Professor Jo Spencer Academics Supervisors Professor of Experimental Medicine Research subject areas Immunology Contact details jo.spencer@kcl.ac.uk +44 (0) 20 7848 9609
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood Weller et al., T-independent responses to polysaccharides in humans mobilize marginal zone B cells pre-diversified against gut bacterial antigens[1] Human B cells Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue Heritable diversity in the human antigen inexperienced B cell repertoire B cells in human lymphoid structures The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-γ production against purified HLA proteins ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants The phenotype of HLA-binding B-cells from sensitised renal transplant recipients correlates with clinically prognostic patterns of IFNγ production against purified HLA proteins Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis Disrupted Peyer’s patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts Human gut-associated lymphoid tissues (GALT); diversity, structure, and function Quantitative assessment of NFκB transcription factor activity Human marginal zone B cell development from early T2 progenitors Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells Sneddon Syndrome associated with two novel ADA2 gene mutations Reduced CD27-IgD- B cells in blood and raised CD27-IgD- B cells in gut-associated lymphoid tissue in inflammatory bowel disease. Human intestinal lymphoid tissue in time and space Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study Can concurrent abnormalities in free light chains and immunoglobulin concentrations identify a target population for immunoglobulin trials in sepsis? Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model The human intestinal B-cell response Mucosal B Cell Differentiation and Regulation Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes Clinical evidence for allergy in orofacial granulomatosis and inflammatory bowel disease Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus IMMUNOGTOBUTLN G CONCENTRATIONS AND OUTCOMES CRITICALLY ILL ADULTS WITH SEPSIS: A SYSTEMATIC REVIEW ES IN CRITICALLY B CELLS WITH BOTH SURFACE KAPPA AND LAMBDA LIGHT CHAINS ARE PRESENT IN THE CIRCULATION IN ICU PATIENTS WITH SEPSIS AND THEIR FREQUENCY CORRELATES WITH FREE LIGHT CHAIN CONCENTRATIONS IN SERUM FREE IMMUNOGLOBULIN LIGHT CHAIN CONCENTRATIONS, RATIOS ANT) OUTCOMES IN CRITICALLY ILL ADULTS WITH SEPSIS: A COHORT STUDY Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis LOW IMMUNOGLOBULIN I; LEVELS AT ADMISSION REDUCES THE ODDS FOR 28 DAY MORTALITY COMPARED TO NORMAL LEVELS: PROSPECTIVE COHORT STUDY IN SEVERE SEPSIS Immunoglobulin kappa variable region gene selection during early B cell development in health and systemic lupus erytyhematosus Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis Defective CD8(+)CD28(-) regulatory T cell suppressor function in rheumatoid arthritis is restored by tumour necrosis factor inhibitor therapy A role for gut-associated lymphoid tissue in shaping the human B cell repertoire Transitional B Cells: How Well Are the Checkpoints for Specificity Understood? Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective The human intestinal IgA response; burning questions Subepithelial dendritic B cells in orofacial granulomatosis Granulomatosis with polyangiitis involves sustained mucosal inflammation that is rich in B-cell survival factors and autoantigen Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjogren's syndrome: clinical implications and effects of B cell-targeted therapies Pivotal Advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans View all publications
17 May 2024 Features of autoimmune diseases found to be normal components of gut immunity Researchers have found that cell types and molecules usually associated with autoimmune disease are…