My team studies the gene regulation mechanisms that underlie proper development of neurons. In particular, we are interested in understanding how post-transcriptional mechanisms such as alternative pre-mRNA splicing influence the maturation of neurons. Our general approach involves developing sophisticated computational methods that employ cross-disciplinary AI/ML and advanced statistical approaches to analyse multi-omics dataset at the level of whole-brain or individual neurons. 

Please see my Research Staff Profile for more detail

Find out more about my research:

• Hamid Lab

Key publications:

• Hamid et al. (2022) Functional Annotation of Custom Transcriptomes. Methods in Molecular Biology. 
• Gordon et al. (2021). A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons. Nat. Commun.
• Hamid and Makeyev. (2017). A mechanism underlying position-specific regulation of alternative splicing. Nucleic Acids Res.
• Egeland et al., 2017. Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression. Transl Psychiatry.

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Key collaborators:

• Professor Eugene Makeyev, King's College London
• Professor Oscar Marín, King's College London
• Professor Beatriz Rico, King's College London