![Michele Mishto](/newimages/folsm/person-profile/sims/michele-mishto.xfbca87bb.png?f=webp)
Dr Michele Mishto
Reader in Immunobiology
Research interests
- Cancer
- Immunology
Biography
Michele Mishto, Dr. rer. Nat. ORCHID: 0000-0003-3042-2792
Biosketch
October 2021-present Reader in Immunobiology
2017- October 2021 Senior Lecturer and group leader at Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom
2016-2017 Visiting professor at the Department of Health Sciences, Universita' del Piemonte Orientale, Novara, Italy.
2010-2017 Visiting P.I./Research Associate at the Institut für Biochemie - Charité, Berlin, Germany with funds attracted in Italy and U.S as visiting P.I.
2008-2010 Humboldt Stiftung Fellow at the Institut für Biochemie, Charité, Berlin, Germany.
2005-2008 Research Associate at Laboratory of Immunology - University of Bologna, Italy.
2001-2005 PhD fellowship at Laboratory of Immunology - University of Bologna, Italy.
2000-2001 Postgraduate fellowship at Laboratory of Immunology - University of Bologna, Italy.
Research interests
Proteasome is the core of the ubiquitin-proteasome system and responsible of the degradation of the majority of the protein in the cytosol. It is therefore involved in a large variety of metabolic pathways, including inflammation and antigen processing and presentation.
Proteasome produces fragments by canonical peptide-bond hydrolysis or by peptide splicing. Indeed, proteasome can break a protein and reshuffle its sequence by combining non-continuous fragments, thereby generating spliced peptides. By peptide splicing, proteasome significantly enlarges the antigenic landscape of a cell.
We investigate the implications of this mechanism in tumour immunology, autoimmunity and in the CD8+ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.
Furthermore, by applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we study how proteasome isoforms regulate the inflammation in the intracellular and extracellular space by degrading proteins and producing (pro)inflammatory peptides.
Funds
1. CRUK Programme Foundation Award (2020-2026)
2. BRC3-IIa (2019-2022)
3. MPI-BPC Goettingen personal fund (2018-2019)
4. Development fund CRUK-KHP (2018-2019)
5. Monash-KCL Seed fund (2018-2019)
Teaching
Immunology MSc
Molecular Immunology BSc (and module organiser)
Immunology and Immunotherapy of Cancer BSc
Research
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Mishto Lab
The Mishto Lab is led by Dr Michele Mishto, Peter Gorer Department of Immunobiology
![diversity and inclusion hands ch design csi mobil 743x496](/newimages/cicelysaunders/hero-and-carousel-banners/diversity-and-inclusion-hands-ch-design-csi-mobil-743x496.x3b79ee63.jpg?w=780&h=521&crop=780,440,0,22&width=380&height=215&fit=crop&f=webp)
School of Immunology & Microbial Sciences: Development, Diversity & Inclusion
The work of the Development, Diversity & Inclusion committee for the School of Immunology & Microbial Sciences
![Crick](/ImportedImages/Schools/NMS/Crick.x8b693737.jpg?w=780&h=850&crop=780,440,0,205&width=380&height=215&fit=crop&f=webp)
The Francis Crick Institute
King’s is delighted to be a founding academic partner alongside UCL and Imperial College in the Francis Crick Institute, joining the multidisciplinary research expertise from all the Partners together to deliver world-leading biomedical research.
Research
![pipette 1800 x 500 banner.](/newimages/folsm/hero-banner/pipette-1800-x-500-banner..x8d342701.png?w=1584&h=440&crop=780,440,402,0&width=380&height=215&fit=crop&f=webp)
Mishto Lab
The Mishto Lab is led by Dr Michele Mishto, Peter Gorer Department of Immunobiology
![diversity and inclusion hands ch design csi mobil 743x496](/newimages/cicelysaunders/hero-and-carousel-banners/diversity-and-inclusion-hands-ch-design-csi-mobil-743x496.x3b79ee63.jpg?w=780&h=521&crop=780,440,0,22&width=380&height=215&fit=crop&f=webp)
School of Immunology & Microbial Sciences: Development, Diversity & Inclusion
The work of the Development, Diversity & Inclusion committee for the School of Immunology & Microbial Sciences
![Crick](/ImportedImages/Schools/NMS/Crick.x8b693737.jpg?w=780&h=850&crop=780,440,0,205&width=380&height=215&fit=crop&f=webp)
The Francis Crick Institute
King’s is delighted to be a founding academic partner alongside UCL and Imperial College in the Francis Crick Institute, joining the multidisciplinary research expertise from all the Partners together to deliver world-leading biomedical research.