My work is focused on the development and application of diffusion MRI methods, particularly those that relate to the characterisation of white matter and its connectivity. I have worked particularly on:

• the design of acquisition schemes for high angular resolution diffusion imaging (HARDI)
• estimating fibre orientations in a crossing fibre context via spherical deconvolution
• probabilistic tractography methods and related applications such as Track Density Imaging (TDI), Anatomically Constrained Tractography (ACT), and spherical deconvolution informed filtering of tracks (SIFT)
• Apparent Fibre Density (AFD) methods for group-wise fixel-based analysis of whole brain diffusion MRI data (fixel: fibre element - a fibre population within an imaging voxel)
• advocating the use of higher-order models for clinical applications, particularly neurosurgical planning

Much of my research output is available for use in the open-source software package MRtrix. I was also involved in the development of Medtronic’s Stealth Tractography package, released in 2023 for use on the StealthStation S8 neurosurgical navigation system.I am currently interested in the acquisition and modelling of diffusion MRI data over the fetal, neonatal and early childhood period, and applying existing analysis methods to large datasets including the developing Human Connectome Project (dHCP).I completed my PhD in 2003 under the supervision of Alan Connelly and Fernando Calamante in the UCL Institute of Child Health, In 2005, I joined the Brain Research Institute in Melbourne, Australia, which was later amalgamated into the Florey Institutes of Neuroscience and Mental Health. In 2013, I joined the School of Biomedical Engineering and Imaging Sciences at King's College London, working within the Department of Perinatal Imaging and Health, located in St Thomas's Hospital, London.