Sami Abdullah Almohefer finished his BDS degree from King Saud University in 2013. Then he worked at Hail University as a teaching assistant for one year. In 2014, he took his internship at Indiana University in the United States. Afterwards, he started his Prosthodontics residency program at Indiana University in the United states in 2015.

In 2018, Sami started his full-time PhD program at King's College London.  His research is focused on the use of different techniques to measure dentine erosive tooth wear under the supervision of Prof. David Bartlett and Dr. Rebecca Moazzez. He is expected to finish by 2021.