My lab is interested in studying the mechanisms that prevent protein misfolding and accumulation in neurodegenerative diseases, such as molecular chaperones and autophagy. While the relevance of these mechanisms to neurodegeneration has been widely studied in neurons, their importance in glial cells such as astrocytes, has not received as much attention so far. Research in the lab is funded by an MRC Career Development Award to study chaperones as molecular targets to prevent Alzheimer’s disease in the context of astrocyte-neuron communication.

Please see my Research Staff Profile for more detail.

Find out more about my research:

• Jimenez-Sanchez Lab

Key Publications:

• Sung & Jimenez-Sanchez, 2020. Autophagy in astrocytes and its implications in neurodegeneration. Journal of Molecular Biology.
• Jimenez-Sanchez et al., 2015. siRNA screen identifies QPCT as a druggable target for Huntington’s disease. Nature Chemical Biology.
• Jimenez-Sanchez et al., 2012. The Hedgehog signalling pathway regulates autophagy. Nature Communications.

View all publications

Key Collaborators:

• Dr Wendy Noble, King's College London
• Dr Beatriz Gomez Perez-Nievas, King's College London
• Professor Diane Hanger, King's College London