Dr Manuel Müller is a Reader in Chemical Biology in the Department of Chemistry, King’s College London. He studied biochemistry and chemistry at ETH Zurich. After a summer internship with Prof. Andrew Ellington at UT Austin in 2006, Müller returned to ETH where he completed his PhD in protein engineering and evolution under the supervision of Prof. Donald Hilvert in 2010. For his postdoctoral work, he joined Prof. Tom Muir’s lab in Princeton where he developed and applied chemical biology tools to study chromatin modifying enzymes. In 2016, Manuel was awarded a Sir Henry Dale Fellowship of the Wellcome Trust and the Royal Society to launch his independent group at King’s College London. He was awarded the RSC Norman Heatley Award (2021) and was promoted to Reader in 2022. 

Research Interests

• Post-translational modifications
• Synthetic protein chemistry
• Solid-phase peptide synthesis
• p53

Research in the Müller lab focuses on developing and applying chemical biology tools to elucidate how proteins are controlled by post-translational modifications. The Müller lab is particularly interested in modifications of the polypeptide backbone, and how such processes are involved in molecular ageing. Moreover, the lab has developed the semisynthesis of site-specifically phosphorylated p53 and apoptin, allowing us to investigate how these anticancer proteins are controlled by post-translational modifications.

Teaching

• Molecular Biology (3^rd Year Module)
• Frontiers in Chemistry (MSci Module)
• Core skills for interdisciplinary chemistry MRes

Research Centres or Groups

• Associate Member of the Crick Structural and Chemical Biology Interest Group

More Information

• Mueller Lab