Skip to main content
Christopher Shaw

Professor Christopher Shaw MD, FRACP, FRCP (Hon), FMedSci, FANA, FK

Professor of Neurology and Neurogenetics

Research interests

  • Neuroscience

Contact details

Biography

I am a Professor of Neurology & Neurogenetics at the IoPPN and Director of The Maurice Wohl Clinical Neuroscience Institute. I am a Group Leader at UK DRI at King's and the former Director (2017-2022). My research group focuses on frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with two main objectives:

  1. To develop novel AAV-based gene therapy therapeutic approaches. Optimising AAV9 vectors for gene delivery into the CNS from preclinical experiments in cells and rodents up to first-in-human experimental medicine studies.
  2. To map TDP-43 proteostasis in vitro using human iPSc-derived neurons: phenotypic analyses including transcriptomics, proteomics and high-content imaging in cultured motor neurons – including patient-derived iPSC and isogenic lines generated by genome editing with CRISPR/Cas9.

Please see my Research Staff Profile  for more detail.

Key Collaborators:

  • Professor Ammar Al-Chalabi, King's College London
  • Dr Robert H Brown Jr, University of Massachusetts
  • Professor John Landers, University of Massachusetts
  • Professor Siddarthan Chandran, University of Edinburgh

News

AviadoBio and Astella announce exclusive option and license agreement for gene therapy AVB-101 targeting frontotemporal dementia

The agreement leverages King’s College London spin-out company’s expertise in developing targeted gene therapy for neurodegenerative diseases

Brain Web

Demystifying Impact 2024

IoPPN researchers and NHS Trusts staff discussed the effect and importance of partnerships and collaborations at this year's annual Demystifying Impact event...

Demystifying Impact 6

King's spinout to develop ground-breaking neurodegenerative gene therapy

AviadoBio is an exciting new spin-out company founded by King’s College London researchers Professor Christopher Shaw, Dr Youn Bok Lee and Dr Do Young Lee

Chris Shaw brain

News

AviadoBio and Astella announce exclusive option and license agreement for gene therapy AVB-101 targeting frontotemporal dementia

The agreement leverages King’s College London spin-out company’s expertise in developing targeted gene therapy for neurodegenerative diseases

Brain Web

Demystifying Impact 2024

IoPPN researchers and NHS Trusts staff discussed the effect and importance of partnerships and collaborations at this year's annual Demystifying Impact event...

Demystifying Impact 6

King's spinout to develop ground-breaking neurodegenerative gene therapy

AviadoBio is an exciting new spin-out company founded by King’s College London researchers Professor Christopher Shaw, Dr Youn Bok Lee and Dr Do Young Lee

Chris Shaw brain