Benoit has worked with Professor Sasieni at Cancer Research UK since 2002, when he participated in the set-up of the International Breast cancer Intervention Study II (IBIS-II), a large multi-centre phase III trial investigating chemoprevention. Benoit became Head of Operations for the Cancer Prevention Trials Unit (CPTU) at Queen Mary University of London in 2006, when Professors Cuzick and Sasieni received the first Cancer Research UK Programme grant to set-up a unit specialising in cancer prevention and screening. Since July 2019, Benoit has been supporting the CPTU in a Clinical Project Management Consultant role, focusing on strategic planning of cross-functional teams, facilities, and services to ensure that the evolving needs of the researchers and regulatory requirements are continually met. In particular, Benoit provides support to the CPTU team and investigators to facilitate the development of high-quality clinical trials by supporting new funding applications, advising on trial operations, resource requirements, preparing costing, reviewing and negotiating new contracts.