Professor Kinya Otsu Academics Supervisors BHF Professor of Cardiology Research subject areas Cardiovascular Contact details kinya.otsu@kcl.ac.uk +44 (0) 20 7848 5128
AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6Chi monocytes in pressure-overloaded hearts p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts Cytokine mRNA degradation in cardiomyocytes restrains sterile inflammation in pressure overloaded hearts Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice Administration of a TLR9 inhibitor attenuates the development and progression of heart failure in mice A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M ROS amplification drives mouse spermatogonial stem cell self-renewal FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice Mitochondria and sterile inflammation in the heart Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis Regnase-1, a ribonuclease, in cardiomyocytes regulates immune responses in the heart: SI:Abstracts ISHR-ES Amsterdam Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy Fibroblast-Specific Genetic Manipulation of p38 MAPK in vivo Reveals its Central Regulatory Role in Fibrosis Inflammation and metabolic cardiomyopathy Loss of functionally redundant p38 isoforms in T cells enhances regulatory T cell induction Sterile Inflammation and Degradation Systems in Heart Failure ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity Autophagy during cardiac remodeling Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Macromolecular Degradation Systems and Cardiovascular Aging Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement from the American Heart Association MTOR hyperactivation by ablation of tuberous sclerosis complex 2 in the mouse heart induces cardiac dysfunction with the increased number of small mitochondria mediated through the down-regulation of autophagy p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress Receptor-mediated mitophagy Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation “Autophagy in the Heart”: Special Issue: Autophagy in the Heart BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32 Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation Degradation systems in heart failure Endogenous Ghrelin Attenuates Pressure Overload-Induced Cardiac Hypertrophy via a Cholinergic Anti-Inflammatory Pathway MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway The role of autophagic degradation in the heart Tissue-Specific Regulation of p38α-Mediated Inflammation in Con A-Induced Acute Liver Damage Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart Sex-Specific Control of Central Nervous System Autoimmunity by p38 Mitogen-Activated Protein Kinase Signaling in Myeloid Cells Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period Translation of hemodynamic stress to sterile inflammation in the heart View all publications
13 September 2023 Discovery of heart cell mechanism holds promise for future heart failure treatments Research into an enzyme involved in necrosis (uncontrolled cell death) has uncovered a new mechanism…