My lab builds computational models of brain networks, to understand how brain structure is linked to its dynamics and function. The brain is composed of complex networks of neurons, which underlie its adaptive and versatile functionality. How these neuronal networks communicate with each other and self-organise to give rise to the rich repertoire of neural dynamics observed in the brain is not clear. My lab approaches this problem through data-constrained computational modelling and theoretical analysis of large-scale neuronal networks. By building computational models of neural circuits and analysis of neural activity, we aim to reveal the fundamental mechanisms underlying the operation of the brain in healthy and disease conditions.

Please see my  Research Staff Profile for more details.

Find out more about my research:

• Sadeh Lab
• Crick - Sadra Sadeh

Key Publications:

• Sadeh and Clopath, 2020. Theory of neuronal perturbome in cortical networks. PNAS.
• Sadeh and Clopath, 2021. Inhibitory stabilization and cortical computation. Nat Rev Neurosci.
• Geiler et al., 2022. Local circuit amplification of spatial selectivity in the hippocampus. Nature.
• Radulescu et al., 2023. Age-related dysregulation of homeostatic control in neuronal microcircuits. Nat Neurosci.
• Tomé et al., 2024. Dynamic and selective engrams emerge with memory consolidation. Nat Neurosci.

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Key Collaborators:

• Professor Oscar Marín, King's College London
• Professor Laura Andreae, King's College London
• Dr Florencia Iacaruso, Francis Crick Institute 
• Professor Andreas Schaefer. Francis Crick Institute