Professor Jeremy Carlton Research fellows Supervisors Wellcome Trust Senior Research Fellow Research subject areas Cancer Contact details jeremy.carlton@kcl.ac.uk +44 (0) 20 3796 3791
ESCRT-III function in membrane fission and repair ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication Interview with the 2022 Hooke medal winner Jeremy Carlton LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion AKTIP interacts with ESCRT i and is needed for the recruitment of ESCRT III subunits to the midbody Exploitation of the Secretory Pathway by SARS-CoV-2 Envelope CDK1 controls CHMP7-dependent nuclear envelope reformation Membrane and organelle dynamics during cell division The ESCRT-machinery: closing holes and expanding roles CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation Capping protein regulates actin dynamics during cytokinetic midbody maturation An apical MRCK-driven morphogenetic pathway controls epithelial polarity ESCRT-dependent control of membrane remodelling during cell division PKCϵ switches Aurora B specificity to exit the abscission checkpoint ESCRT-III controls nuclear envelope reformation The ESCRT machinery: new roles at new holes Membrane binding by CHMP7 coordinates ESCRT-III dependent nuclear envelope reformation ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release Phosphoinositides in the Mammalian Endo-lysosomal Network ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C The ESCRT machinery: a cellular apparatus for sorting and scission Essential Role of hIST1 in Cytokinesis SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment Coincidence detection in phosphoinositide signaling Parallels between cytokinesis and retroviral budding: A role for the ESCRT machinery The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation Membrane targeting by pleckstrin homology domains. Sorting Nexins - unifying trends and new perspectives. The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. Sorting Nexins Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. The ESCRT machinery: new functions in viral and cellular biology: new functions in viral and cellular biology The retromer component SNX1 regulates endosomal retrieval of the cation-independent mannose 6-phosphate receptor CI-MPR View all publications
18 July 2024 School pupils gain hands-on experience in cancer research Budding young scientists from schools around London tried out their skills in cancer research at…