Professor Christopher Shaw MD, FRACP, FRCP (Hon), FMedSci, FANA, FK
Professor of Neurology and Neurogenetics
Research interests
- Neuroscience
Contact details
Biography
I am a Professor of Neurology & Neurogenetics at the IoPPN and Director of The Maurice Wohl Clinical Neuroscience Institute. I am a Group Leader at UK DRI at King's and the former Director (2017-2022). My research group focuses on frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with two main objectives:
- To develop novel AAV-based gene therapy therapeutic approaches. Optimising AAV9 vectors for gene delivery into the CNS from preclinical experiments in cells and rodents up to first-in-human experimental medicine studies.
- To map TDP-43 proteostasis in vitro using human iPSc-derived neurons: phenotypic analyses including transcriptomics, proteomics and high-content imaging in cultured motor neurons – including patient-derived iPSC and isogenic lines generated by genome editing with CRISPR/Cas9.
Please see my Research Staff Profile for more detail.
Key Publications:
- Gkazi et al., 2019. Striking phenotypic variation in a family with the P506S UBQLN2 mutation including amyotrophic lateral sclerosis, spastic paraplegia, and frontotemporal dementia. Neurobiol Aging.
- Selvarajet al., 2018. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nat Commun.
- de Majo et al, 2018. ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function. Neurobiol Aging.
- Smith et al., 2017. Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Science Translational Medicine.
- Lee et al, 2017. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity. Hum Mol Genet.
Key Collaborators:
- Professor Ammar Al-Chalabi, King's College London
- Dr Robert H Brown Jr, University of Massachusetts
- Professor John Landers, University of Massachusetts
- Professor Siddarthan Chandran, University of Edinburgh
News
AviadoBio and Astella announce exclusive option and license agreement for gene therapy AVB-101 targeting frontotemporal dementia
The agreement leverages King’s College London spin-out company’s expertise in developing targeted gene therapy for neurodegenerative diseases
Demystifying Impact 2024
IoPPN researchers and NHS Trusts staff discussed the effect and importance of partnerships and collaborations at this year's annual Demystifying Impact event...
King's spinout to develop ground-breaking neurodegenerative gene therapy
AviadoBio is an exciting new spin-out company founded by King’s College London researchers Professor Christopher Shaw, Dr Youn Bok Lee and Dr Do Young Lee
News
AviadoBio and Astella announce exclusive option and license agreement for gene therapy AVB-101 targeting frontotemporal dementia
The agreement leverages King’s College London spin-out company’s expertise in developing targeted gene therapy for neurodegenerative diseases
Demystifying Impact 2024
IoPPN researchers and NHS Trusts staff discussed the effect and importance of partnerships and collaborations at this year's annual Demystifying Impact event...
King's spinout to develop ground-breaking neurodegenerative gene therapy
AviadoBio is an exciting new spin-out company founded by King’s College London researchers Professor Christopher Shaw, Dr Youn Bok Lee and Dr Do Young Lee