Biography
Dr Joseph Wanford is a 'Professor Anthony Mellows Research Fellow' studying interactions between the human pathogen Klebsiella pneumoniae and the host. Dr Wanford is particularly interested in how Klebsiella switch ON and OFF their virulence determinants to resist killing by host phagocytes. A current interest is the mechanisms by which Klebsiella genetically regulate expression of the polysaccharide capsule, a major virulence factor and candidate vaccine antigen.
Research
Wanford Group
The Wanford lab employs genomic, and wet lab infection biology techniques to study: (1) how Kp regulate expression of its major virulence factor, a slimy layer surrounding the pathogen called the polysaccharide capsule, and (2) how both the capsule and other accessory genes modulate interaction of Kp with host cells
News
Bacteria that cause dysentery also actively block body's ability to fight the infection
Scientists reveal that Shigella tricks the immune system, hindering the body’s ability to mount an effective immune response against infection
Research
Wanford Group
The Wanford lab employs genomic, and wet lab infection biology techniques to study: (1) how Kp regulate expression of its major virulence factor, a slimy layer surrounding the pathogen called the polysaccharide capsule, and (2) how both the capsule and other accessory genes modulate interaction of Kp with host cells
News
Bacteria that cause dysentery also actively block body's ability to fight the infection
Scientists reveal that Shigella tricks the immune system, hindering the body’s ability to mount an effective immune response against infection