
Professor Dominic Ffytche
Professor of Visual Psychiatry
Research interests
- Ageing
- Psychiatry
Biography
Dominic Ffytche is Professor of Visual Psychiatry at the Institute of Psychiatry, Psychology & Neuroscience at King's College London. He is Lead Consultant Psychiatrist to the Visual Perceptual Disorder clinic at the South London and Maudsley NHS Foundation Trust, a national specialist service for patients with visual hallucinations.
He researches brain mechanisms of vision and how they go wrong to cause visual hallucinations, visual illusions and related symptoms and treatments for such experiences. He has published over 100 articles in the scientific and lay literature with over 4,000 academic citations.
He plays a leading role in patient and public education for Charles Bonnet Syndrome (visual hallucinations in eye disease) as medical advisor to Esme’s Umbrella and has helped develop information resources on visual hallucinations for the NHS, charity sector and eye-health professionals.
Aprosopsia: a novel metamorphopsia variant occurring in Parkinson's disease psychosis
Reddy, A. B. S., Pisani, S., Kuruppu, S., Bhattacharyya, S., Ffytche, D. H. & Velayudhan, L., 19 Mar 2025, In: Journal of Neurology. 272, 4, p. 277 277.Research output: Contribution to journal › Article › peer-review
Aprosopsia: a novel metamorphopsia variant occurring in Parkinson’s disease psychosis
Reddy, A. B. S., Pisani, S., Kuruppu, S., Bhattacharyya, S., ffytche, D. H. & Velayudhan, L., Apr 2025, In: Journal of Neurology. 272, 4, 277.Research output: Contribution to journal › Letter › peer-review
Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis
Pisani, S., Velayudhan, L., Aarsland, D., Ray Chaudhuri, K., Ballard, C., Ffytche, D. & Bhattacharyya, S., 31 Mar 2025, In: BMJ mental health. 28, 1Research output: Contribution to journal › Article › peer-review
Functional and connectivity correlates associated with Parkinson's disease psychosis: a systematic review
Pisani, S., Gunasekera, B., Lu, Y., Vignando, M., Ffytche, D., Aarsland, D., Chaudhuri, K. R., Ballard, C., Lee, J.-Y., Kim, Y. K., Velayudhan, L. & Bhattacharyya, S., 2024, In: Brain Communications. 6, 6, p. fcae358 fcae358.Research output: Contribution to journal › Review article › peer-review
Functional and connectivity correlates associated with Parkinson’s disease psychosis: a systematic review
Pisani, S., Gunasekera, B., Lu, Y., Vignando, M., Ffytche, D., Aarsland, D., Chaudhuri, K. R., Ballard, C., Lee, J. Y., Kim, Y. K., Velayudhan, L. & Bhattacharyya, S., 2024, In: Brain Communications. 6, 6, fcae358.Research output: Contribution to journal › Review article › peer-review
Parkinson’s disease psychosis associated with accelerated multidomain cognitive decline
Pisani, S., Gosse, L., Aarsland, D., Ray Chaudhuri, K., Ballard, C., Ffytche, D., Velayudhan, L. & Bhattacharyya, S., 23 Jul 2024, In: BMJ mental health. 27, 1, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
Visual mismatch negativity in Parkinson’s psychosis and potential for testing treatment mechanisms
Vignando, M., Ffytche, D., Mazibuko, N., Palma, G., Montagnese, M., Dave, S., Nutt, D., Gabay, A., Tai, Y., Batzu, L., Leta, V., Williams Gray, C., Chaudhuri, K. & Mehta, M., 14 May 2024, (Accepted/In press) In: Brain Communications.Research output: Contribution to journal › Article › peer-review
Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion
Guu, T.-W., Brem, A.-K., Albertyn, C. P., Kandangwa, P., Aarsland, D. & Ffytche, D., May 2024, In: Alzheimer's & Dementia. 20, 5, p. 3211-3218 8 p.Research output: Contribution to journal › Article › peer-review
Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion
Guu, T.-W., Brem, A.-K., Albertyn, C., Kandangwa, P., Aarsland, D. & Ffytche, D., 18 Mar 2024, In: Alzheimer's & Dementia.Research output: Contribution to journal › Article › peer-review
Cognitive and executive impairments in Parkinson's disease psychosis: a Bayesian meta-analysis
Pisani, S., Gosse, L., Wieretilo, R., Ffytche, D., Velayudhan, L. & Bhattacharyya, S., 19 Jul 2023, (E-pub ahead of print) In: Journal of neurology, neurosurgery, and psychiatry. jnnp-2022-331028.Research output: Contribution to journal › Review article › peer-review
Grey matter volume loss in Parkinson’s Disease Psychosis and its relationship with serotonergic gene expression: A meta-analysis
Pisani, S., Gunasekera, B., Lu, Y., Vignando, M., Ffytche, D., Aarsland, D., Chaudhuri, K. R., Ballard, C., Lee, J.-Y., Kim, Y. K., Velayudhan, L. & Bhattacharyya, S., Apr 2023, In: Neuroscience and Biobehavioral Reviews. 147, 105081.Research output: Contribution to journal › Review article › peer-review
Neuropathological correlates of neuropsychiatric symptoms in dementia
Gibson, L. L., Grinberg, L. T., ffytche, D., Leite, R. E. P., Rodriguez, R. D., Ferretti-Rebustini, R. E. L., Pasqualucci, C. A., Nitrini, R., Jacob-Filho, W., Aarsland, D. & Suemoto, C. K., Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1372-1382 11 p.Research output: Contribution to journal › Article › peer-review
Wearable devices: underrepresentation in the ageing society
Guu, T. W., Muurling, M., Khan, Z., Kalafatis, C., Aarsland, D., ffytche, D. & Brem, A. K., Jun 2023, In: The Lancet Digital Health. 5, 6, p. e336-e337Research output: Contribution to journal › Comment/debate › peer-review
Wearable devices: underrepresentation in the ageing society
Guu, T.-W., Muurling, M., Khan, Z., Kalafatis, C., Aarsland, D., Ffytche, D. & Brem, A.-K., Jun 2023, In: The Lancet. Digital health. 5, 6, p. e336-e337Research output: Contribution to journal › Article › peer-review
Cognitive and visual processing performance in Parkinson's disease patients with vs without visual hallucinations: A meta-analysis
Montagnese, M., Vignando, M., ffytche, D. & Mehta, M. A., Jan 2022, In: Cortex. 146, p. 161-172 12 p.Research output: Contribution to journal › Article › peer-review
Investigation of structural brain changes in Charles Bonnet Syndrome
Firbank, M. J., daSilva Morgan, K., Collerton, D., Elder, G. J., Parikh, J., Olsen, K., Schumacher, J., ffytche, D. & Taylor, J. P., Jan 2022, In: NeuroImage: Clinical. 35, 103041.Research output: Contribution to journal › Article › peer-review
Light, sleep-wake rhythm, and behavioural and psychological symptoms of dementia in care home patients: Revisiting the sundowning syndrome
Guu, T.-W., Aarsland, D. & Ffytche, D., May 2022, In: International Journal of Geriatric Psychiatry. 37, 5, GPS5712.Research output: Contribution to journal › Review article › peer-review
The medial occipital longitudinal tract supports early stage encoding of visuospatial information
Beyh, A., Dell' Acqua, F., Cancemi, D., De Santiago Requejo, F., Ffytche, D. & Catani, M., Dec 2022, In: Communications Biology. 5, 1, 318.Research output: Contribution to journal › Article › peer-review
Transcranial Direct Current Stimulation in the Treatment of Visual Hallucinations in Charles Bonnet Syndrome: A Randomized Placebo-Controlled Crossover Trial
daSilva Morgan, K., Schumacher, J., Collerton, D., Colloby, S., Elder, G. J., Olsen, K., ffytche, D. H. & Taylor, J. P., Dec 2022, In: Ophthalmology. 129, 12, p. 1368-1379 12 p.Research output: Contribution to journal › Article › peer-review
Visual hallucinations in Lewy body disease: pathophysiological insights from phenomenology
D’Antonio, F., Boccia, M., Di Vita, A., Suppa, A., Fabbrini, A., Canevelli, M., Caramia, F., Fiorelli, M., Guariglia, C., Ferracuti, S., de Lena, C., Aarsland, D. & ffytche, D., Jul 2022, In: Journal of Neurology. 269, 7, p. 3636-3652 17 p.Research output: Contribution to journal › Article › peer-review
A century of prosopometamorphopsia studies
Blom, J. D., Meulen, B. T., Dool, J. & Ffytche, D., 13 Mar 2021, (Accepted/In press) In: Cortex; a journal devoted to the study of the nervous system and behavior.Research output: Contribution to journal › Article › peer-review
Cerebellar Correlates of Visual Hallucinations in Parkinson’s Disease and Charles Bonnet Syndrome
Lawn, T. & Ffytche, D., Feb 2021, In: Cortex. 135, p. 311-325 15 p.Research output: Contribution to journal › Article › peer-review
Cerebellar involvement in hallucinations may transcend clinical conditions and perceptual modalities
Lawn, T. & ffytche, D., Oct 2021, In: Cortex. 143, p. 290-294 5 p.Research output: Contribution to journal › Article › peer-review
Cognition, hallucination severity and hallucination-specific insight in neurodegenerative disorders and eye disease
Montagnese, M., Vignando, M., Collerton, D., Ffytche, D., Mosimann, U. P., Taylor, J.-P., daSilva Morgan, K. & Urwyler, P., 2 Aug 2021, (E-pub ahead of print) In: Cognitive Neuropsychiatry. 17 p.Research output: Contribution to journal › Article › peer-review
Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome
Puledda, F., O'Daly, O., Schankin, C., Ffytche, D., Williams, S. C. & Goadsby, P. J., May 2021, In: Human Brain Mapping. 42, 7, p. 2032-2044 13 p.Research output: Contribution to journal › Article › peer-review
Localised increase in regional cerebral perfusion in patients with visual snow syndrome: A pseudo-continuous arterial spin labelling study
Puledda, F., Schankin, C. J., O'Daly, O., Ffytche, D., Eren, O., Karsan, N., Williams, S. C. R., Zelaya, F. & Goadsby, P. J., 1 Sept 2021, In: Journal of Neurology, Neurosurgery and Psychiatry. 92, 9, p. 918-926 9 p.Research output: Contribution to journal › Article › peer-review
Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations
Vignando, M., Ffytche, D., Lewis, S. J. G., Lee, P. H., Chung, S. J., Weil, R. S., Hu, M., Mackay, C., Griffanti, L., Pins, D., Dujardin, K., Jardri, R., Paul Taylor, J., Firbank, M. J., McAlonan, G., Ka-Fung Mak, H., Ho, S.-L. & Mehta, M., 14 Dec 2021, (Accepted/In press) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson’s disease
Oikonomou, P., van Wamelen, D. J., Weintraub, D., Aarsland, D., Ffytche, D., Martinez-Martin, P., Rodriguez-Blazquez, C., Leta, V., Borley, C., Sportelli, C., Trivedi, D., Podlewska, A. M., Rukavina, K., Rizos, A., Lazcano-Ocampo, C. & Ray Chaudhuri, K., May 2021, In: Brain and Behavior. 11, 5, e02086.Research output: Contribution to journal › Article › peer-review
Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease
Jaramillo-Jimenez, A., Suarez-Revelo, J. X., Ochoa-Gomez, J. F., Carmona Arroyave, J. A., Bocanegra, Y., Lopera, F., Buriticá, O., Pineda-Salazar, D. A., Moreno Gómez, L., Tobón Quintero, C. A., Borda, M. G., Bonanni, L., Ffytche, D. H., Brønnick, K. & Aarsland, D., Mar 2021, In: Clinical Neurophysiology. 132, 3, p. 756-764 9 p.Research output: Contribution to journal › Article › peer-review
The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial
Gilleen, J., Nottage, J., Yakub, F., Kerins, S., Valdearenas, L., Uz, T., Lahu, G., Tsai, M., Ogrinc, F., Williams, S. C., Ffytche, D., Mehta, M. A. & Shergill, S. S., Jan 2021, In: Journal of Psychopharmacology. 35, 1, p. 15-22 8 p.Research output: Contribution to journal › Article › peer-review
A Preliminary Investigation of the Views of People With Parkinson's (With and Without Psychosis) and Caregivers on Participating in Clinical Trials During the Covid-19 Pandemic: An Online Survey
McGoohan, K., Amjad, A., Ratcliffe, N., Bhattacharyya, S., Granville, G., Sullivan, M., Gosden, L., Aarsland, D., Chaudhuri, K. R., Ffytche, D., Ballard, C. & Velayudhan, L., 23 Dec 2020, In: Frontiers in Psychiatry. 11, p. 602480Research output: Contribution to journal › Article › peer-review
A preliminary investigation of the views of people with Parkinson’s disease psychosis and caregivers on participating in clinical trials during the COVID-19 pandemic: an online survey
McGoohan, K., Amjad, A., Ratcliffe, N., Bhattacharyya, S., Granville, G., Sullivan, M., Gosden, L., Aarsland, D., Chaudhuri, K., Ffytche, D., Ballard, C. & Velayudhan, L., 23 Dec 2020, In: Frontiers in Psychiatry.Research output: Contribution to journal › Article › peer-review
Drug and Disease Effects in Parkinson's Psychosis: Revisiting the Role of Dopamine
Dave, S., Weintraub, D., Aarsland, D. & ffytche, D. H., 1 Jan 2020, In: Movement Disorders Clinical Practice. 7, 1, p. 32-36 5 p.Research output: Contribution to journal › Article › peer-review
Hallucinations and other psychotic experiences across diagnoses: A comparison of phenomenological features
Schutte, M. J. L., Linszen, M. M. J., Marschall, T. M., ffytche, D. H., Koops, S., van Dellen, E., Heringa, S. M., Slooter, A. J. C., Teunisse, R., van den Heuvel, O. A., Lemstra, A. W., Foncke, E. M. J., Slotema, C. W., de Jong, J., Rossell, S. L. & Sommer, I. E. C., Oct 2020, In: Psychiatry Research. 292, 113314.Research output: Contribution to journal › Article › peer-review
Hallucinations in Older Adults: A Practical Review
Badcock, J. C., Larøi, F., Kamp, K., Kelsall-Foreman, I., Bucks, R. S., Weinborn, M., Begemann, M., Taylor, J. P., Collerton, D., O'Brien, J. T., El Haj, M., Ffytche, D. & Sommer, I. E., 1 Dec 2020, In: Schizophrenia bulletin. 46, 6, p. 1382-1395 14 p.Research output: Contribution to journal › Article › peer-review
Insular and occipital changes in visual snow syndrome: a BOLD fMRI and MRS study
Puledda, F., Ffytche, D., Lythgoe, D. J., O'Daly, O., Schankin, C., Williams, S. C. R. & Goadsby, P. J., 10 Mar 2020, (E-pub ahead of print) In: Annals of Clinical and Translational Neurology. 7, 3, p. 296-306 11 p.Research output: Contribution to journal › Article › peer-review
Occipital cortex and cerebellum gray matter changes in visual snow syndrome
Puledda, F., Bruchhage, M., O'Daly, O., Ffytche, D., Williams, S. C. R. & Goadsby, P. J., 29 Sept 2020, In: Neurology. 95, 13, p. e1792-e1799Research output: Contribution to journal › Article › peer-review
Resting-state qEEG Alpha/Theta ratio related to neuropsychological test performance in Parkinson’s Disease
Aarsland, D., Ffytche, D. & Jaramillo-Jimenez, A., 18 Nov 2020, (Accepted/In press) In: Clinical Neurophysiology.Research output: Contribution to journal › Article › peer-review
Visual hallucinations in neurological and ophthalmological disease: Pathophysiology and management
O'Brien, J., Taylor, J. P., Ballard, C., Barker, R. A., Bradley, C., Burns, A., Collerton, D., Dave, S., Dudley, R., Francis, P., Gibbons, A., Harris, K., Lawrence, V., Leroi, I., McKeith, I., Michaelides, M., Naik, C., O'Callaghan, C., Olsen, K. & Onofrj, M. & 7 others, Pinto, R., Russell, G., Swann, P., Thomas, A., Urwyler, P., Weil, R. S. & Ffytche, D., 1 May 2020, In: Journal of Neurology, Neurosurgery and Psychiatry. 91, 5, p. 512-519 8 p., 322702.Research output: Contribution to journal › Review article › peer-review
Drug and disease effects in Parkinson’s psychosis: revisiting the role of dopamine
Dave, S., Weintraub, D., Aarsland, D. & Ffytche, D. H., 14 Sept 2019, (Accepted/In press) In: Movement Disorders Clinical Practice.Research output: Contribution to journal › Article › peer-review
Imaging the Visual Network in the Migraine Spectrum
Puledda, F., Ffytche, D., O'Daly, O. & Goadsby, P. J., 13 Dec 2019, In: Frontiers in Neurology. 10, p. 1325 1325.Research output: Contribution to journal › Review article › peer-review
Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management.. Journal of neurology, neurosurgery, and psychiatry
O'Brien, J., Taylor, J. P., Ballard, C., Barker, C., Bradley, C., Burns, A., Collerton, D., Dave, S., Dudley, R., Francis, P., Gibbons, A., Harris, K., Lawrence, V., Leroi, I., McKeith, I., Michaelides, M., Olson, K., Naik, C., O'Callaghan, C. & Onofri, M. & 6 others, Pinto, R., Russell, G., Swann, P., Urwyler, P., Weil, R. & Ffytche, D., 1 Jan 2019, In: Journal of Neurology, Neurosurgery and Psychiatry. 91, 5Research output: Contribution to journal › Article › peer-review
Amyloid-β and Parkinson’s disease
Lim, E. W., Aarsland, D., Ffytche, D., Taddei, R. N., van Wamelen, D. J., Wan, Y. M., Tan, E. K., Ray Chaudhuri, K. & Kings Parcog groupMDS Nonmotor study group, 19 Oct 2018, (Accepted/In press) In: Journal of Neurology.Research output: Contribution to journal › Article › peer-review
Assessment and Management of Neuropsychiatric Symptoms in Parkinson's Disease
Mueller, C., Rajkumar, A. P., Wan, Y. M., Velayudhan, L., ffytche, D., Chaudhuri, K. R. & Aarsland, D., Jul 2018, In: CNS Drugs. 32, 7, p. 621-635 15 p.Research output: Contribution to journal › Article › peer-review
Successful management of persistent distressing neuropsychiatric symptoms by clozapine in a patient suffering from dementia with Lewy bodies
Bhamra, M., Rajkumar, A. P., Ffytche, D. H. & Kalafatis, C., 26 Jul 2018, In: BMJ case reports. 2018Research output: Contribution to journal › Article › peer-review
The utility and application of electrophysiological methods in the study of visual hallucinations
daSilva Morgan, K., Elder, G. J., ffytche, D. H., Collerton, D. & Taylor, J.-P., 6 Sept 2018, (E-pub ahead of print) In: Clinical Neurophysiology. 129, 11, p. 2361-2371Research output: Contribution to journal › Review article › peer-review
Visual Hallucinations in Dementia and Parkinson’s Disease: A Qualitative Exploration of Patient and Caregiver Experiences
Renouf, S., ffytche, D., Pinto, R., Murray, J. & Lawrence, V., Oct 2018, In: International Journal of Geriatric Psychiatry. 33, 10, p. 1327-1334 8 p.Research output: Contribution to journal › Article › peer-review
Accuracy of Clinical Diagnosis of Dementia with Lewy Bodies versus Neuropathology
Skogseth, R. E., Hortobágyi, T., Soennesyn, H., Chwiszczuk, L., Ffytche, D., Rongve, A., Ballard, C. & Aarsland, D., 14 Aug 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 59, 4, p. 1139-1152 14 p.Research output: Contribution to journal › Article › peer-review
Cognitive decline in Parkinson disease
Aarsland, D., Creese, B., Politis, M., Ray Chaudhuri, K., Ffytche, D. H., Weintraub, D. & Ballard, C., Apr 2017, In: Nature Reviews Neurology. 13, p. 217–231Research output: Contribution to journal › Article › peer-review
New Therapeutic Strategies for Lewy Body Dementias
Velayudhan, L., Ffytche, D., Ballard, C. & Aarsland, D., Sept 2017, In: CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. 17, 9, p. 68Research output: Contribution to journal › Review article › peer-review
Research

Cannabidiol for Parkinson’s Disease Psychosis (CAN-PDP) Trial
Multi-centre trial of cannabidiol (CBD) for the treatment of Parkinson's disease psychosis
Project status: Ongoing

Centre for Healthy Brain Ageing
The centre supports the development of biomarkers in neurocognitive disorders, and novel strategies to support the early diagnosis of AD and related disorders.
News
Visual mismatch negativity identified as a mechanism of Parkinson's disease psychosis
Reduced brain activity responding to unpredicted visual changes is a marker of psychosis in Parkinson’s disease and a potential therapeutic target

Aprosopsia: a novel metamorphopsia variant occurring in Parkinson's disease psychosis
Reddy, A. B. S., Pisani, S., Kuruppu, S., Bhattacharyya, S., Ffytche, D. H. & Velayudhan, L., 19 Mar 2025, In: Journal of Neurology. 272, 4, p. 277 277.Research output: Contribution to journal › Article › peer-review
Aprosopsia: a novel metamorphopsia variant occurring in Parkinson’s disease psychosis
Reddy, A. B. S., Pisani, S., Kuruppu, S., Bhattacharyya, S., ffytche, D. H. & Velayudhan, L., Apr 2025, In: Journal of Neurology. 272, 4, 277.Research output: Contribution to journal › Letter › peer-review
Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis
Pisani, S., Velayudhan, L., Aarsland, D., Ray Chaudhuri, K., Ballard, C., Ffytche, D. & Bhattacharyya, S., 31 Mar 2025, In: BMJ mental health. 28, 1Research output: Contribution to journal › Article › peer-review
Functional and connectivity correlates associated with Parkinson's disease psychosis: a systematic review
Pisani, S., Gunasekera, B., Lu, Y., Vignando, M., Ffytche, D., Aarsland, D., Chaudhuri, K. R., Ballard, C., Lee, J.-Y., Kim, Y. K., Velayudhan, L. & Bhattacharyya, S., 2024, In: Brain Communications. 6, 6, p. fcae358 fcae358.Research output: Contribution to journal › Review article › peer-review
Functional and connectivity correlates associated with Parkinson’s disease psychosis: a systematic review
Pisani, S., Gunasekera, B., Lu, Y., Vignando, M., Ffytche, D., Aarsland, D., Chaudhuri, K. R., Ballard, C., Lee, J. Y., Kim, Y. K., Velayudhan, L. & Bhattacharyya, S., 2024, In: Brain Communications. 6, 6, fcae358.Research output: Contribution to journal › Review article › peer-review
Parkinson’s disease psychosis associated with accelerated multidomain cognitive decline
Pisani, S., Gosse, L., Aarsland, D., Ray Chaudhuri, K., Ballard, C., Ffytche, D., Velayudhan, L. & Bhattacharyya, S., 23 Jul 2024, In: BMJ mental health. 27, 1, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
Visual mismatch negativity in Parkinson’s psychosis and potential for testing treatment mechanisms
Vignando, M., Ffytche, D., Mazibuko, N., Palma, G., Montagnese, M., Dave, S., Nutt, D., Gabay, A., Tai, Y., Batzu, L., Leta, V., Williams Gray, C., Chaudhuri, K. & Mehta, M., 14 May 2024, (Accepted/In press) In: Brain Communications.Research output: Contribution to journal › Article › peer-review
Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion
Guu, T.-W., Brem, A.-K., Albertyn, C. P., Kandangwa, P., Aarsland, D. & Ffytche, D., May 2024, In: Alzheimer's & Dementia. 20, 5, p. 3211-3218 8 p.Research output: Contribution to journal › Article › peer-review
Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion
Guu, T.-W., Brem, A.-K., Albertyn, C., Kandangwa, P., Aarsland, D. & Ffytche, D., 18 Mar 2024, In: Alzheimer's & Dementia.Research output: Contribution to journal › Article › peer-review
Cognitive and executive impairments in Parkinson's disease psychosis: a Bayesian meta-analysis
Pisani, S., Gosse, L., Wieretilo, R., Ffytche, D., Velayudhan, L. & Bhattacharyya, S., 19 Jul 2023, (E-pub ahead of print) In: Journal of neurology, neurosurgery, and psychiatry. jnnp-2022-331028.Research output: Contribution to journal › Review article › peer-review
Grey matter volume loss in Parkinson’s Disease Psychosis and its relationship with serotonergic gene expression: A meta-analysis
Pisani, S., Gunasekera, B., Lu, Y., Vignando, M., Ffytche, D., Aarsland, D., Chaudhuri, K. R., Ballard, C., Lee, J.-Y., Kim, Y. K., Velayudhan, L. & Bhattacharyya, S., Apr 2023, In: Neuroscience and Biobehavioral Reviews. 147, 105081.Research output: Contribution to journal › Review article › peer-review
Neuropathological correlates of neuropsychiatric symptoms in dementia
Gibson, L. L., Grinberg, L. T., ffytche, D., Leite, R. E. P., Rodriguez, R. D., Ferretti-Rebustini, R. E. L., Pasqualucci, C. A., Nitrini, R., Jacob-Filho, W., Aarsland, D. & Suemoto, C. K., Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1372-1382 11 p.Research output: Contribution to journal › Article › peer-review
Wearable devices: underrepresentation in the ageing society
Guu, T. W., Muurling, M., Khan, Z., Kalafatis, C., Aarsland, D., ffytche, D. & Brem, A. K., Jun 2023, In: The Lancet Digital Health. 5, 6, p. e336-e337Research output: Contribution to journal › Comment/debate › peer-review
Wearable devices: underrepresentation in the ageing society
Guu, T.-W., Muurling, M., Khan, Z., Kalafatis, C., Aarsland, D., Ffytche, D. & Brem, A.-K., Jun 2023, In: The Lancet. Digital health. 5, 6, p. e336-e337Research output: Contribution to journal › Article › peer-review
Cognitive and visual processing performance in Parkinson's disease patients with vs without visual hallucinations: A meta-analysis
Montagnese, M., Vignando, M., ffytche, D. & Mehta, M. A., Jan 2022, In: Cortex. 146, p. 161-172 12 p.Research output: Contribution to journal › Article › peer-review
Investigation of structural brain changes in Charles Bonnet Syndrome
Firbank, M. J., daSilva Morgan, K., Collerton, D., Elder, G. J., Parikh, J., Olsen, K., Schumacher, J., ffytche, D. & Taylor, J. P., Jan 2022, In: NeuroImage: Clinical. 35, 103041.Research output: Contribution to journal › Article › peer-review
Light, sleep-wake rhythm, and behavioural and psychological symptoms of dementia in care home patients: Revisiting the sundowning syndrome
Guu, T.-W., Aarsland, D. & Ffytche, D., May 2022, In: International Journal of Geriatric Psychiatry. 37, 5, GPS5712.Research output: Contribution to journal › Review article › peer-review
The medial occipital longitudinal tract supports early stage encoding of visuospatial information
Beyh, A., Dell' Acqua, F., Cancemi, D., De Santiago Requejo, F., Ffytche, D. & Catani, M., Dec 2022, In: Communications Biology. 5, 1, 318.Research output: Contribution to journal › Article › peer-review
Transcranial Direct Current Stimulation in the Treatment of Visual Hallucinations in Charles Bonnet Syndrome: A Randomized Placebo-Controlled Crossover Trial
daSilva Morgan, K., Schumacher, J., Collerton, D., Colloby, S., Elder, G. J., Olsen, K., ffytche, D. H. & Taylor, J. P., Dec 2022, In: Ophthalmology. 129, 12, p. 1368-1379 12 p.Research output: Contribution to journal › Article › peer-review
Visual hallucinations in Lewy body disease: pathophysiological insights from phenomenology
D’Antonio, F., Boccia, M., Di Vita, A., Suppa, A., Fabbrini, A., Canevelli, M., Caramia, F., Fiorelli, M., Guariglia, C., Ferracuti, S., de Lena, C., Aarsland, D. & ffytche, D., Jul 2022, In: Journal of Neurology. 269, 7, p. 3636-3652 17 p.Research output: Contribution to journal › Article › peer-review
A century of prosopometamorphopsia studies
Blom, J. D., Meulen, B. T., Dool, J. & Ffytche, D., 13 Mar 2021, (Accepted/In press) In: Cortex; a journal devoted to the study of the nervous system and behavior.Research output: Contribution to journal › Article › peer-review
Cerebellar Correlates of Visual Hallucinations in Parkinson’s Disease and Charles Bonnet Syndrome
Lawn, T. & Ffytche, D., Feb 2021, In: Cortex. 135, p. 311-325 15 p.Research output: Contribution to journal › Article › peer-review
Cerebellar involvement in hallucinations may transcend clinical conditions and perceptual modalities
Lawn, T. & ffytche, D., Oct 2021, In: Cortex. 143, p. 290-294 5 p.Research output: Contribution to journal › Article › peer-review
Cognition, hallucination severity and hallucination-specific insight in neurodegenerative disorders and eye disease
Montagnese, M., Vignando, M., Collerton, D., Ffytche, D., Mosimann, U. P., Taylor, J.-P., daSilva Morgan, K. & Urwyler, P., 2 Aug 2021, (E-pub ahead of print) In: Cognitive Neuropsychiatry. 17 p.Research output: Contribution to journal › Article › peer-review
Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome
Puledda, F., O'Daly, O., Schankin, C., Ffytche, D., Williams, S. C. & Goadsby, P. J., May 2021, In: Human Brain Mapping. 42, 7, p. 2032-2044 13 p.Research output: Contribution to journal › Article › peer-review
Localised increase in regional cerebral perfusion in patients with visual snow syndrome: A pseudo-continuous arterial spin labelling study
Puledda, F., Schankin, C. J., O'Daly, O., Ffytche, D., Eren, O., Karsan, N., Williams, S. C. R., Zelaya, F. & Goadsby, P. J., 1 Sept 2021, In: Journal of Neurology, Neurosurgery and Psychiatry. 92, 9, p. 918-926 9 p.Research output: Contribution to journal › Article › peer-review
Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations
Vignando, M., Ffytche, D., Lewis, S. J. G., Lee, P. H., Chung, S. J., Weil, R. S., Hu, M., Mackay, C., Griffanti, L., Pins, D., Dujardin, K., Jardri, R., Paul Taylor, J., Firbank, M. J., McAlonan, G., Ka-Fung Mak, H., Ho, S.-L. & Mehta, M., 14 Dec 2021, (Accepted/In press) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson’s disease
Oikonomou, P., van Wamelen, D. J., Weintraub, D., Aarsland, D., Ffytche, D., Martinez-Martin, P., Rodriguez-Blazquez, C., Leta, V., Borley, C., Sportelli, C., Trivedi, D., Podlewska, A. M., Rukavina, K., Rizos, A., Lazcano-Ocampo, C. & Ray Chaudhuri, K., May 2021, In: Brain and Behavior. 11, 5, e02086.Research output: Contribution to journal › Article › peer-review
Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease
Jaramillo-Jimenez, A., Suarez-Revelo, J. X., Ochoa-Gomez, J. F., Carmona Arroyave, J. A., Bocanegra, Y., Lopera, F., Buriticá, O., Pineda-Salazar, D. A., Moreno Gómez, L., Tobón Quintero, C. A., Borda, M. G., Bonanni, L., Ffytche, D. H., Brønnick, K. & Aarsland, D., Mar 2021, In: Clinical Neurophysiology. 132, 3, p. 756-764 9 p.Research output: Contribution to journal › Article › peer-review
The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial
Gilleen, J., Nottage, J., Yakub, F., Kerins, S., Valdearenas, L., Uz, T., Lahu, G., Tsai, M., Ogrinc, F., Williams, S. C., Ffytche, D., Mehta, M. A. & Shergill, S. S., Jan 2021, In: Journal of Psychopharmacology. 35, 1, p. 15-22 8 p.Research output: Contribution to journal › Article › peer-review
A Preliminary Investigation of the Views of People With Parkinson's (With and Without Psychosis) and Caregivers on Participating in Clinical Trials During the Covid-19 Pandemic: An Online Survey
McGoohan, K., Amjad, A., Ratcliffe, N., Bhattacharyya, S., Granville, G., Sullivan, M., Gosden, L., Aarsland, D., Chaudhuri, K. R., Ffytche, D., Ballard, C. & Velayudhan, L., 23 Dec 2020, In: Frontiers in Psychiatry. 11, p. 602480Research output: Contribution to journal › Article › peer-review
A preliminary investigation of the views of people with Parkinson’s disease psychosis and caregivers on participating in clinical trials during the COVID-19 pandemic: an online survey
McGoohan, K., Amjad, A., Ratcliffe, N., Bhattacharyya, S., Granville, G., Sullivan, M., Gosden, L., Aarsland, D., Chaudhuri, K., Ffytche, D., Ballard, C. & Velayudhan, L., 23 Dec 2020, In: Frontiers in Psychiatry.Research output: Contribution to journal › Article › peer-review
Drug and Disease Effects in Parkinson's Psychosis: Revisiting the Role of Dopamine
Dave, S., Weintraub, D., Aarsland, D. & ffytche, D. H., 1 Jan 2020, In: Movement Disorders Clinical Practice. 7, 1, p. 32-36 5 p.Research output: Contribution to journal › Article › peer-review
Hallucinations and other psychotic experiences across diagnoses: A comparison of phenomenological features
Schutte, M. J. L., Linszen, M. M. J., Marschall, T. M., ffytche, D. H., Koops, S., van Dellen, E., Heringa, S. M., Slooter, A. J. C., Teunisse, R., van den Heuvel, O. A., Lemstra, A. W., Foncke, E. M. J., Slotema, C. W., de Jong, J., Rossell, S. L. & Sommer, I. E. C., Oct 2020, In: Psychiatry Research. 292, 113314.Research output: Contribution to journal › Article › peer-review
Hallucinations in Older Adults: A Practical Review
Badcock, J. C., Larøi, F., Kamp, K., Kelsall-Foreman, I., Bucks, R. S., Weinborn, M., Begemann, M., Taylor, J. P., Collerton, D., O'Brien, J. T., El Haj, M., Ffytche, D. & Sommer, I. E., 1 Dec 2020, In: Schizophrenia bulletin. 46, 6, p. 1382-1395 14 p.Research output: Contribution to journal › Article › peer-review
Insular and occipital changes in visual snow syndrome: a BOLD fMRI and MRS study
Puledda, F., Ffytche, D., Lythgoe, D. J., O'Daly, O., Schankin, C., Williams, S. C. R. & Goadsby, P. J., 10 Mar 2020, (E-pub ahead of print) In: Annals of Clinical and Translational Neurology. 7, 3, p. 296-306 11 p.Research output: Contribution to journal › Article › peer-review
Occipital cortex and cerebellum gray matter changes in visual snow syndrome
Puledda, F., Bruchhage, M., O'Daly, O., Ffytche, D., Williams, S. C. R. & Goadsby, P. J., 29 Sept 2020, In: Neurology. 95, 13, p. e1792-e1799Research output: Contribution to journal › Article › peer-review
Resting-state qEEG Alpha/Theta ratio related to neuropsychological test performance in Parkinson’s Disease
Aarsland, D., Ffytche, D. & Jaramillo-Jimenez, A., 18 Nov 2020, (Accepted/In press) In: Clinical Neurophysiology.Research output: Contribution to journal › Article › peer-review
Visual hallucinations in neurological and ophthalmological disease: Pathophysiology and management
O'Brien, J., Taylor, J. P., Ballard, C., Barker, R. A., Bradley, C., Burns, A., Collerton, D., Dave, S., Dudley, R., Francis, P., Gibbons, A., Harris, K., Lawrence, V., Leroi, I., McKeith, I., Michaelides, M., Naik, C., O'Callaghan, C., Olsen, K. & Onofrj, M. & 7 others, Pinto, R., Russell, G., Swann, P., Thomas, A., Urwyler, P., Weil, R. S. & Ffytche, D., 1 May 2020, In: Journal of Neurology, Neurosurgery and Psychiatry. 91, 5, p. 512-519 8 p., 322702.Research output: Contribution to journal › Review article › peer-review
Drug and disease effects in Parkinson’s psychosis: revisiting the role of dopamine
Dave, S., Weintraub, D., Aarsland, D. & Ffytche, D. H., 14 Sept 2019, (Accepted/In press) In: Movement Disorders Clinical Practice.Research output: Contribution to journal › Article › peer-review
Imaging the Visual Network in the Migraine Spectrum
Puledda, F., Ffytche, D., O'Daly, O. & Goadsby, P. J., 13 Dec 2019, In: Frontiers in Neurology. 10, p. 1325 1325.Research output: Contribution to journal › Review article › peer-review
Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management.. Journal of neurology, neurosurgery, and psychiatry
O'Brien, J., Taylor, J. P., Ballard, C., Barker, C., Bradley, C., Burns, A., Collerton, D., Dave, S., Dudley, R., Francis, P., Gibbons, A., Harris, K., Lawrence, V., Leroi, I., McKeith, I., Michaelides, M., Olson, K., Naik, C., O'Callaghan, C. & Onofri, M. & 6 others, Pinto, R., Russell, G., Swann, P., Urwyler, P., Weil, R. & Ffytche, D., 1 Jan 2019, In: Journal of Neurology, Neurosurgery and Psychiatry. 91, 5Research output: Contribution to journal › Article › peer-review
Amyloid-β and Parkinson’s disease
Lim, E. W., Aarsland, D., Ffytche, D., Taddei, R. N., van Wamelen, D. J., Wan, Y. M., Tan, E. K., Ray Chaudhuri, K. & Kings Parcog groupMDS Nonmotor study group, 19 Oct 2018, (Accepted/In press) In: Journal of Neurology.Research output: Contribution to journal › Article › peer-review
Assessment and Management of Neuropsychiatric Symptoms in Parkinson's Disease
Mueller, C., Rajkumar, A. P., Wan, Y. M., Velayudhan, L., ffytche, D., Chaudhuri, K. R. & Aarsland, D., Jul 2018, In: CNS Drugs. 32, 7, p. 621-635 15 p.Research output: Contribution to journal › Article › peer-review
Successful management of persistent distressing neuropsychiatric symptoms by clozapine in a patient suffering from dementia with Lewy bodies
Bhamra, M., Rajkumar, A. P., Ffytche, D. H. & Kalafatis, C., 26 Jul 2018, In: BMJ case reports. 2018Research output: Contribution to journal › Article › peer-review
The utility and application of electrophysiological methods in the study of visual hallucinations
daSilva Morgan, K., Elder, G. J., ffytche, D. H., Collerton, D. & Taylor, J.-P., 6 Sept 2018, (E-pub ahead of print) In: Clinical Neurophysiology. 129, 11, p. 2361-2371Research output: Contribution to journal › Review article › peer-review
Visual Hallucinations in Dementia and Parkinson’s Disease: A Qualitative Exploration of Patient and Caregiver Experiences
Renouf, S., ffytche, D., Pinto, R., Murray, J. & Lawrence, V., Oct 2018, In: International Journal of Geriatric Psychiatry. 33, 10, p. 1327-1334 8 p.Research output: Contribution to journal › Article › peer-review
Accuracy of Clinical Diagnosis of Dementia with Lewy Bodies versus Neuropathology
Skogseth, R. E., Hortobágyi, T., Soennesyn, H., Chwiszczuk, L., Ffytche, D., Rongve, A., Ballard, C. & Aarsland, D., 14 Aug 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 59, 4, p. 1139-1152 14 p.Research output: Contribution to journal › Article › peer-review
Cognitive decline in Parkinson disease
Aarsland, D., Creese, B., Politis, M., Ray Chaudhuri, K., Ffytche, D. H., Weintraub, D. & Ballard, C., Apr 2017, In: Nature Reviews Neurology. 13, p. 217–231Research output: Contribution to journal › Article › peer-review
New Therapeutic Strategies for Lewy Body Dementias
Velayudhan, L., Ffytche, D., Ballard, C. & Aarsland, D., Sept 2017, In: CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. 17, 9, p. 68Research output: Contribution to journal › Review article › peer-review
Research

Cannabidiol for Parkinson’s Disease Psychosis (CAN-PDP) Trial
Multi-centre trial of cannabidiol (CBD) for the treatment of Parkinson's disease psychosis
Project status: Ongoing

Centre for Healthy Brain Ageing
The centre supports the development of biomarkers in neurocognitive disorders, and novel strategies to support the early diagnosis of AD and related disorders.
News
Visual mismatch negativity identified as a mechanism of Parkinson's disease psychosis
Reduced brain activity responding to unpredicted visual changes is a marker of psychosis in Parkinson’s disease and a potential therapeutic target
