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Joseph Wanford

Dr Joseph Wanford

Research Fellow

Biography

Dr Joseph Wanford is a 'Professor Anthony Mellows Research Fellow' studying interactions between the human pathogen Klebsiella pneumoniae and the host. Dr Wanford is particularly interested in how Klebsiella switch ON and OFF their virulence determinants to resist killing by host phagocytes. A current interest is the mechanisms by which Klebsiella genetically regulate expression of the polysaccharide capsule, a major virulence factor and candidate vaccine antigen.

    Research

    1908x558_abstract-bacteria
    Wanford Group

    The Wanford lab employs genomic, and wet lab infection biology techniques to study: (1) how Kp regulate expression of its major virulence factor, a slimy layer surrounding the pathogen called the polysaccharide capsule, and (2) how both the capsule and other accessory genes modulate interaction of Kp with host cells

    Hero_Microbes_RIG-thumbnail
    Microbes in Health & Disease

    The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.

    News

    Bacteria that cause dysentery also actively block body's ability to fight the infection

    Scientists reveal that Shigella tricks the immune system, hindering the body’s ability to mount an effective immune response against infection

    Dysentry

      Research

      1908x558_abstract-bacteria
      Wanford Group

      The Wanford lab employs genomic, and wet lab infection biology techniques to study: (1) how Kp regulate expression of its major virulence factor, a slimy layer surrounding the pathogen called the polysaccharide capsule, and (2) how both the capsule and other accessory genes modulate interaction of Kp with host cells

      Hero_Microbes_RIG-thumbnail
      Microbes in Health & Disease

      The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.

      News

      Bacteria that cause dysentery also actively block body's ability to fight the infection

      Scientists reveal that Shigella tricks the immune system, hindering the body’s ability to mount an effective immune response against infection

      Dysentry