Parkinson’s and Huntington’s diseases

Our brains change as we age, increasing the risk of neurodegenerative disorders, such as Parkinson’s and Huntington’s diseases. Neurodegenerative disorders are conditions that cause the loss or damage of brain cells and circuits with devastating results. We investigate all aspects of these diseases – from the underlying genetic causes through to how we treat patients in the clinic.

Many think Parkinson’s disease only affects movement, with symptoms such as tremors and rigidity making everyday tasks impossible. Our research also addresses the other, non-motor, symptoms, which may include problems with bladder and bowel control, eating, swallowing and saliva control, sleeping and many other areas, identified as a key area of unmet need by The National Institute for Health and Care Excellence (NICE).

Unlike Parkinson’s disease, with its complex genetic background, Huntington’s is caused by changes in a single gene, which initiates the changes in the brain of this terrible disease. Our research into the way proteins fold in cells, and how any changes can cause clumping, may play a vital role in the development of new drugs to treat neurodegenerative diseases. We work to identify new markers to track disease progression so any future treatments can be given at the earliest opportunity. Whether mapping genes, investigating disease progressions or working with patients in the clinic, we are committed to finding a cure and improving outcomes for people affected.

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