I lead the Grubb lab, where we investigate the many ways in which experience can change the development, form and function of the brain. We focus on the mammalian olfactory system, where experience-dependent plasticity takes weird and wonderful forms, including the generation of entirely new neurons through the process of adult neurogenesis. We believe that by studying natural mechanisms of generation and regeneration in the adult brain we can learn important lessons relevant for cellular replacement strategies in brain repair.

Please see my Research Staff Profile for more detail.

Find out more about my research:

Grubb Lab

CDN - Matthew Grubb

 

Key publications:

• Galliano et al., 2020. Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons. bioRxiv.
• Brann et al., 2020. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. bioRxiv.
• Galiano et al., 2018. Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron. eLife.
• Chand et al., 2015. A Distinct Subtype of Dopaminergic Interneuron Displays Inverted Structural Plasticity at the Axon Initial Segment Articles. Journal of Neuroscience.
• Evans et al., 2015. Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing. Cell Press.

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Key collaborators:

• Professor Eugene Makeyev, King's College London
• Professor Jon Mill, University of Exeter
• Dr Iain Macaulay, Earlham Institute
• Professor Venki Murthy, Harvard University