My research is directed towards understanding the molecular mechanisms regulating directed cell movements and adhesion turnover. Using a combination of optical microscopy techniques including widefield phase contrast/fluorescence time-lapse, LS confocal imaging, FRAP, TIRF, FRET-FLIM and superesolution microscopy, the work of our group examines the dynamics of key proteins involved in forming and breaking up adhesive podosomes and invadopodia in living cells as they migrate over and through selected extracellular matrices.