An ACQUITY UPLC H-Class PLUS System for separation of analytes in reversed phase chromatography at pressures up to 15,000 psi; a Photodiode Array Detector (PDA) for UV-vis detection over a wavelength range of 190-500 nm; coupled to a Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometer allowing accurate mass measurement, high resolution and sensitivity with a mass range up to m/z 100,000. It features an interchangeable universal ion source architecture, allowing the use of nanoESI and ESI ion sources on the same instrument.