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Polychronis  Pavlidis

Dr Polychronis Pavlidis

Clinical Lecturer in Gastroenterology

Research interests

  • Immunology

Biography

Polychronis is a clinician-scientist specialising in gastroenterology. His clinical and research focus is on chronic inflammatory gastrointestinal conditions. During his PhD, Polychronis explored the role of interleukin 22 in inflammatory bowel disease and acute gastrointestinal graft versus host disease by utilising human organoids, transcriptomics and flow cytometry. Using the transcriptional modules regulated by canonical cytokines in human intestinal epithelial cells generated through this work he developed a molecular immunophenotyping tool with prognostic value in both ulcerative colitis and Crohn’s disease.

Following on from this work, Polychronis is currently working on elucidating the mechanisms driving nonresponse to available biological therapies in IBD.

Awards:
First Prize for Best Poster, Dr Falk Symposium, Oxford 2019, ‘IBD: From Pathophysiology to personalised medicine’, Scientific Committee: Prof Powrie, Prof Neurath, Prof Kaser Young Investigator Bursary Award for EASL 2019 Abstract of Distinction, BSG Conference 2018 Award for Best IBD poster, BSG Conference 2015 Shire Innovation Fund Award 2013 National Scholar Award, UEG, 2013

Funding:
King’s Medical Research Trust, Rosetrees Trust, For Crohn’s/Core, GutsUK, King’s Challenge Fund, Crohn’s Colitis UK (CCUK)

    News

    Studies reveal complexity of immune responses in patients receiving treatment for Crohn's disease and ulcerative colitis

    The findings provide a better understanding of the interactions between the immune system and epithelium, with potential to inform novel treatments.

    IBD

      News

      Studies reveal complexity of immune responses in patients receiving treatment for Crohn's disease and ulcerative colitis

      The findings provide a better understanding of the interactions between the immune system and epithelium, with potential to inform novel treatments.

      IBD