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Jill Kucab

Dr Jill Kucab PhD

Research Fellow

Contact details

Biography

Dr Jill Kucab obtained a BSc in Biochemistry from North Carolina State University and an MSc in Experimental Medicine from the University of British Columbia. In the early years of her career, Jill worked in preclinical drug discovery, studying kinase inhibitors as potential therapeutics for cancer. Later, as Jill became more interest in how cancer develops, she pursued a PhD in Environmental Carcinogenesis at the Institute of Cancer Research in London, studying mutations in TP53 caused by environmental contaminants.

In 2013, Jill began her postdoctoral work with Professor David Phillips at King's. As part of the COMSIG consortium (2013–2017), both collaborated with scientists from the Sanger Institute and the University of Cambridge to determine the genome-wide mutational signatures of over 40 environmental agents in human induced pluripotent stem cells.

Currently Jill is a Research Fellow working on a CRUK Grand Challenge project, 'Mutographs of Cancer', using human tissue-derived organoid models to expand upon our previous work. By identifying the mutational fingerprints of environmental carcinogens in experimental systems, Jill hopes to better understand the contribution of these factors to the mutations we observe human cancer.

    Research

    GENETIC & ENVIRONMENTAL TOXICOLOGY
    Environmental Carcinogenesis Research Group

    We study environmental carcinogens and the mechanisms by which they exert their deleterious biological effects, in order to better understand the causes of cancer and improve strategies for cancer prevention.

      Research

      GENETIC & ENVIRONMENTAL TOXICOLOGY
      Environmental Carcinogenesis Research Group

      We study environmental carcinogens and the mechanisms by which they exert their deleterious biological effects, in order to better understand the causes of cancer and improve strategies for cancer prevention.