (Hayday Group): Gamma Delta Transcriptomics
-
TBC: GEM-X Flex Assay
-
TBC: On-Chip Multiplexing Assay
We hope you can join us for what promises to be an insightful and collaborative session.
Archive
2023
Established in September 2023, the Single Cell Omics Platform (SCOP) aims to provide state-of-the-art facilities and expert support to researchers interested in single-cell omics analyses. With support from esteemed research groups including the Hayday Group, Taams Lab, Martinez-Nunez group, Inflammation Biology Group, Tree Group, and the School of Immunology & Microbial Science (SIMS), SCOP is dedicated to advancing single-cell research and fostering collaboration within the scientific community.
2024
29th May 2024
I am pleased to invite you to a seminar on "Single Cell Sample Prep and Product Updates" sponsored by 10x Genomics, in collaboration with the Single Cell Omics Platform (SCOP).
Date: Wednesday, 29th May 2024
Time: 9:30 am - 11:10 am
Venue: Room G12 - Ground floor at New Hunt's House (Guy's Campus, SE1 1UL) and Hybrid – MS Teams (Join the meeting now)
AGENDA:
9:30 am - Welcome (5 min) - Dasha Freydina, SCOP
9:35 am - Sample preparation: designing your single-cell experiment (35 min) & Q&A (10 min) - Carla Botas, 10x Genomics
10:15 am - Coffee break (15 min)
10:30 am - Product technical updates (30 min) & Q&A (10 min) - Carla Botas, 10x Genomics
-
GEM-X: New 5' and 3' Single Cell Chemistry
-
Flex assay: technical overview of our Fix assay
-
Single Cell Multiome ATAC and Gene Expression
11:10 am - Wrap up - Dasha Freydina, SCOP
This seminar promises valuable insights into sample preparation techniques for single-cell experiments and updates on the latest products and technologies from 10X Genomics. It's an excellent opportunity to enhance your knowledge and network with others doing single cell work and industry professionals.
Please register using the Link (not working anymore) to secure your place. Should you have any questions or require further information, feel free to reach out.
------------------------
31st October 2024
The Single Cell Omics Platform (SCOP) is excited to announce a series of mini seminars on single-cell techniques, new approaches, and innovations in the field.
Our first seminar will take place on October 31st, and we are delighted to host Takara Bio, who will present their new Shasta Single Cell Solution.
This hybrid event allows you to attend either in person or online. To reserve your spot, please register using this link.
Event details:
- When: Thursday, October 31st, 12:00 PM
- Where: G12, New Hunt's House, KCL, SE1 1UL, London (and online via Teams)
To join the meeting online: (not working)
Meeting ID: 379 778 071 011
Passcode: odALZx
Agenda:
- 12:00 – Welcome! – Dasha Freydina, SCOP
- 12:05 – Shasta: High Throughput Single-Cell RNA-/DNA-Seq – Renata Almeida, Takara Bio
- 12:30 – Q&A – Renata Almeida, Takara Bio
- 12:45 – Wrap-up, followed by pizza 🍕, mochi, and spooky treats 🎃!
We look forward to seeing you there!
------------------------------------------------
21st November 2024
Our second seminar will take place on November 21st, where we are delighted to welcome 10x Genomics, who will present their latest product releases.
This hybrid event allows you to attend either in person or online. To reserve your spot in person, please register using this link.
Event details:
- When: Thursday, November 21st, 11:00 AM
- Where: G12, New Hunt's House, KCL, SE1 1UL, London (and online via Teams)
To join the meeting online: (not working)
Meeting ID: 357 433 002 988
Passcode: LmZKYM
Agenda:
- 11:00 AM - 11:15 AM: Welcome, Dasha Freydina, Single Cell Omics Platform (SCOP) Manager
- 11:15 AM - 12:00 PM: 10x Product Updates, Nicola Cahill, 10x Genomics
- 12:00 PM - 12:40 PM: Technical Considerations, Carla Botas, 10x Genomics
Refreshments and tea/coffee will be served at this event.
----------------------------------------------
2025
20th January 2025
Our third seminar will take place on January 20th 2025, where we are delighted to welcome BD Biosciences, who will present their BD Rhapsody Single cell RNA-seq applications and MultiOmics.
This hybrid event allows you to attend either in person or online. To reserve your spot in person, please register using this link.
Event details:
- When: Monday, 20th January, 12:00 – 13.45
- Where: G12, New Hunt's House, KCL, SE1 1UL, London (and online via Teams)
To join the meeting online: LINK
Meeting ID: 335 733 375 622
Passcode: h7BP7V5m
Agenda:
- 12:00 - 12:30: Light Lunch
- 12:30 - 12:35: Welcome, Dasha Freydina, Single Cell Omics Platform (SCOP) Manager
- 12:35 - 13:15: Accelerate discoveries with single-cell RNAseq and MultiOmics, Hasi Patel, BD
- 12:00 - 12:40: Bioinformatics, Dr Syabira Yusoff, BD
- 13:35 - 13:35: Q&A and Wrap-up
Single-Cell Sequencing
We offer end-to-end single-cell sequencing services, from library preparation to FASTQ data delivery, using multiple cutting-edge platforms:
10x Genomics (Chromium X)
Assays: 3′ Gene Expression, 5′ Gene Expression, V(D)J - TCR/BCR, Multiome ATAC, GEM-X Flex, OCM (on-chip multiplexing)
Application: High-throughput single-cell RNA-seq, immune profiling, and multimodal analysis combining gene expression and chromatin accessibility
BD Rhapsody
Assays: Targeted gene expression, immune profiling panels
Application: Rare cell populations, low-input samples, and targeted gene panels.
Parse Biosciences
Assays: Combinatorial barcoding RNA-seq
Application: Large-scale transcriptomic studies, compatible with fixed or frozen samples.
PIP-Seq (Illumina)
Assays: Plate-based full-length RNA-seq
Application: Detailed transcriptomic analyses, isoform detection, and method development.
ddSEQ (Bio-Rad)
Assays: Single-Cell 3′ RNA-Seq Kit (gene expression) and Single-Cell ATAC-Seq Kit (chromatin accessibility)
Application: Gene expression profiling for small- to medium-scale studies; single-cell ATAC-seq for profiling regulatory landscapes and cell identity.
Consulting and Training
We provide expert consulting on experimental design, platform selection, and assay optimisation for any budget or starting material, offering personalised guidance throughout your single-cell sequencing projects.
We also offer trial runs to assess cell quality and quantity before committing to full experiments, along with training workshops and seminars to equip researchers with the skills needed to perform single-cell omics research effectively.
Open access equipment
Our facility provides open access to state-of-the-art equipment for single-cell research. Induction and training are provided, and we can advise on access, scheduling, and costs. Please contact us for more information.
Collaboration
We welcome collaborations on projects exploring new methods or pipelines. For ‘out-of-catalogue’ requests or custom experiments, please get in touch to discuss your ideas.
Facility staff
Manager
Technician
Affiliated academics
Professor of Immunobiology
Head of the School of Immunology & Microbial Sciences
Reader in RNA Biology and Immunity
Professor of Immune Regulation and Immunotherapy
Our facility offers open access to state-of-the-art equipment for single-cell research. Induction and training provided. Please contact the SCOP facility single-cell-facility@kcl.ac.uk regarding access, training and costing.
Related equipment
10x Chromium X, 10x Genomics
Chromium X offers cost-effective, lower throughput single cell analysis
4200 TapeStation System, Agilent
High-throughput automated electrophoresis, allows fully automated, easy, and reliable analysis of DNA and RNA samples for up to 96 samples per run.
CellDrop FL, DeNovix
Automated Cell Counter
Qubit™ Flex Fluorometer, Invitrogen™
Fast, accurate DNA, RNA, and protein quantification up to eight samples
BD Rhapsody™ HT Xpress System and Scanner
The BD Rhapsody™ HT Xpress System – a microwell-based single-cell platform for targeted gene expression and immune profiling
2025
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
A Lock, EM Drudi, D Freydina, BM Stramer, F Denk… - bioRxiv, 2025 - biorxiv.org
P31 Single-cell RNA sequencing reveals transcriptional changes induced by cell passage in keloid and normal skin derived stromal cells
A Lock-Soper, D Freydina, F Denk… - British Journal of …, 2026 - academic.oup.com
Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids
G Goss, A Torres-Cano, M Pedna, H Wilson, M Simon… - bioRxiv, 2025 - biorxiv.org
Upcoming events
28th May 2025 - Single-Cell Analysis Workshop
The Single Cell Omics Platform is organising a workshop in collaboration with Nygen. If you’re interested, please find below the registration link for the Single-Cell Analysis Workshop, taking place on 28 May 2025, from 10:00 to 12:30.
The workshop is free to attend, but places are limited, so early registration is recommended.
Please note: participants are required to bring their own laptops for the hands-on session.
Please feel free to share this event with your colleagues. If you’re no longer able to attend, kindly let me know.
--------------------------------
The Single Cell Omics Platform (SCOP) is excited to announce a series of mini seminars on single-cell techniques, new approaches, and innovations in the field.
12th June 2025
You are warmly invited to attend an upcoming SCOP seminar focused on Single Cell and Spatial Technologies, bringing together users and industry representatives for a day of knowledge-sharing and discussion.
🗓 Date: 12th June 2025
🕙 Time: 10am - 12.30pm
📍 Location: Guy's New Hunts House, Room G.8 (Ground Floor)
Draft Agenda (TBC):
-
Introduction – SCOP
-
Company Presentations
-
Two short talks (~20 mins each) from 10x Genomics and Cell Signaling Technology (CST)
-
-
Research Presentations
-
Four short talks (10 mins + 5 mins Q&A) from SCOP users, scheduled between the company sessions
-
-
Lunch & Informal Discussion – An opportunity to network and continue the conversation
We’re aiming for a relatively informal format with plenty of opportunity for interaction and engagement throughout the day.
Confirmed Speakers So Far:
-
Onofrio Zanin (Martinez Group): Single Cell Profiling of Airway Samples in Severe Asthma
-
Cara Brown (Hayday Group): Gamma Delta Transcriptomics
-
TBC: GEM-X Flex Assay
-
TBC: On-Chip Multiplexing Assay
We hope you can join us for what promises to be an insightful and collaborative session.
Archive
2023
Established in September 2023, the Single Cell Omics Platform (SCOP) aims to provide state-of-the-art facilities and expert support to researchers interested in single-cell omics analyses. With support from esteemed research groups including the Hayday Group, Taams Lab, Martinez-Nunez group, Inflammation Biology Group, Tree Group, and the School of Immunology & Microbial Science (SIMS), SCOP is dedicated to advancing single-cell research and fostering collaboration within the scientific community.
2024
29th May 2024
I am pleased to invite you to a seminar on "Single Cell Sample Prep and Product Updates" sponsored by 10x Genomics, in collaboration with the Single Cell Omics Platform (SCOP).
Date: Wednesday, 29th May 2024
Time: 9:30 am - 11:10 am
Venue: Room G12 - Ground floor at New Hunt's House (Guy's Campus, SE1 1UL) and Hybrid – MS Teams (Join the meeting now)
AGENDA:
9:30 am - Welcome (5 min) - Dasha Freydina, SCOP
9:35 am - Sample preparation: designing your single-cell experiment (35 min) & Q&A (10 min) - Carla Botas, 10x Genomics
10:15 am - Coffee break (15 min)
10:30 am - Product technical updates (30 min) & Q&A (10 min) - Carla Botas, 10x Genomics
-
GEM-X: New 5' and 3' Single Cell Chemistry
-
Flex assay: technical overview of our Fix assay
-
Single Cell Multiome ATAC and Gene Expression
11:10 am - Wrap up - Dasha Freydina, SCOP
This seminar promises valuable insights into sample preparation techniques for single-cell experiments and updates on the latest products and technologies from 10X Genomics. It's an excellent opportunity to enhance your knowledge and network with others doing single cell work and industry professionals.
Please register using the Link (not working anymore) to secure your place. Should you have any questions or require further information, feel free to reach out.
------------------------
31st October 2024
The Single Cell Omics Platform (SCOP) is excited to announce a series of mini seminars on single-cell techniques, new approaches, and innovations in the field.
Our first seminar will take place on October 31st, and we are delighted to host Takara Bio, who will present their new Shasta Single Cell Solution.
This hybrid event allows you to attend either in person or online. To reserve your spot, please register using this link.
Event details:
- When: Thursday, October 31st, 12:00 PM
- Where: G12, New Hunt's House, KCL, SE1 1UL, London (and online via Teams)
To join the meeting online: (not working)
Meeting ID: 379 778 071 011
Passcode: odALZx
Agenda:
- 12:00 – Welcome! – Dasha Freydina, SCOP
- 12:05 – Shasta: High Throughput Single-Cell RNA-/DNA-Seq – Renata Almeida, Takara Bio
- 12:30 – Q&A – Renata Almeida, Takara Bio
- 12:45 – Wrap-up, followed by pizza 🍕, mochi, and spooky treats 🎃!
We look forward to seeing you there!
------------------------------------------------
21st November 2024
Our second seminar will take place on November 21st, where we are delighted to welcome 10x Genomics, who will present their latest product releases.
This hybrid event allows you to attend either in person or online. To reserve your spot in person, please register using this link.
Event details:
- When: Thursday, November 21st, 11:00 AM
- Where: G12, New Hunt's House, KCL, SE1 1UL, London (and online via Teams)
To join the meeting online: (not working)
Meeting ID: 357 433 002 988
Passcode: LmZKYM
Agenda:
- 11:00 AM - 11:15 AM: Welcome, Dasha Freydina, Single Cell Omics Platform (SCOP) Manager
- 11:15 AM - 12:00 PM: 10x Product Updates, Nicola Cahill, 10x Genomics
- 12:00 PM - 12:40 PM: Technical Considerations, Carla Botas, 10x Genomics
Refreshments and tea/coffee will be served at this event.
----------------------------------------------
2025
20th January 2025
Our third seminar will take place on January 20th 2025, where we are delighted to welcome BD Biosciences, who will present their BD Rhapsody Single cell RNA-seq applications and MultiOmics.
This hybrid event allows you to attend either in person or online. To reserve your spot in person, please register using this link.
Event details:
- When: Monday, 20th January, 12:00 – 13.45
- Where: G12, New Hunt's House, KCL, SE1 1UL, London (and online via Teams)
To join the meeting online: LINK
Meeting ID: 335 733 375 622
Passcode: h7BP7V5m
Agenda:
- 12:00 - 12:30: Light Lunch
- 12:30 - 12:35: Welcome, Dasha Freydina, Single Cell Omics Platform (SCOP) Manager
- 12:35 - 13:15: Accelerate discoveries with single-cell RNAseq and MultiOmics, Hasi Patel, BD
- 12:00 - 12:40: Bioinformatics, Dr Syabira Yusoff, BD
- 13:35 - 13:35: Q&A and Wrap-up
Partners
10x Genomics
BD Biosciences
Contact us:
Lab 1.29A Office 1.32A 1st floor, New Hunt’s House, Great Maze Pond, Guy's Campus, King's College London London, SE1 1UL United Kingdom