My lab aims to understand basic processes in neuronal function and development by identifying the key pathways and genes involved to provide novel insight into neurological disease.Our work will contribute in the long term to improved quality of life by providing new knowledge about nervous system function and development that can be used to combat neuropathological disease. Our two main areas of interest are:

• Mitochondrial dysfunction in the nervous system and its role in neurodegenerative disease
• Regulation of neurogenesis by mTOR signalling and its role in epilepsy

Please see my Research Staff Profile for more detail.

 

Find out more about my research:

• https://www.kcl.ac.uk/research/bateman-research-group

Key Publications:

• Granat et al., 2023. Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency. PLOS Genetics.
• Baskaran et al., 2022. Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis. Journal of Biological Chemistry. 
• Vinsland et al., 2021. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Scientific Reports. 
• Hunt et al., 2019. Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate. Journal of Cell Biology.
• Gatt et al., 2016. Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency. Movement Disorders.
• Cagin et al., 2015. Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci USA

View all publications

Key Collaborators:

• Dr Sila Ultanir, Francis Crick Institute
• Professor Navdeep Chandel, Northwestern University
• Professor Jernej Murn, University of California Riverside
• Dr Cathy Fernandes, King's College London