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Manuel Müller

Dr Manuel Müller

Reader in Chemical Biology

Research interests

  • Chemistry

Biography

Dr Manuel Müller is a Reader in Chemical Biology in the Department of Chemistry, King’s College London. He studied biochemistry and chemistry at ETH Zurich. After a summer internship with Prof. Andrew Ellington at UT Austin in 2006, Müller returned to ETH where he completed his PhD in protein engineering and evolution under the supervision of Prof. Donald Hilvert in 2010. For his postdoctoral work, he joined Prof. Tom Muir’s lab in Princeton where he developed and applied chemical biology tools to study chromatin modifying enzymes. In 2016, Manuel was awarded a Sir Henry Dale Fellowship of the Wellcome Trust and the Royal Society to launch his independent group at King’s College London. He was awarded the RSC Norman Heatley Award (2021) and was promoted to Reader in 2022. 

Research Interests

  • Post-translational modifications
  • Synthetic protein chemistry
  • Solid-phase peptide synthesis
  • p53

Research in the Müller lab focuses on developing and applying chemical biology tools to elucidate how proteins are controlled by post-translational modifications. The Müller lab is particularly interested in modifications of the polypeptide backbone, and how such processes are involved in molecular ageing. Moreover, the lab has developed the semisynthesis of site-specifically phosphorylated p53 and apoptin, allowing us to investigate how these anticancer proteins are controlled by post-translational modifications.

Teaching

  • Molecular Biology (3rd Year Module)
  • Frontiers in Chemistry (MSci Module)
  • Core skills for interdisciplinary chemistry MRes

Research Centres or Groups

  • Associate Member of the Crick Structural and Chemical Biology Interest Group

More Information

    Research

    Overview
    Müller Group

    Research in the Müller lab focuses on using synthetic protein chemistry to elucidate how proteins are controlled by post-translational modifications.

    News

    NMES academic promotions

    New readers and senior lecturers in NMES

    Congratulations

    King's Chemist wins Royal Society of Chemistry 2021 Norman Heatley Award

    Dr Manuel Müller has received the award in recognition for his contributions to the field of posttranslational modifications, particularly in the use of...

    Dr Manuel Müller

    Events

    20FebPSoL Inaugural Symposium

    Centre for the Physical Science of Life Inaugural Symposium

    Please join us in-person for the Centre for the Physical Science of Life Inaugural Symposium at King’s College London.

    Please note: this event has passed.

      Research

      Overview
      Müller Group

      Research in the Müller lab focuses on using synthetic protein chemistry to elucidate how proteins are controlled by post-translational modifications.

      News

      NMES academic promotions

      New readers and senior lecturers in NMES

      Congratulations

      King's Chemist wins Royal Society of Chemistry 2021 Norman Heatley Award

      Dr Manuel Müller has received the award in recognition for his contributions to the field of posttranslational modifications, particularly in the use of...

      Dr Manuel Müller

      Events

      20FebPSoL Inaugural Symposium

      Centre for the Physical Science of Life Inaugural Symposium

      Please join us in-person for the Centre for the Physical Science of Life Inaugural Symposium at King’s College London.

      Please note: this event has passed.