Our Research Group studies environmental carcinogens and the mechanisms by which they exert their deleterious biological effects, in order to better understand the causes of cancer and improve strategies for cancer prevention. We study pathways of metabolic activation of carcinogens to premutagenic species and analyse the mutations that these agents induce in human cells in culture. We are exploring the utility of 3D cultures, called organoids, as test systems and generate mutational signatures across the whole genome that can be compared with those detected in human tumours.