Our research focuses around role of lipid mediators in pathomechanisms of chronic inflammatory diseases such as asthma, rhinosinusitis and allergy. Using newly developed molecular and cellular biology methods we characterise functions and signalling of G-protein coupled receptors for eicosanoids (leukotrienes, prostaglandins) and sphingolipids (sphingosine-1-phosphate) and their role in immune response.