
Professor Kypros Nicolaides
Professor of Fetal Medicine
- Founder and chairman of the of The Fetal Medicine Foundation
Contact details
Biography
Professor Kypros Nicolaides is the founder and chairman of the of The Fetal Medicine Foundation (FMF) which he set up in 1995. The FMF has donated more than £45 million to finance the training of doctors from around the world and to carry out major multi-centre research studies in fetal medicine. The Fetal Medicine Foundation also organises the yearly World congress in Fetal Medicine which is attended by more than 2000 participants from all over the world.
Professor Nicolaides has authored over 1500 peer-reviewed journal articles and more than 30 books. He has an H-index of 183, which is the highest of any Obstetrician & Gynaecologist in the world, and has had his research cited over 135,000 times. He has provided training in Fetal Medicine to over 1000 doctors from over 50 countries.Professor Kypros Nicolaides has developed methods of (i) screening for premature birth (which is the main cause of perinatal morbidity and mortality) by measurement of cervical length and prevention through the use of vaginal progesterone (ii) screening for pre-eclampsia (which is one of the main causes of maternal mortality) by measurement of blood flow to the uterus by Doppler and measurement of blood pressure and the hormone placental growth factor and prevention through the use of aspirin (iii) methods of early screening for chromosomal abnormalities through the measurement of nuchal translucency, and spina bifida through the ‘lemon and banana’ signs, and (iv) methods of fetal therapy including fetal blood transfusions for red cell isoimmunized pregnancies, thoraco-amniotic shunting for fetal pleural effusions, endoscopic laser surgery for identical twin pregnancies with severe twin-to-twin transfusion syndrome in collaboration with Professor Yves Ville and endoscopic placement of a balloon in the fetal trachea for the treatment of severe diaphragmatic hernia in collaboration with Professors Jan Deprest and Eduard Gratacos.
He has recently proposed a new model of pregnancy care – “Turning the Pyramid of Prenatal Care”. This aims to assess the risk for most of the relevant pregnancy complications affecting mother and unborn child during a hospital visit at 11-13 weeks of gestation and, on the basis of such risks, provide personalised care to reduce an adverse outcome.
Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia
El Hoss, S., Shangaris, P., Brewin, J., Psychogyiou, M. E., Ng, C., Pedler, L., Rooks, H., Gotardo, É. M. F., Gushiken, L. F. S., Brito, P. L., Nicolaides, K. H., Conran, N., Rees, D. C. & Strouboulis, J., 5 Dec 2024, (E-pub ahead of print) In: Haematologica.Research output: Contribution to journal › Article › peer-review
The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes
Mureanu, N., Bowman, A. M., Porter-Wright, I. A., Verma, P., Efthymiou, A., Nicolaides, K. H., Scotta, C., Lombardi, G., Tribe, R. M. & Shangaris, P., 5 Nov 2024, In: International Journal of Molecular Sciences. 25, 22, 11878.Research output: Contribution to journal › Review article › peer-review
Blood pressure cutoffs at 11–13 weeks of gestation and risk of preeclampsia
Slade, L. J., Syngelaki, A., Wilson, M., Mistry, H. D., Akolekar, R., von Dadelszen, P., Nicolaides, K. H. & Magee, L. A., 2024, (Accepted/In press) In: American Journal of Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review
Headen, K., Jakaite, V., Mesaric, V. A., Scotta, C., Lombardi, G., Nicolaides, K. H. & Shangaris, P., 30 Apr 2024, In: International Journal of Molecular Sciences. 25, 9, 4884.Research output: Contribution to journal › Review article › peer-review
Perinatal and neurodevelopmental outcomes of fetal isolated ventriculomegaly: a systematic review and meta-analysis
Ali, F., Gurung, F., Nanda, S., Bakalis, S., Sankaran, S., Arichi, T., Nicolaides, K. H. & Shangaris, P., 30 Apr 2024, In: Translational Pediatrics. 13, 4, p. 555-574 20 p.Research output: Contribution to journal › Article › peer-review
Revolutionising healing: Gene Editing's breakthrough against sickle cell disease
Dimitrievska, M., Bansal, D., Vitale, M., Strouboulis, J., Miccio, A., Nicolaides, K. H., El Hoss, S., Shangaris, P. & Jacków-Malinowska, J., May 2024, In: Blood Reviews. 65, p. 101185 101185.Research output: Contribution to journal › Review article › peer-review
Vascular phenotype at 35–37 weeks’ gestation in women with gestational diabetes mellitus
Mansukhani, T., Arechvo, A., Cecchini, F., Breim, M., Wright, A., Nicolaides, K. H. & Charakida, M., 29 Sept 2022, (E-pub ahead of print) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Effect of race on the measurement of angiogenic factors for prediction and diagnosis of pre-eclampsia
Wright, A., von Dadelszen, P., Magee, L. A., Syngelaki, A., Akolekar, R., Wright, D. & Nicolaides, K. H., 27 Sept 2022, (E-pub ahead of print) In: BJOG.Research output: Contribution to journal › Article › peer-review
Fetoscopic endoluminal tracheal occlusion (FETO) and bilateral congenital diaphragmatic hernia: FETO and bilateral congenital diaphragmatic hernia
Khawash, A., Kronfli, R., Arasu, A., Gandhi, R., Nicolaides, K. & Greenough, A., 2023, In: Case Reports in Perinatal Medicine.Research output: Contribution to journal › Article › peer-review
Incidence of pre‐eclampsia: effect of deprivation
Arechvo, A., Wright, A., Syngelaki, A., von Dadelszen, P., Magee, L. A., Akolekar, R., Wright, D. & Nicolaides, K. H., Jan 2023, In: Ultrasound in Obstetrics and Gynecology. 61, 1, p. 26-32 7 p.Research output: Contribution to journal › Article › peer-review
Suspected twin anemia polycythemia sequence in a dichorionic, diamniotic twin pregnancy: a case report
Jeyaseelan, T., Shangaris, P., Efthymiou, A., Martin, L., Story, L., Nanda, S., Gupta, N., Al-Adnani, M., Marnerides, A., Nicolaides, K. H. & Sankaran, S., Dec 2023, In: Journal of medical case reports. 17, 1, 4 p., 28.Research output: Contribution to journal › Article › peer-review
Prediction of survival in infants with congenital diaphragmatic hernia and the response to inhaled nitric oxide
Arattu Thodika, F., Dimitrova, S., Nanjundappa, M., Davenport, M., Nicolaides, K., Dassios, T. & Greenough, A., Oct 2022, In: European Journal of Pediatrics. 181, 10, p. 3683-3689 7 p.Research output: Contribution to journal › Article › peer-review
Competing-risks model for pre-eclampsia and adverse pregnancy outcomes
Syngelaki, A., Magee, L. A., von Dadelszen, P., Akolekar, R., Wright, A., Wright, D. & Nicolaides, K. H., 1 Sept 2022, In: Ultrasound in Obstetrics and Gynecology. 60, 3, p. 367-372 6 p.Research output: Contribution to journal › Article › peer-review
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
NIHR BioResource & Genomics England Research Consortium Collaborators, Dec 2022, In: Nature Communications. 13, 1, 4840.Research output: Contribution to journal › Article › peer-review
Midgestation cardiovascular phenotype in women who develop gestational diabetes and hypertensive disorders of pregnancy: comparative study
Anzoategui, S., Gibbone, E., Wright, A., Nicolaides, K. H. & Charakida, M., 1 Aug 2022, In: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 60, 2, p. 207-214 8 p.Research output: Contribution to journal › Article › peer-review
Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
Bliddal, S., Derakhshan, A., Xiao, Y., Chen, L. M., Männistö, T., Ashoor, G., Tao, F., Brown, S. J., Vafeiadi, M., Itoh, S., Grineva, E. N., Taylor, P., Ghafoor, F., Vaidya, B., Hattersley, A., Mosso, L., Oken, E., Kishi, R., Alexander, E. K. & Maraka, S. & 20 others, Huang, K., Chaker, L., Bassols, J., Pirzada, A., López-Bermejo, A., Boucai, L., Peeters, R. P., Pearce, E. N., Nelson, S. M. G., Chatzi, L., Vrijkotte, T. G., Popova, P. V., Walsh, J. P., Nicolaides, K. H., Suvanto, E., Lu, X., Pop, V. J. M., Forman, J. L., Korevaar, T. I. M. & Feldt-Rasmussen, U., 1 Jul 2022, In: Thyroid. 32, 7, p. 828-840 13 p.Research output: Contribution to journal › Article › peer-review
Chronic histiocytic intervillositis (CHI): current treatments and perinatal outcomes, a systematic review and a meta-analysis
Moar, L., Simela, C., Nanda, S., Marnerides, A., Al-Adnani, M., Nelson-Piercy, C., Nicolaides, K. H. & Shangaris, P., 22 Jul 2022, In: Frontiers in Endocrinology . 13, p. 1-17 17 p., 945543.Research output: Contribution to journal › Article › peer-review
Maternal Race and Stillbirth: Cohort Study and Systematic Review with Meta-Analysis
Arechvo, A., Nikolaidi, D. A., Gil, M. M., Rolle, V., Syngelaki, A., Akolekar, R. & Nicolaides, K. H., 1 Jun 2022, In: Journal of Clinical Medicine. 11, 12, 3452.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler at 19–23 weeks' gestation in pregnancies that deliver small-for-gestational-age neonates
Abdel Azim, S., Wright, A., Sapantzoglou, I., Nicolaides, K. H. & Charakida, M., Jul 2022, In: Ultrasound in Obstetrics and Gynecology. 60, 1, p. 52-58 7 p.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler at 11–13 weeks' gestation in prediction of pre-eclampsia
Gana, N., Sarno, M., Vieira, N., Wright, A., Charakida, M. & Nicolaides, K. H., Jun 2022, In: Ultrasound in Obstetrics and Gynecology. 59, 6, p. 731-736 6 p.Research output: Contribution to journal › Article › peer-review
Preeclampsia
Magee, L. A., Nicolaides, K. H. & Von Dadelszen, P., 12 May 2022, In: New England Journal of Medicine. 386, 19, p. 1817-1832 16 p., 386.Research output: Contribution to journal › Review article › peer-review
Using ultrasound and angiogenic markers from a 19- to 23-week assessment to inform the subsequent diagnosis of preeclampsia
Lai, J., Syngelaki, A., Nicolaides, K. H., von Dadelszen, P. & Magee, L. A., Aug 2022, In: American Journal of Obstetrics and Gynecology. 227, 2, p. 294.e1-294.e11Research output: Contribution to journal › Article › peer-review
Maternal cardiac function in twin pregnancy at 19–23 weeks' gestation
Nunez, E., Huluta, I., Gallardo Arozena, M., Wright, A., Nicolaides, K. H. & Charakida, M., May 2022, In: Ultrasound in Obstetrics and Gynecology. 59, 5, p. 627-632 6 p.Research output: Contribution to journal › Article › peer-review
Ventilation-to-perfusion relationships and right-to-left shunt during neonatal intensive care in infants with congenital diaphragmatic hernia
Dassios, T., Shareef Arattu Thodika, F. M., Williams, E., Davenport, M., Nicolaides, K. H. & Greenough, A., Dec 2022, In: Pediatric Research. 92, 6, p. 1657-1662 6 p.Research output: Contribution to journal › Article › peer-review
Isolation and freezing of human peripheral blood mononuclear cells from pregnant patients
Efthymiou, A., Mureanu, N., Pemberton, R., Tai-macarthur, S., Mastronicola, D., Scottà, C., Lombardi, G., Nicolaides, K. H. & Shangaris, P., 18 Mar 2022, In: STAR Protocols. 3, 1, 101204.Research output: Contribution to journal › Article › peer-review
Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus
Fan, H. M., Mitchell, A. L., Bellafante, E., McIlvride, S., Primicheru, L. I., Giorgi, M., Eberini, I., Syngelaki, A., Lövgren-Sandblom, A., Jones, P., McCance, D., Sukumar, N., Periyathambi, N., Weldeselassie, Y., Hunt, K. F., Nicolaides, K. H., Andersson, D., Bevan, S., Seed, P. T. & Bewick, G. A. & 5 others, Bowe, J. E., Fraternali, F., Saravanan, P., Marschall, H. & Williamson, C., 1 Apr 2022, In: Diabetes. 71, 4, p. 837-852 16 p.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler at 35-37 weeks' gestation in pregnancies with small or growth-restricted fetuses
Abdel Azim, S., Sarno, M., Wright, A., Vieira, N., Charakida, M. & Nicolaides, K. H., Apr 2022, In: Ultrasound in Obstetrics and Gynecology. 59, 4, p. 483-489 7 p.Research output: Contribution to journal › Article › peer-review
Maternal Cardiac Function at Midgestation and Development of Preeclampsia
Gibbone, E., Huluta, I., Wright, A., Nicolaides, K. H. & Charakida, M., 4 Jan 2022, In: Journal of the American College of Cardiology. 79, 1, p. 52-62 11 p.Research output: Contribution to journal › Article › peer-review
Regulatory T Cells in Pregnancy Adverse Outcomes: A Systematic Review and Meta-Analysis
Green, S., Politis, M., Rallis, K. S., Saenz de Villaverde Cortabarria, A., Efthymiou, A., Mureanu, N., Dalrymple, K. V., Scottà, C., Lombardi, G., Tribe, R. M., Nicolaides, K. H. & Shangaris, P., 29 Oct 2021, In: Frontiers in Immunology. 12, 1 p., 737862.Research output: Contribution to journal › Article › peer-review
Preliminary experience with endoscopic laser surgery for severe twin-twin transfusion syndrome
Ville, Y., Hyett, J., Hecher, K. & Nicolaides, K., 26 Jan 1995, In: New England Journal of Medicine. 332, 4, p. 224-227 4 p.Research output: Contribution to journal › Article › peer-review
Regulatory T Cells in Pregnancy adverse Outcomes (Rutepo): A Systematic Review & Meta-Analysis
Green, S., Politis, M., Rallis, K., Saenz de Villaverde CORTABARRIA, A., Efthymiou , A., Mureanu, N., Dalrymple, K., Scotta, C., Lombardi, G., Tribe, R., Nicolaides, K. & Shangaris, P., 29 Oct 2021, In: Frontiers in immunology. 12, 737862.Research output: Contribution to journal › Article › peer-review
First trimester angiogenic and inflammatory factors in women with chronic hypertension and impact of blood pressure control: a case–control study
Nzelu, D., Nicolaides, K. H. & Kametas, N. A., Dec 2021, In: BJOG: An International Journal of Obstetrics and Gynaecology. 128, 13, p. 2171-2179 9 p.Research output: Contribution to journal › Article › peer-review
A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre-eclampsia: Compiled by the Pregnancy and Non-Communicable Diseases Committee of FIGO (the International Federation of Gynecology and Obstetrics)
Poon, L. C., Magee, L. A., Verlohren, S., Shennan, A., von Dadelszen, P., Sheiner, E., Hadar, E., Visser, G., Da Silva Costa, F., Kapur, A., McAuliffe, F., Nazareth, A., Tahlak, M., Kihara, A. B., Divakar, H., McIntyre, H. D., Berghella, V., Yang, H., Romero, R. & Nicolaides, K. H. & 2 others, Melamed, N. & Hod, M., Jul 2021, In: International Journal of Gynecology and Obstetrics. 154, S1, p. 3-31 29 p.Research output: Contribution to journal › Article › peer-review
Three-dimensional echocardiography and cardiac strain imaging in women with gestational diabetes mellitus
Company Calabuig, A. M., Nunez, E., Sánchez, A., Nicolaides, K. H., Charakida, M. & De Paco Matallana, C., Aug 2021, In: Ultrasound in Obstetrics and Gynecology. 58, 2, p. 278-284 7 p.Research output: Contribution to journal › Article › peer-review
Maternal cardiac function at 19–23 weeks' gestation in prediction of gestational diabetes mellitus
Gibbone, E., Wright, A., Vallenas Campos, R., Anzoategui, S., Nicolaides, K. H. & Charakida, M., Jun 2021, (E-pub ahead of print) In: Ultrasound in Obstetrics and Gynecology. 58, 1, 6 p.Research output: Contribution to journal › Article › peer-review
Reference Ranges for Pulsed-Wave Doppler of the Fetal Cardiac Inflow and Outflow Tracts from 13 to 36 Weeks’ Gestation
Zidere, V., Vigneswaran, T. V., Syngelaki, A., Charakida, M., Allan, L. D., Nicolaides, K. H., Simpson, J. M. & Akolekar, R., Sept 2021, In: Journal of The American Society of Echocardiography. 34, 9, p. 1007-1016.e10Research output: Contribution to journal › Article › peer-review
Relationship between ophthalmic artery Doppler and maternal cardiovascular function
Gibbone, E., Sapantzoglou, I., Nuñez-Cerrato, M. E., Wright, A., Nicolaides, K. H. & Charakida, M., May 2021, In: Ultrasound in Obstetrics and Gynecology. 57, 5, p. 733-738 6 p.Research output: Contribution to journal › Article › peer-review
Maternal cardiac function at 19–23 weeks' gestation in prediction of pre-eclampsia
Gibbone, E., Wright, A., Vallenas Campos, R., Sanchez Sierra, A., Nicolaides, K. H. & Charakida, M., May 2021, In: Ultrasound in Obstetrics and Gynecology. 57, 5, p. 739-747 9 p.Research output: Contribution to journal › Article › peer-review
Impact of gestational diabetes mellitus on fetal cardiac morphology and function: cohort comparison of second- and third-trimester fetuses
Yovera, L., Zaharia, M., Jachymski, T., Velicu-Scraba, O., Coronel, C., de Paco Matallana, C., Georgiopoulos, G., Nicolaides, K. H. & Charakida, M., 2020, (Accepted/In press) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Fetal cardiac function at 35–37 weeks' gestation in pregnancies that subsequently develop pre-eclampsia
Semmler, J., Garcia-Gonzalez, C., Sanchez Sierra, A., Gallardo Arozena, M., Nicolaides, K. H. & Charakida, M., 2020, (Accepted/In press) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Influence of birth weight on fetal cardiac indices at 35–37 weeks' gestation
Semmler, J., Abdel-Azim, S., Anzoategui, S., Zhang, H., Nicolaides, K. H. & Charakida, M., 2020, (Accepted/In press) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Early Detection of Preeclampsia Using Circulating Small non-coding RNA
Yoffe, L., Gilam, A., Yaron, O., Polsky, A., Farberov, L., Syngelaki, A., Nicolaides, K., Hod, M. & Shomron, N., 1 Dec 2018, In: Scientific Reports. 8, 1, 3401.Research output: Contribution to journal › Article › peer-review
Aspirin delays the development of preeclampsia
Wright, D. & Nicolaides, K. H., Jun 2019, In: American Journal of Obstetrics and Gynecology. 220, 6, p. 580.e1-580.e6Research output: Contribution to journal › Article › peer-review
First trimester serum angiogenic and anti-angiogenic factors in women with chronic hypertension for the prediction of preeclampsia
Nzelu, D., Biris, D., Karampitsakos, T., Nicolaides, K. K. & Kametas, N. A., Apr 2020, In: American Journal of Obstetrics and Gynecology. 222, 4, p. 374.e1-374.e9Research output: Contribution to journal › Article › peer-review
The competing risk approach for prediction of preeclampsia
Wright, D., Wright, A. & Nicolaides, K. H., Jul 2020, In: American Journal of Obstetrics and Gynecology. 223, 1, p. 12-23.e7Research output: Contribution to journal › Review article › peer-review
First trimester inflammatory mediators in women with chronic hypertension
Nzelu, D., Dumitrascu-Biris, D., Karampitsakos, T., Nicolaides, K. K. & Kametas, N. A., 1 Sept 2020, In: Acta Obstetricia et Gynecologica Scandinavica. 99, 9, p. 1198-1205 8 p.Research output: Contribution to journal › Article › peer-review
Clinical validation of bioreactance for the measurement of cardiac output in pregnancy
Ling, H. Z., Gallardo-Arozena, M., Company-Calabuig, A. M., Nicolaides, K. H. & Kametas, N. A., 1 Oct 2020, In: Anaesthesia. 75, 10, p. 1307-1313 7 p.Research output: Contribution to journal › Article › peer-review
Impact of new definitions of preeclampsia at term on identification of adverse maternal and perinatal outcomes
Lai, J., Syngelaki, A., Nicolaides, K. H., von Dadelszen, P. & Magee, L. A., 2020, (Accepted/In press) In: American Journal of Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler in prediction of pre-eclampsia at 35–37 weeks' gestation
Sarno, M., Wright, A., Vieira, N., Sapantzoglou, I., Charakida, M. & Nicolaides, K. H., 1 Nov 2020, In: Ultrasound in Obstetrics and Gynecology. 56, 5, p. 717-724 8 p.Research output: Contribution to journal › Article › peer-review
The value of three-dimensional ultrasound in identifying Mullerian anomalies at risk of adverse pregnancy outcomes
Negm, S. M., Kamel, R. A., El-Zayat, H. A., Elbigawy, A. F., El-Toukhy, M. M., Amin, A. H. & Nicolaides, K. H., 1 Jan 2020, (Accepted/In press) In: Journal of Maternal-Fetal and Neonatal Medicine.Research output: Contribution to journal › Article › peer-review
Research

Prenatal ThERapy for SIckle CelL disEaSe (PERICLES)
To generate new knowledge about stakeholders' views on prenatal therapy for Sickle Cell Disease, identify ethical issues and establish protocols for support.
Project status: Ongoing

Regulatory T Cells in Pregnancy Adverse Outcomes (Rutepo)
Tregs play a critical role in maintaining immune tolerance during pregnancy, and their dysfunction has been associated with pregnancy complications.
Project status: Ongoing

Maternal Hypertension
The Hypertension group strategy focuses on improving outcomes for women with hypertension in pregnancy

Vlachodimitropoulou Group
Vlachodimitropoulou Group - our lab stands at the forefront of maternal and fetal health. With a specialized focus on fetal therapy and maternal and fetal hematology.
News
King's researchers evaluate effectiveness of placental growth factor measurement in mid-pregnancy
Among pregnancies with clinical risk factors for pre-eclampsia or fetal growth restriction, PlGF in mid-pregnancy is unhelpful in identifying women and babies...

Scheduled childbirth could cut pre-eclampsia risk by 50%
Latest analysis of data shows that delivering babies earlier at term minimises occurrence of pre-eclampsia in women at increased risk of this important...

Events

Fifth Annual Niki Marangou Memorial Lecture: 'Life before Birth'
Join us for the fifth Niki Marangou Annual Memorial Lecture: Professor Kypros Nicolaides
Please note: this event has passed.
Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia
El Hoss, S., Shangaris, P., Brewin, J., Psychogyiou, M. E., Ng, C., Pedler, L., Rooks, H., Gotardo, É. M. F., Gushiken, L. F. S., Brito, P. L., Nicolaides, K. H., Conran, N., Rees, D. C. & Strouboulis, J., 5 Dec 2024, (E-pub ahead of print) In: Haematologica.Research output: Contribution to journal › Article › peer-review
The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes
Mureanu, N., Bowman, A. M., Porter-Wright, I. A., Verma, P., Efthymiou, A., Nicolaides, K. H., Scotta, C., Lombardi, G., Tribe, R. M. & Shangaris, P., 5 Nov 2024, In: International Journal of Molecular Sciences. 25, 22, 11878.Research output: Contribution to journal › Review article › peer-review
Blood pressure cutoffs at 11–13 weeks of gestation and risk of preeclampsia
Slade, L. J., Syngelaki, A., Wilson, M., Mistry, H. D., Akolekar, R., von Dadelszen, P., Nicolaides, K. H. & Magee, L. A., 2024, (Accepted/In press) In: American Journal of Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review
Headen, K., Jakaite, V., Mesaric, V. A., Scotta, C., Lombardi, G., Nicolaides, K. H. & Shangaris, P., 30 Apr 2024, In: International Journal of Molecular Sciences. 25, 9, 4884.Research output: Contribution to journal › Review article › peer-review
Perinatal and neurodevelopmental outcomes of fetal isolated ventriculomegaly: a systematic review and meta-analysis
Ali, F., Gurung, F., Nanda, S., Bakalis, S., Sankaran, S., Arichi, T., Nicolaides, K. H. & Shangaris, P., 30 Apr 2024, In: Translational Pediatrics. 13, 4, p. 555-574 20 p.Research output: Contribution to journal › Article › peer-review
Revolutionising healing: Gene Editing's breakthrough against sickle cell disease
Dimitrievska, M., Bansal, D., Vitale, M., Strouboulis, J., Miccio, A., Nicolaides, K. H., El Hoss, S., Shangaris, P. & Jacków-Malinowska, J., May 2024, In: Blood Reviews. 65, p. 101185 101185.Research output: Contribution to journal › Review article › peer-review
Vascular phenotype at 35–37 weeks’ gestation in women with gestational diabetes mellitus
Mansukhani, T., Arechvo, A., Cecchini, F., Breim, M., Wright, A., Nicolaides, K. H. & Charakida, M., 29 Sept 2022, (E-pub ahead of print) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Effect of race on the measurement of angiogenic factors for prediction and diagnosis of pre-eclampsia
Wright, A., von Dadelszen, P., Magee, L. A., Syngelaki, A., Akolekar, R., Wright, D. & Nicolaides, K. H., 27 Sept 2022, (E-pub ahead of print) In: BJOG.Research output: Contribution to journal › Article › peer-review
Fetoscopic endoluminal tracheal occlusion (FETO) and bilateral congenital diaphragmatic hernia: FETO and bilateral congenital diaphragmatic hernia
Khawash, A., Kronfli, R., Arasu, A., Gandhi, R., Nicolaides, K. & Greenough, A., 2023, In: Case Reports in Perinatal Medicine.Research output: Contribution to journal › Article › peer-review
Incidence of pre‐eclampsia: effect of deprivation
Arechvo, A., Wright, A., Syngelaki, A., von Dadelszen, P., Magee, L. A., Akolekar, R., Wright, D. & Nicolaides, K. H., Jan 2023, In: Ultrasound in Obstetrics and Gynecology. 61, 1, p. 26-32 7 p.Research output: Contribution to journal › Article › peer-review
Suspected twin anemia polycythemia sequence in a dichorionic, diamniotic twin pregnancy: a case report
Jeyaseelan, T., Shangaris, P., Efthymiou, A., Martin, L., Story, L., Nanda, S., Gupta, N., Al-Adnani, M., Marnerides, A., Nicolaides, K. H. & Sankaran, S., Dec 2023, In: Journal of medical case reports. 17, 1, 4 p., 28.Research output: Contribution to journal › Article › peer-review
Prediction of survival in infants with congenital diaphragmatic hernia and the response to inhaled nitric oxide
Arattu Thodika, F., Dimitrova, S., Nanjundappa, M., Davenport, M., Nicolaides, K., Dassios, T. & Greenough, A., Oct 2022, In: European Journal of Pediatrics. 181, 10, p. 3683-3689 7 p.Research output: Contribution to journal › Article › peer-review
Competing-risks model for pre-eclampsia and adverse pregnancy outcomes
Syngelaki, A., Magee, L. A., von Dadelszen, P., Akolekar, R., Wright, A., Wright, D. & Nicolaides, K. H., 1 Sept 2022, In: Ultrasound in Obstetrics and Gynecology. 60, 3, p. 367-372 6 p.Research output: Contribution to journal › Article › peer-review
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
NIHR BioResource & Genomics England Research Consortium Collaborators, Dec 2022, In: Nature Communications. 13, 1, 4840.Research output: Contribution to journal › Article › peer-review
Midgestation cardiovascular phenotype in women who develop gestational diabetes and hypertensive disorders of pregnancy: comparative study
Anzoategui, S., Gibbone, E., Wright, A., Nicolaides, K. H. & Charakida, M., 1 Aug 2022, In: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 60, 2, p. 207-214 8 p.Research output: Contribution to journal › Article › peer-review
Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
Bliddal, S., Derakhshan, A., Xiao, Y., Chen, L. M., Männistö, T., Ashoor, G., Tao, F., Brown, S. J., Vafeiadi, M., Itoh, S., Grineva, E. N., Taylor, P., Ghafoor, F., Vaidya, B., Hattersley, A., Mosso, L., Oken, E., Kishi, R., Alexander, E. K. & Maraka, S. & 20 others, Huang, K., Chaker, L., Bassols, J., Pirzada, A., López-Bermejo, A., Boucai, L., Peeters, R. P., Pearce, E. N., Nelson, S. M. G., Chatzi, L., Vrijkotte, T. G., Popova, P. V., Walsh, J. P., Nicolaides, K. H., Suvanto, E., Lu, X., Pop, V. J. M., Forman, J. L., Korevaar, T. I. M. & Feldt-Rasmussen, U., 1 Jul 2022, In: Thyroid. 32, 7, p. 828-840 13 p.Research output: Contribution to journal › Article › peer-review
Chronic histiocytic intervillositis (CHI): current treatments and perinatal outcomes, a systematic review and a meta-analysis
Moar, L., Simela, C., Nanda, S., Marnerides, A., Al-Adnani, M., Nelson-Piercy, C., Nicolaides, K. H. & Shangaris, P., 22 Jul 2022, In: Frontiers in Endocrinology . 13, p. 1-17 17 p., 945543.Research output: Contribution to journal › Article › peer-review
Maternal Race and Stillbirth: Cohort Study and Systematic Review with Meta-Analysis
Arechvo, A., Nikolaidi, D. A., Gil, M. M., Rolle, V., Syngelaki, A., Akolekar, R. & Nicolaides, K. H., 1 Jun 2022, In: Journal of Clinical Medicine. 11, 12, 3452.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler at 19–23 weeks' gestation in pregnancies that deliver small-for-gestational-age neonates
Abdel Azim, S., Wright, A., Sapantzoglou, I., Nicolaides, K. H. & Charakida, M., Jul 2022, In: Ultrasound in Obstetrics and Gynecology. 60, 1, p. 52-58 7 p.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler at 11–13 weeks' gestation in prediction of pre-eclampsia
Gana, N., Sarno, M., Vieira, N., Wright, A., Charakida, M. & Nicolaides, K. H., Jun 2022, In: Ultrasound in Obstetrics and Gynecology. 59, 6, p. 731-736 6 p.Research output: Contribution to journal › Article › peer-review
Preeclampsia
Magee, L. A., Nicolaides, K. H. & Von Dadelszen, P., 12 May 2022, In: New England Journal of Medicine. 386, 19, p. 1817-1832 16 p., 386.Research output: Contribution to journal › Review article › peer-review
Using ultrasound and angiogenic markers from a 19- to 23-week assessment to inform the subsequent diagnosis of preeclampsia
Lai, J., Syngelaki, A., Nicolaides, K. H., von Dadelszen, P. & Magee, L. A., Aug 2022, In: American Journal of Obstetrics and Gynecology. 227, 2, p. 294.e1-294.e11Research output: Contribution to journal › Article › peer-review
Maternal cardiac function in twin pregnancy at 19–23 weeks' gestation
Nunez, E., Huluta, I., Gallardo Arozena, M., Wright, A., Nicolaides, K. H. & Charakida, M., May 2022, In: Ultrasound in Obstetrics and Gynecology. 59, 5, p. 627-632 6 p.Research output: Contribution to journal › Article › peer-review
Ventilation-to-perfusion relationships and right-to-left shunt during neonatal intensive care in infants with congenital diaphragmatic hernia
Dassios, T., Shareef Arattu Thodika, F. M., Williams, E., Davenport, M., Nicolaides, K. H. & Greenough, A., Dec 2022, In: Pediatric Research. 92, 6, p. 1657-1662 6 p.Research output: Contribution to journal › Article › peer-review
Isolation and freezing of human peripheral blood mononuclear cells from pregnant patients
Efthymiou, A., Mureanu, N., Pemberton, R., Tai-macarthur, S., Mastronicola, D., Scottà, C., Lombardi, G., Nicolaides, K. H. & Shangaris, P., 18 Mar 2022, In: STAR Protocols. 3, 1, 101204.Research output: Contribution to journal › Article › peer-review
Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus
Fan, H. M., Mitchell, A. L., Bellafante, E., McIlvride, S., Primicheru, L. I., Giorgi, M., Eberini, I., Syngelaki, A., Lövgren-Sandblom, A., Jones, P., McCance, D., Sukumar, N., Periyathambi, N., Weldeselassie, Y., Hunt, K. F., Nicolaides, K. H., Andersson, D., Bevan, S., Seed, P. T. & Bewick, G. A. & 5 others, Bowe, J. E., Fraternali, F., Saravanan, P., Marschall, H. & Williamson, C., 1 Apr 2022, In: Diabetes. 71, 4, p. 837-852 16 p.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler at 35-37 weeks' gestation in pregnancies with small or growth-restricted fetuses
Abdel Azim, S., Sarno, M., Wright, A., Vieira, N., Charakida, M. & Nicolaides, K. H., Apr 2022, In: Ultrasound in Obstetrics and Gynecology. 59, 4, p. 483-489 7 p.Research output: Contribution to journal › Article › peer-review
Maternal Cardiac Function at Midgestation and Development of Preeclampsia
Gibbone, E., Huluta, I., Wright, A., Nicolaides, K. H. & Charakida, M., 4 Jan 2022, In: Journal of the American College of Cardiology. 79, 1, p. 52-62 11 p.Research output: Contribution to journal › Article › peer-review
Regulatory T Cells in Pregnancy Adverse Outcomes: A Systematic Review and Meta-Analysis
Green, S., Politis, M., Rallis, K. S., Saenz de Villaverde Cortabarria, A., Efthymiou, A., Mureanu, N., Dalrymple, K. V., Scottà, C., Lombardi, G., Tribe, R. M., Nicolaides, K. H. & Shangaris, P., 29 Oct 2021, In: Frontiers in Immunology. 12, 1 p., 737862.Research output: Contribution to journal › Article › peer-review
Preliminary experience with endoscopic laser surgery for severe twin-twin transfusion syndrome
Ville, Y., Hyett, J., Hecher, K. & Nicolaides, K., 26 Jan 1995, In: New England Journal of Medicine. 332, 4, p. 224-227 4 p.Research output: Contribution to journal › Article › peer-review
Regulatory T Cells in Pregnancy adverse Outcomes (Rutepo): A Systematic Review & Meta-Analysis
Green, S., Politis, M., Rallis, K., Saenz de Villaverde CORTABARRIA, A., Efthymiou , A., Mureanu, N., Dalrymple, K., Scotta, C., Lombardi, G., Tribe, R., Nicolaides, K. & Shangaris, P., 29 Oct 2021, In: Frontiers in immunology. 12, 737862.Research output: Contribution to journal › Article › peer-review
First trimester angiogenic and inflammatory factors in women with chronic hypertension and impact of blood pressure control: a case–control study
Nzelu, D., Nicolaides, K. H. & Kametas, N. A., Dec 2021, In: BJOG: An International Journal of Obstetrics and Gynaecology. 128, 13, p. 2171-2179 9 p.Research output: Contribution to journal › Article › peer-review
A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre-eclampsia: Compiled by the Pregnancy and Non-Communicable Diseases Committee of FIGO (the International Federation of Gynecology and Obstetrics)
Poon, L. C., Magee, L. A., Verlohren, S., Shennan, A., von Dadelszen, P., Sheiner, E., Hadar, E., Visser, G., Da Silva Costa, F., Kapur, A., McAuliffe, F., Nazareth, A., Tahlak, M., Kihara, A. B., Divakar, H., McIntyre, H. D., Berghella, V., Yang, H., Romero, R. & Nicolaides, K. H. & 2 others, Melamed, N. & Hod, M., Jul 2021, In: International Journal of Gynecology and Obstetrics. 154, S1, p. 3-31 29 p.Research output: Contribution to journal › Article › peer-review
Three-dimensional echocardiography and cardiac strain imaging in women with gestational diabetes mellitus
Company Calabuig, A. M., Nunez, E., Sánchez, A., Nicolaides, K. H., Charakida, M. & De Paco Matallana, C., Aug 2021, In: Ultrasound in Obstetrics and Gynecology. 58, 2, p. 278-284 7 p.Research output: Contribution to journal › Article › peer-review
Maternal cardiac function at 19–23 weeks' gestation in prediction of gestational diabetes mellitus
Gibbone, E., Wright, A., Vallenas Campos, R., Anzoategui, S., Nicolaides, K. H. & Charakida, M., Jun 2021, (E-pub ahead of print) In: Ultrasound in Obstetrics and Gynecology. 58, 1, 6 p.Research output: Contribution to journal › Article › peer-review
Reference Ranges for Pulsed-Wave Doppler of the Fetal Cardiac Inflow and Outflow Tracts from 13 to 36 Weeks’ Gestation
Zidere, V., Vigneswaran, T. V., Syngelaki, A., Charakida, M., Allan, L. D., Nicolaides, K. H., Simpson, J. M. & Akolekar, R., Sept 2021, In: Journal of The American Society of Echocardiography. 34, 9, p. 1007-1016.e10Research output: Contribution to journal › Article › peer-review
Relationship between ophthalmic artery Doppler and maternal cardiovascular function
Gibbone, E., Sapantzoglou, I., Nuñez-Cerrato, M. E., Wright, A., Nicolaides, K. H. & Charakida, M., May 2021, In: Ultrasound in Obstetrics and Gynecology. 57, 5, p. 733-738 6 p.Research output: Contribution to journal › Article › peer-review
Maternal cardiac function at 19–23 weeks' gestation in prediction of pre-eclampsia
Gibbone, E., Wright, A., Vallenas Campos, R., Sanchez Sierra, A., Nicolaides, K. H. & Charakida, M., May 2021, In: Ultrasound in Obstetrics and Gynecology. 57, 5, p. 739-747 9 p.Research output: Contribution to journal › Article › peer-review
Impact of gestational diabetes mellitus on fetal cardiac morphology and function: cohort comparison of second- and third-trimester fetuses
Yovera, L., Zaharia, M., Jachymski, T., Velicu-Scraba, O., Coronel, C., de Paco Matallana, C., Georgiopoulos, G., Nicolaides, K. H. & Charakida, M., 2020, (Accepted/In press) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Fetal cardiac function at 35–37 weeks' gestation in pregnancies that subsequently develop pre-eclampsia
Semmler, J., Garcia-Gonzalez, C., Sanchez Sierra, A., Gallardo Arozena, M., Nicolaides, K. H. & Charakida, M., 2020, (Accepted/In press) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Influence of birth weight on fetal cardiac indices at 35–37 weeks' gestation
Semmler, J., Abdel-Azim, S., Anzoategui, S., Zhang, H., Nicolaides, K. H. & Charakida, M., 2020, (Accepted/In press) In: Ultrasound in Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Early Detection of Preeclampsia Using Circulating Small non-coding RNA
Yoffe, L., Gilam, A., Yaron, O., Polsky, A., Farberov, L., Syngelaki, A., Nicolaides, K., Hod, M. & Shomron, N., 1 Dec 2018, In: Scientific Reports. 8, 1, 3401.Research output: Contribution to journal › Article › peer-review
Aspirin delays the development of preeclampsia
Wright, D. & Nicolaides, K. H., Jun 2019, In: American Journal of Obstetrics and Gynecology. 220, 6, p. 580.e1-580.e6Research output: Contribution to journal › Article › peer-review
First trimester serum angiogenic and anti-angiogenic factors in women with chronic hypertension for the prediction of preeclampsia
Nzelu, D., Biris, D., Karampitsakos, T., Nicolaides, K. K. & Kametas, N. A., Apr 2020, In: American Journal of Obstetrics and Gynecology. 222, 4, p. 374.e1-374.e9Research output: Contribution to journal › Article › peer-review
The competing risk approach for prediction of preeclampsia
Wright, D., Wright, A. & Nicolaides, K. H., Jul 2020, In: American Journal of Obstetrics and Gynecology. 223, 1, p. 12-23.e7Research output: Contribution to journal › Review article › peer-review
First trimester inflammatory mediators in women with chronic hypertension
Nzelu, D., Dumitrascu-Biris, D., Karampitsakos, T., Nicolaides, K. K. & Kametas, N. A., 1 Sept 2020, In: Acta Obstetricia et Gynecologica Scandinavica. 99, 9, p. 1198-1205 8 p.Research output: Contribution to journal › Article › peer-review
Clinical validation of bioreactance for the measurement of cardiac output in pregnancy
Ling, H. Z., Gallardo-Arozena, M., Company-Calabuig, A. M., Nicolaides, K. H. & Kametas, N. A., 1 Oct 2020, In: Anaesthesia. 75, 10, p. 1307-1313 7 p.Research output: Contribution to journal › Article › peer-review
Impact of new definitions of preeclampsia at term on identification of adverse maternal and perinatal outcomes
Lai, J., Syngelaki, A., Nicolaides, K. H., von Dadelszen, P. & Magee, L. A., 2020, (Accepted/In press) In: American Journal of Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
Ophthalmic artery Doppler in prediction of pre-eclampsia at 35–37 weeks' gestation
Sarno, M., Wright, A., Vieira, N., Sapantzoglou, I., Charakida, M. & Nicolaides, K. H., 1 Nov 2020, In: Ultrasound in Obstetrics and Gynecology. 56, 5, p. 717-724 8 p.Research output: Contribution to journal › Article › peer-review
The value of three-dimensional ultrasound in identifying Mullerian anomalies at risk of adverse pregnancy outcomes
Negm, S. M., Kamel, R. A., El-Zayat, H. A., Elbigawy, A. F., El-Toukhy, M. M., Amin, A. H. & Nicolaides, K. H., 1 Jan 2020, (Accepted/In press) In: Journal of Maternal-Fetal and Neonatal Medicine.Research output: Contribution to journal › Article › peer-review
Research

Prenatal ThERapy for SIckle CelL disEaSe (PERICLES)
To generate new knowledge about stakeholders' views on prenatal therapy for Sickle Cell Disease, identify ethical issues and establish protocols for support.
Project status: Ongoing

Regulatory T Cells in Pregnancy Adverse Outcomes (Rutepo)
Tregs play a critical role in maintaining immune tolerance during pregnancy, and their dysfunction has been associated with pregnancy complications.
Project status: Ongoing

Maternal Hypertension
The Hypertension group strategy focuses on improving outcomes for women with hypertension in pregnancy

Vlachodimitropoulou Group
Vlachodimitropoulou Group - our lab stands at the forefront of maternal and fetal health. With a specialized focus on fetal therapy and maternal and fetal hematology.
News
King's researchers evaluate effectiveness of placental growth factor measurement in mid-pregnancy
Among pregnancies with clinical risk factors for pre-eclampsia or fetal growth restriction, PlGF in mid-pregnancy is unhelpful in identifying women and babies...

Scheduled childbirth could cut pre-eclampsia risk by 50%
Latest analysis of data shows that delivering babies earlier at term minimises occurrence of pre-eclampsia in women at increased risk of this important...

Events

Fifth Annual Niki Marangou Memorial Lecture: 'Life before Birth'
Join us for the fifth Niki Marangou Annual Memorial Lecture: Professor Kypros Nicolaides
Please note: this event has passed.