
Professor Ben Forbes
Professor of Pharmaceutics
- Joint Head of School, School of Cancer & Pharmaceutical Sciences and Head of Institute of Pharmaceutical Science
Research interests
- Pharmacy
Biography
Ben Forbes is Professor of Pharmaceutics at King’s College London. He has a BPharm from King’s College London (1987) and a PhD in Drug Delivery from Strathclyde University (1996). Before doctoral studies, he worked in hospital pharmacy in London and Sydney, and for Inveresk Clinical Research in Edinburgh. He was appointed to the academic staff of King’s College London in 1997 and is a registered pharmacist in the UK. The term ‘Inhalation Biopharmaceutics’ was coined by Ben Forbes in the dying embers of the last Millennium to describe the scientific field that considers the factors that influence respiratory and systemic exposure to inhaled drugs [Ehrhardt C, Pharm Res 34: 2451–2453, 2017], and he has authored many publications in this area, including:
• inhaled medicine formulation,
• the development and application of techniques to study respiratory drug transport and metabolism,
• inhalation toxicology.
He chairs the Scientific Advisory Committee of the Aerosol Society’s annual Drug Delivery to the Lung’s (DDL) conference.
Targeted nasal delivery of LNP-mRNAs aerosolised by Rayleigh breakup technology
Li, H.-Y., Paramanandana, A., Kim, S. Y., Granger, L., Raimi-Abraham, B. T., Shattock, R., Makatsoris, C. & Forbes, B., 15 Mar 2025, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 672, p. 125335 125335.Research output: Contribution to journal › Article › peer-review
Intratracheal Administration of Nanoplastics With Varying Surface Hydrophobicity Results in Coarsely Vacuolated Alveolar Macrophages, Transient Respiratory Inflammation, and Mild Collagen Deposition
Babin, A., Riffo Vasquez, Y., Bodhaniya, A., Jones, S., Forbes, B., Sunassee, K., T. M. de Rosales, R., Wright, S., Page, C. & Dailey, L. A., 14 Jan 2025, (Accepted/In press) In: Nano Select. e202400154.Research output: Contribution to journal › Article › peer-review
PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies
Victor, S., Forbes, B., Greenough, A. & Edwards, D., 27 Oct 2023, In: Pharmaceuticals. 16, 11, p. 1530 11 p., 1530.Research output: Contribution to journal › Review article › peer-review
Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model
Carserides, C., Smith, K., Zinicola, M., Kumar, A., Swedrowska, M., Scala, C., Cameron, G., Riches, Z., Iannelli, F., Pozzi, G., Hold, G. L., Forbes, B., Kelly, C. & Hijazi, K., Sept 2022, In: Pharmaceutics. 14, 9, 1938.Research output: Contribution to journal › Article › peer-review
Design and manufacture of a lyophilised faecal microbiota capsule formulation to GMP standards
Zain, N. M. M., ter Linden, D., Lilley, A. K., Royall, P. G., Tsoka, S., Bruce, K. D., Mason, A. J., Hatton, G. B., Allen, E., Goldenberg, S. D. & Forbes, B., Oct 2022, In: Journal of Controlled Release. 350, p. 324-331 8 p.Research output: Contribution to journal › Article › peer-review
The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery
Wingrove, J., O'Daly, O., De Lara Rubio, A., Hill, S., Swedroska, M., Forbes, B., Amiel, S. & Zelaya, F., 15 Dec 2022, In: Human Brain Mapping. 43, 18, p. 5432-5451 20 p.Research output: Contribution to journal › Article › peer-review
Exploiting Endocytosis for Non-Spherical Nanoparticle Cellular Uptake
Niaz, S., Forbes, B. & Raimi-Abraham, B. T., 1 Feb 2022, (E-pub ahead of print) In: Nanomanufacturing. 2, 1, p. 1-16 16 p.Research output: Contribution to journal › Review article › peer-review
Respicelltm: An innovative dissolution apparatus for inhaled products
Sonvico, F., Chierici, V., Varacca, G., Quarta, E., D’angelo, D., Forbes, B. & Buttini, F., Oct 2021, In: Pharmaceutics. 13, 10, 1541.Research output: Contribution to journal › Article › peer-review
In vitro Fourier transform infrared spectroscopic study of the effect of glycerol on the uptake of beclomethasone dipropionate in living respiratory cells
Terakosolphan, W., Altharawi, A., Poonprasartporn, A., Harvey, R. D., Forbes, B. & Chan, K. L. A., 20 Nov 2021, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 609, 121118.Research output: Contribution to journal › Article › peer-review
Improving drug delivery for alzheimer’s disease through nose-to-brain delivery using nanoemulsions, nanostructured lipid carriers (NLC) and in situ hydrogels
Cunha, S., Forbes, B., Lobo, J. M. S. & Silva, A. C., 2021, In: International Journal of Nanomedicine. 16, p. 4373-4390 18 p.Research output: Contribution to journal › Review article › peer-review
Fluticasone Particles Bind to Motile Respiratory Cilia: A Mechanism for Enhanced Lung and Systemic Exposure?
Lee, D. D. H., Cardinale, D., Terakosolphan, W., Sornsute, A., Radhakrishnan, P., Coppel, J., Smith, C. M., Satyanarayana, S., Forbes, B. & O'Callaghan, C., 1 Jun 2021, In: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 34, 3, p. 181-188 8 p.Research output: Contribution to journal › Article › peer-review
Drug metabolism in the lungs: opportunities for optimising inhaled medicines
Enlo-Scott, Z., Bäckström, E., Mudway, I. & Forbes, B., 21 Apr 2021, In: Expert Opinion On Drug Metabolism & Toxicology. 17, 5, p. 611-625 15 p.Research output: Contribution to journal › Review article › peer-review
Epithelial permeability and drug absorption in the lungs
Enlo-Scott, Z., Swedrowska, M. & Forbes, B., 5 Feb 2021, Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches. Academic Press, p. 267-299Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Dissolution: A critical performance characteristic of inhaled products?
Forbes, B., Richer, N. H. & Buttini, F., 1 Jan 2015, Pulmonary Drug Delivery: Advances and Challenges. WILEY-BLACKWELL, p. 223-240 18 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Recommendations for crushing Circadin® (melatonin) tablets for safe and reliable delivery via pediatric nasogastric tubes
Swedrowska, M., Ingham, S., Tomlin, S. & Forbes, B., 1 Feb 2021, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 594, 120151.Research output: Contribution to journal › Article › peer-review
Intranasal insulin administration decreases cerebral blood flow in cortico-limbic regions: A neuropharmacological imaging study in normal and overweight males
Wingrove, J. O., O'Daly, O., Forbes, B., Swedrowska, M., Amiel, S. A. & Zelaya, F. O., Jan 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 175-185 11 p.Research output: Contribution to journal › Article › peer-review
A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency
Jones, S., Sofian, Z. M., Forbes, B., Al-Jamal, K., Benaouda, F., Royall, P., Wang, J., Luo, Y. M., Farag, D. & Rahman, M., 25 Sept 2020, (E-pub ahead of print) In: Advanced Therapeutics.Research output: Contribution to journal › Article › peer-review
An in vitro bioassay for evaluating the effect of inhaled bronchodilators on airway smooth muscle
Muddle, J., Kanabar, V., Brown, M., Page, C. & Forbes, B., Aug 2020, In: Pulmonary Pharmacology and Therapeutics. 63, 101943.Research output: Contribution to journal › Article › peer-review
In vitro and in vivo antitubercular activity of benzothiazinone-loaded human serum albumin nanocarriers designed for inhalation
Forbes, B., Dec 2020, In: JOURNAL OF CONTROLLED RELEASE.Research output: Contribution to journal › Article › peer-review
Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: Formulation variables and instrumental parameters
Cunha, S., Costa, C. P., Loureiro, J. A., Alves, J., Peixoto, A. F., Forbes, B., Lobo, J. M. S. & Silva, A. C., Jul 2020, In: Pharmaceutics. 12, 7, p. 1-27 27 p., 599.Research output: Contribution to journal › Article › peer-review
Pulmonary Administration: Strengthening the Value of Therapeutic Proximity
Videira, M. A., Llop, J., Sousa, C., Kreutzer, B., Cossío, U., Forbes, B., Vieira, I., Gil, N. & Silva-Lima, B., 27 Feb 2020, In: Frontiers in Medicine. 7, 50.Research output: Contribution to journal › Review article › peer-review
CYCLODEXTRIN-STABILISED ION-PAIR COMPLEXES ENHANCE DRUG LUNG UPTAKE VIA THE POLYAMINE TRANSPORTER
Sofian, Z. M., Wang, J. T. W., Yuan, L., Royall, P., Forbes, B., Barlow, D. J., Page, C., Al-Jamal, K. T., Jones, S. & Benaouda, F., 1 Apr 2019, In: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32, 2, p. A11-A11Research output: Contribution to journal › Meeting Abstract › peer-review
Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages
Selley, L., Schuster, L., Marbach, H., Forsthuber, T., Forbes, B., Gant, T. W., Sandström, T., Camiña, N., Athersuch, T. J., Mudway, I. & Kumar, A., 25 Mar 2020, In: Metallomics : integrated biometal science. 12, 3, p. 371-386 16 p.Research output: Contribution to journal › Article › peer-review
Solid-state epimerisation and disproportionation of pilocarpine HCl: Why we need a 5-stage approach to validate melting point measurements for heat-sensitive drugs
Malallah, O. S., Hammond, B., Al-adhami, T., Buanz, A., Alqurshi, A., Carswell, W. D., Rahman, K. M., Forbes, B. & Royall, P. G., 25 Jan 2020, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 574, p. 1-13 118869.Research output: Contribution to journal › Article › peer-review
A consensus research agenda for optimising nasal drug delivery
Forbes, B., Bommer, R., Goole, J., Hellfritzsch, M., De Kruijf, W., Lambert, P., Caivano, G., Regard, A., Schiaretti, F., Trenkel, M., Vecellio, L., Williams, G., Sonvico, F. & Scherlieβ, R., 1 Jan 2020, In: Expert Opinion On Drug Delivery. 17, 2, p. 127-132 6 p.Research output: Contribution to journal › Article › peer-review
Development of new in vitro models of lung protease activity for investigating stability of inhaled biological therapies and drug delivery systems
Woods, A., Andrian, T., Sharp, G., Bicer, E. M., Vandera, K.-K. A., Patel, A., Mudway, I., Dailey, L. A. & Forbes, B., 1 Jan 2020, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 146, p. 64 - 72 9 p.Research output: Contribution to journal › Article › peer-review
Workshop report: USP workshop on exploring the science of drug absorption
Martinez, M. N., Bhoopathy, S., Carlert, S., Cirit, M., Fahmy, R., Flanagan, T., Forbes, B., Jamei, M., Khan, M. A., Lukacova, V., Mochel, J. P., Pepin, X., Pade, D., Reppas, C., Sinko, P. J., Sperry, D., Tsinman, K. & Vertzoni, M., 1 Aug 2019, In: Dissolution Technologies. 26, 3, p. 38-66 29 p.Research output: Contribution to journal › Article › peer-review
Mucus penetrating properties of soft, distensible lipid nanocapsules
Chen, H., Mansfield, E. D. H., Woods, A., Khutoryanskiy, V. V., Forbes, B. & Jones, S. A., Jun 2019, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 139, p. 76-84 9 p.Research output: Contribution to journal › Article › peer-review
Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging
Wingrove, J. O., Swedrowska, M., Scherliss, R., Parry, M., Ramjeeawon, M., Taylor, D. M., Gauthier, G., Brown, L., Amiel, S. A., Zelaya, F. O. & Forbes, B. J., 28 May 2019, In: JOURNAL OF CONTROLLED RELEASE. 302, p. 140-147 7 p.Research output: Contribution to journal › Article › peer-review
Use of PBPK Modeling to Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products
Hassoun, M., Malmlof, M., Scheibelhofer, O., Kumar, A., Bansal, S., Selg, E., Nowenwik, M., Gerde, P., Radivojev, S., Paudel, A., Arora, S. & Forbes, B., 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1245-1254 10 p.Research output: Contribution to journal › Article › peer-review
A novel method for studying airway hyperresponsiveness in allergic Guinea pigs in vivo using the preciseinhale system for delivery of dry powder aerosols
Lexmond, A. J., Keir, S., Terakosolphan, W., Page, C. P. & Forbes, B., 21 Feb 2018, In: Drug Delivery and Translational Research. 8, 3, p. 760-769 10 p.Research output: Contribution to journal › Article › peer-review
Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs
Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B. & van den Berge, M., 1 Apr 2018, In: Pulmonary Pharmacology and Therapeutics. 49, p. 27-35 9 p.Research output: Contribution to journal › Review article › peer-review
Design and development of a biorelevant simulated human lung fluid
Hassoun, M., Royall, P. G., Harvey, R. D. & Forbes, B., Oct 2018, In: Journal of drug delivery science and technology . 47, p. 485-491Research output: Contribution to journal › Article › peer-review
Glycerol solvates DPPC headgroups and localises in the interfacial regions of model pulmonary interfaces altering bilayer structure
Terakosolphan, W., Trick, J. L., Royall, P. G., Rogers, S. E., Lamberti, O., Lorenz, C. D., Forbes, B. & Harvey, R. D., 8 May 2018, (E-pub ahead of print) In: LANGMUIR.Research output: Contribution to journal › Article › peer-review
Freeze-dried formulations: A new perspective on reformulating naloxone
Courtney, P., Alqurshi, A., Forbes, B., Royall, P. G. & Strang, J., 1 Jun 2017, European Pharmaceutical Review, 22, 3, p. 32-36 5 p.Research output: Contribution to specialist publication › Article
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Carhart-Harris, R. L., Bolstridge, M., Day, C. M. J., Rucker, J., Watts, R., Erritzoe, D. E., Kaelen, M., Giribaldi, B., Bloomfield, M., Pilling, S., Rickard, J. A., Forbes, B., Feilding, A., Taylor, D., Curran, H. V. & Nutt, D. J., Feb 2018, In: Psychopharmacology. 29, 3, p. 399–408 10 p.Research output: Contribution to journal › Article › peer-review
Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth)
Malallah, O. S., Garcia, C. M. A., Proctor, G. B., Forbes, B. & Royall, P. G., 6 Feb 2018, (E-pub ahead of print) In: INTERNATIONAL JOURNAL OF PHARMACEUTICS.Research output: Contribution to journal › Article › peer-review
Ion-Pairing with Spermine Targets Theophylline to the Lungs via the Polyamine Transport System
Benaouda, F., Jones, S. A., Chana, J., Dal Corno, B. M., Barlow, D. J., Hider, R. C., Page, C. P. & Forbes, B., 5 Mar 2018, In: Molecular Pharmaceutics. 15, 3, p. 861-870 10 p.Research output: Contribution to journal › Article › peer-review
Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs
Bäckman, P., Arora, S., Couet, W., Forbes, B., de Kruijf, W. & Paudel, A., 25 Oct 2017, (E-pub ahead of print) In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES.Research output: Contribution to journal › Article › peer-review
A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture
Bosquillon, C., Madlova, M., Patel, N., Clear, N. & Forbes, B., 18 Sept 2017, (E-pub ahead of print) In: Pharmaceutical Research. p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
In Silico and in Vitro Screening for P-Glycoprotein Interaction with Tenofovir, Darunavir, and Dapivirine: An Antiretroviral Drug Combination for Topical Prevention of Colorectal HIV Transmission
Swedrowska, M., Jamshidi, S., Kumar, A., Kelly, C., Rahman, K. M. & Forbes, B., 7 Aug 2017, In: Molecular Pharmaceutics. 14, 8, p. 2660-2669 10 p.Research output: Contribution to journal › Article › peer-review
Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
Kumar, A., Bicer, E. M., Pfeffer, P., Monopoli, M. P., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M., Behndig, A. F., Blomberg, A., Somers, G., Hassall, D., Dailey, L. A., Forbes, B. & Mudway, I., 22 Jun 2017, (E-pub ahead of print) In: Nanomedicine-Nanotechnology Biology And Medicine. 13, 8, p. 2517-2521Research output: Contribution to journal › Article › peer-review
A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition
Kumar, A., Terakosolphan, W., Hassoun, M., Vandera, K.-K., Novicky, A., Harvey, R., Royall, P. G., Bicer, E. M., Eriksson, J., Edwards, K., Valkenborg, D., Nelissen, I., Hassall, D., Mudway, I. & Forbes, B., 30 May 2017, (E-pub ahead of print) In: Pharmaceutical Research. p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Drug Delivery Devices for Inhaled Medicines
Lexmond, A. & Forbes, B., 4 Nov 2016, Handbook of Experimental Pharmacology. Springer New York LLC, Vol. 237. p. 265-280 16 p. (Handbook of Experimental Pharmacology; vol. 237).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs
Ehrhardt, C., Bäckman, P., Couet, W., Edwards, C., Forbes, B., Fridén, M., Gumbleton, M., Hosoya, K.-I., Kato, Y., Nakanishi, T., Takano, M., Terasaki, T. & Yumoto, R., 15 Apr 2017, (E-pub ahead of print) In: Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › peer-review
Mixed micelles of lipoic acid-chitosan-poly(ethylene glycol) and distearoylphosphatidylethanolamine-poly(ethylene glycol) for tumor delivery
Elsaid, Z., Taylor, K. M. G., Puri, S., Eberlein, C. A., Al-Jamal, K., Bai, J., Klippstein, R., Wang, J. T. W., Forbes, B., Chana, J. & Somavarapu, S., 1 Apr 2017, In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 101, p. 228-242 15 p.Research output: Contribution to journal › Article › peer-review
Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery
Martinelli, F., Balducci, A. G., Kumar, A., Sonvico, F., Forbes, B., Bettini, R. & Buttini, F., 30 Jan 2017, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 517, 1-2, p. 286-295 10 p.Research output: Contribution to journal › Article › peer-review
Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks
Muddle, J., Kirton, S. B., Parisini, I., Muddle, A., Murnane, D., Ali, J., Brown, M., Page, C. & Forbes, B., Jan 2017, In: Journal of Pharmaceutical Sciences. 106, 1, p. 313–321Research output: Contribution to journal › Article › peer-review
Current practice of preparing morphine infusions for nurse/patient-controlled analgesia in a UK paediatric hospital: healthcare professionals’ views and experiences
Rashed, A. N., Tomlin, S., Forbes, B. J. & Whittlesea, C. M. C., 2018, In: European journal of hospital pharmacy-Science and practice. 25, p. 327-330Research output: Contribution to journal › Article › peer-review
The influence of electrostatic properties on the punch sticking propensity of pharmaceutical blends
Samiei, L., Kelly, K., Taylor, L., Forbes, B., Collins, E. & Rowland, M., 1 Jan 2017, In: POWDER TECHNOLOGY. 305, p. 509-517 9 p.Research output: Contribution to journal › Article › peer-review
Research

Medicines Development
The Medicines Development Research Group develops novel materials, formulations, drug delivery devices, manufacturing, analytical, and digital technologies.

Antimicrobial Research Theme
Antimicrobial Research Theme
News
King's engineer leading research project on rapid vaccine manufacture
WellcomeLEAP grant for rapid vaccine manufacture

KC Wong Postdoctoral Fellowships now open
The School of Cancer & Pharmaceutical Sciences are pleased to open applications for KC Wong Fellowships.

Six new Studentships for Institute of Pharmaceutical Science
The School of Cancer & Pharmaceutical Science are pleased to announce that there are six new studentships within the Institute of Pharmaceutical Sciences.

Targeted nasal delivery of LNP-mRNAs aerosolised by Rayleigh breakup technology
Li, H.-Y., Paramanandana, A., Kim, S. Y., Granger, L., Raimi-Abraham, B. T., Shattock, R., Makatsoris, C. & Forbes, B., 15 Mar 2025, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 672, p. 125335 125335.Research output: Contribution to journal › Article › peer-review
Intratracheal Administration of Nanoplastics With Varying Surface Hydrophobicity Results in Coarsely Vacuolated Alveolar Macrophages, Transient Respiratory Inflammation, and Mild Collagen Deposition
Babin, A., Riffo Vasquez, Y., Bodhaniya, A., Jones, S., Forbes, B., Sunassee, K., T. M. de Rosales, R., Wright, S., Page, C. & Dailey, L. A., 14 Jan 2025, (Accepted/In press) In: Nano Select. e202400154.Research output: Contribution to journal › Article › peer-review
PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies
Victor, S., Forbes, B., Greenough, A. & Edwards, D., 27 Oct 2023, In: Pharmaceuticals. 16, 11, p. 1530 11 p., 1530.Research output: Contribution to journal › Review article › peer-review
Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model
Carserides, C., Smith, K., Zinicola, M., Kumar, A., Swedrowska, M., Scala, C., Cameron, G., Riches, Z., Iannelli, F., Pozzi, G., Hold, G. L., Forbes, B., Kelly, C. & Hijazi, K., Sept 2022, In: Pharmaceutics. 14, 9, 1938.Research output: Contribution to journal › Article › peer-review
Design and manufacture of a lyophilised faecal microbiota capsule formulation to GMP standards
Zain, N. M. M., ter Linden, D., Lilley, A. K., Royall, P. G., Tsoka, S., Bruce, K. D., Mason, A. J., Hatton, G. B., Allen, E., Goldenberg, S. D. & Forbes, B., Oct 2022, In: Journal of Controlled Release. 350, p. 324-331 8 p.Research output: Contribution to journal › Article › peer-review
The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery
Wingrove, J., O'Daly, O., De Lara Rubio, A., Hill, S., Swedroska, M., Forbes, B., Amiel, S. & Zelaya, F., 15 Dec 2022, In: Human Brain Mapping. 43, 18, p. 5432-5451 20 p.Research output: Contribution to journal › Article › peer-review
Exploiting Endocytosis for Non-Spherical Nanoparticle Cellular Uptake
Niaz, S., Forbes, B. & Raimi-Abraham, B. T., 1 Feb 2022, (E-pub ahead of print) In: Nanomanufacturing. 2, 1, p. 1-16 16 p.Research output: Contribution to journal › Review article › peer-review
Respicelltm: An innovative dissolution apparatus for inhaled products
Sonvico, F., Chierici, V., Varacca, G., Quarta, E., D’angelo, D., Forbes, B. & Buttini, F., Oct 2021, In: Pharmaceutics. 13, 10, 1541.Research output: Contribution to journal › Article › peer-review
In vitro Fourier transform infrared spectroscopic study of the effect of glycerol on the uptake of beclomethasone dipropionate in living respiratory cells
Terakosolphan, W., Altharawi, A., Poonprasartporn, A., Harvey, R. D., Forbes, B. & Chan, K. L. A., 20 Nov 2021, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 609, 121118.Research output: Contribution to journal › Article › peer-review
Improving drug delivery for alzheimer’s disease through nose-to-brain delivery using nanoemulsions, nanostructured lipid carriers (NLC) and in situ hydrogels
Cunha, S., Forbes, B., Lobo, J. M. S. & Silva, A. C., 2021, In: International Journal of Nanomedicine. 16, p. 4373-4390 18 p.Research output: Contribution to journal › Review article › peer-review
Fluticasone Particles Bind to Motile Respiratory Cilia: A Mechanism for Enhanced Lung and Systemic Exposure?
Lee, D. D. H., Cardinale, D., Terakosolphan, W., Sornsute, A., Radhakrishnan, P., Coppel, J., Smith, C. M., Satyanarayana, S., Forbes, B. & O'Callaghan, C., 1 Jun 2021, In: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 34, 3, p. 181-188 8 p.Research output: Contribution to journal › Article › peer-review
Drug metabolism in the lungs: opportunities for optimising inhaled medicines
Enlo-Scott, Z., Bäckström, E., Mudway, I. & Forbes, B., 21 Apr 2021, In: Expert Opinion On Drug Metabolism & Toxicology. 17, 5, p. 611-625 15 p.Research output: Contribution to journal › Review article › peer-review
Epithelial permeability and drug absorption in the lungs
Enlo-Scott, Z., Swedrowska, M. & Forbes, B., 5 Feb 2021, Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches. Academic Press, p. 267-299Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Dissolution: A critical performance characteristic of inhaled products?
Forbes, B., Richer, N. H. & Buttini, F., 1 Jan 2015, Pulmonary Drug Delivery: Advances and Challenges. WILEY-BLACKWELL, p. 223-240 18 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Recommendations for crushing Circadin® (melatonin) tablets for safe and reliable delivery via pediatric nasogastric tubes
Swedrowska, M., Ingham, S., Tomlin, S. & Forbes, B., 1 Feb 2021, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 594, 120151.Research output: Contribution to journal › Article › peer-review
Intranasal insulin administration decreases cerebral blood flow in cortico-limbic regions: A neuropharmacological imaging study in normal and overweight males
Wingrove, J. O., O'Daly, O., Forbes, B., Swedrowska, M., Amiel, S. A. & Zelaya, F. O., Jan 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 175-185 11 p.Research output: Contribution to journal › Article › peer-review
A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency
Jones, S., Sofian, Z. M., Forbes, B., Al-Jamal, K., Benaouda, F., Royall, P., Wang, J., Luo, Y. M., Farag, D. & Rahman, M., 25 Sept 2020, (E-pub ahead of print) In: Advanced Therapeutics.Research output: Contribution to journal › Article › peer-review
An in vitro bioassay for evaluating the effect of inhaled bronchodilators on airway smooth muscle
Muddle, J., Kanabar, V., Brown, M., Page, C. & Forbes, B., Aug 2020, In: Pulmonary Pharmacology and Therapeutics. 63, 101943.Research output: Contribution to journal › Article › peer-review
In vitro and in vivo antitubercular activity of benzothiazinone-loaded human serum albumin nanocarriers designed for inhalation
Forbes, B., Dec 2020, In: JOURNAL OF CONTROLLED RELEASE.Research output: Contribution to journal › Article › peer-review
Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: Formulation variables and instrumental parameters
Cunha, S., Costa, C. P., Loureiro, J. A., Alves, J., Peixoto, A. F., Forbes, B., Lobo, J. M. S. & Silva, A. C., Jul 2020, In: Pharmaceutics. 12, 7, p. 1-27 27 p., 599.Research output: Contribution to journal › Article › peer-review
Pulmonary Administration: Strengthening the Value of Therapeutic Proximity
Videira, M. A., Llop, J., Sousa, C., Kreutzer, B., Cossío, U., Forbes, B., Vieira, I., Gil, N. & Silva-Lima, B., 27 Feb 2020, In: Frontiers in Medicine. 7, 50.Research output: Contribution to journal › Review article › peer-review
CYCLODEXTRIN-STABILISED ION-PAIR COMPLEXES ENHANCE DRUG LUNG UPTAKE VIA THE POLYAMINE TRANSPORTER
Sofian, Z. M., Wang, J. T. W., Yuan, L., Royall, P., Forbes, B., Barlow, D. J., Page, C., Al-Jamal, K. T., Jones, S. & Benaouda, F., 1 Apr 2019, In: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32, 2, p. A11-A11Research output: Contribution to journal › Meeting Abstract › peer-review
Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages
Selley, L., Schuster, L., Marbach, H., Forsthuber, T., Forbes, B., Gant, T. W., Sandström, T., Camiña, N., Athersuch, T. J., Mudway, I. & Kumar, A., 25 Mar 2020, In: Metallomics : integrated biometal science. 12, 3, p. 371-386 16 p.Research output: Contribution to journal › Article › peer-review
Solid-state epimerisation and disproportionation of pilocarpine HCl: Why we need a 5-stage approach to validate melting point measurements for heat-sensitive drugs
Malallah, O. S., Hammond, B., Al-adhami, T., Buanz, A., Alqurshi, A., Carswell, W. D., Rahman, K. M., Forbes, B. & Royall, P. G., 25 Jan 2020, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 574, p. 1-13 118869.Research output: Contribution to journal › Article › peer-review
A consensus research agenda for optimising nasal drug delivery
Forbes, B., Bommer, R., Goole, J., Hellfritzsch, M., De Kruijf, W., Lambert, P., Caivano, G., Regard, A., Schiaretti, F., Trenkel, M., Vecellio, L., Williams, G., Sonvico, F. & Scherlieβ, R., 1 Jan 2020, In: Expert Opinion On Drug Delivery. 17, 2, p. 127-132 6 p.Research output: Contribution to journal › Article › peer-review
Development of new in vitro models of lung protease activity for investigating stability of inhaled biological therapies and drug delivery systems
Woods, A., Andrian, T., Sharp, G., Bicer, E. M., Vandera, K.-K. A., Patel, A., Mudway, I., Dailey, L. A. & Forbes, B., 1 Jan 2020, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 146, p. 64 - 72 9 p.Research output: Contribution to journal › Article › peer-review
Workshop report: USP workshop on exploring the science of drug absorption
Martinez, M. N., Bhoopathy, S., Carlert, S., Cirit, M., Fahmy, R., Flanagan, T., Forbes, B., Jamei, M., Khan, M. A., Lukacova, V., Mochel, J. P., Pepin, X., Pade, D., Reppas, C., Sinko, P. J., Sperry, D., Tsinman, K. & Vertzoni, M., 1 Aug 2019, In: Dissolution Technologies. 26, 3, p. 38-66 29 p.Research output: Contribution to journal › Article › peer-review
Mucus penetrating properties of soft, distensible lipid nanocapsules
Chen, H., Mansfield, E. D. H., Woods, A., Khutoryanskiy, V. V., Forbes, B. & Jones, S. A., Jun 2019, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 139, p. 76-84 9 p.Research output: Contribution to journal › Article › peer-review
Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging
Wingrove, J. O., Swedrowska, M., Scherliss, R., Parry, M., Ramjeeawon, M., Taylor, D. M., Gauthier, G., Brown, L., Amiel, S. A., Zelaya, F. O. & Forbes, B. J., 28 May 2019, In: JOURNAL OF CONTROLLED RELEASE. 302, p. 140-147 7 p.Research output: Contribution to journal › Article › peer-review
Use of PBPK Modeling to Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products
Hassoun, M., Malmlof, M., Scheibelhofer, O., Kumar, A., Bansal, S., Selg, E., Nowenwik, M., Gerde, P., Radivojev, S., Paudel, A., Arora, S. & Forbes, B., 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1245-1254 10 p.Research output: Contribution to journal › Article › peer-review
A novel method for studying airway hyperresponsiveness in allergic Guinea pigs in vivo using the preciseinhale system for delivery of dry powder aerosols
Lexmond, A. J., Keir, S., Terakosolphan, W., Page, C. P. & Forbes, B., 21 Feb 2018, In: Drug Delivery and Translational Research. 8, 3, p. 760-769 10 p.Research output: Contribution to journal › Article › peer-review
Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs
Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B. & van den Berge, M., 1 Apr 2018, In: Pulmonary Pharmacology and Therapeutics. 49, p. 27-35 9 p.Research output: Contribution to journal › Review article › peer-review
Design and development of a biorelevant simulated human lung fluid
Hassoun, M., Royall, P. G., Harvey, R. D. & Forbes, B., Oct 2018, In: Journal of drug delivery science and technology . 47, p. 485-491Research output: Contribution to journal › Article › peer-review
Glycerol solvates DPPC headgroups and localises in the interfacial regions of model pulmonary interfaces altering bilayer structure
Terakosolphan, W., Trick, J. L., Royall, P. G., Rogers, S. E., Lamberti, O., Lorenz, C. D., Forbes, B. & Harvey, R. D., 8 May 2018, (E-pub ahead of print) In: LANGMUIR.Research output: Contribution to journal › Article › peer-review
Freeze-dried formulations: A new perspective on reformulating naloxone
Courtney, P., Alqurshi, A., Forbes, B., Royall, P. G. & Strang, J., 1 Jun 2017, European Pharmaceutical Review, 22, 3, p. 32-36 5 p.Research output: Contribution to specialist publication › Article
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Carhart-Harris, R. L., Bolstridge, M., Day, C. M. J., Rucker, J., Watts, R., Erritzoe, D. E., Kaelen, M., Giribaldi, B., Bloomfield, M., Pilling, S., Rickard, J. A., Forbes, B., Feilding, A., Taylor, D., Curran, H. V. & Nutt, D. J., Feb 2018, In: Psychopharmacology. 29, 3, p. 399–408 10 p.Research output: Contribution to journal › Article › peer-review
Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth)
Malallah, O. S., Garcia, C. M. A., Proctor, G. B., Forbes, B. & Royall, P. G., 6 Feb 2018, (E-pub ahead of print) In: INTERNATIONAL JOURNAL OF PHARMACEUTICS.Research output: Contribution to journal › Article › peer-review
Ion-Pairing with Spermine Targets Theophylline to the Lungs via the Polyamine Transport System
Benaouda, F., Jones, S. A., Chana, J., Dal Corno, B. M., Barlow, D. J., Hider, R. C., Page, C. P. & Forbes, B., 5 Mar 2018, In: Molecular Pharmaceutics. 15, 3, p. 861-870 10 p.Research output: Contribution to journal › Article › peer-review
Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs
Bäckman, P., Arora, S., Couet, W., Forbes, B., de Kruijf, W. & Paudel, A., 25 Oct 2017, (E-pub ahead of print) In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES.Research output: Contribution to journal › Article › peer-review
A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture
Bosquillon, C., Madlova, M., Patel, N., Clear, N. & Forbes, B., 18 Sept 2017, (E-pub ahead of print) In: Pharmaceutical Research. p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
In Silico and in Vitro Screening for P-Glycoprotein Interaction with Tenofovir, Darunavir, and Dapivirine: An Antiretroviral Drug Combination for Topical Prevention of Colorectal HIV Transmission
Swedrowska, M., Jamshidi, S., Kumar, A., Kelly, C., Rahman, K. M. & Forbes, B., 7 Aug 2017, In: Molecular Pharmaceutics. 14, 8, p. 2660-2669 10 p.Research output: Contribution to journal › Article › peer-review
Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
Kumar, A., Bicer, E. M., Pfeffer, P., Monopoli, M. P., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M., Behndig, A. F., Blomberg, A., Somers, G., Hassall, D., Dailey, L. A., Forbes, B. & Mudway, I., 22 Jun 2017, (E-pub ahead of print) In: Nanomedicine-Nanotechnology Biology And Medicine. 13, 8, p. 2517-2521Research output: Contribution to journal › Article › peer-review
A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition
Kumar, A., Terakosolphan, W., Hassoun, M., Vandera, K.-K., Novicky, A., Harvey, R., Royall, P. G., Bicer, E. M., Eriksson, J., Edwards, K., Valkenborg, D., Nelissen, I., Hassall, D., Mudway, I. & Forbes, B., 30 May 2017, (E-pub ahead of print) In: Pharmaceutical Research. p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Drug Delivery Devices for Inhaled Medicines
Lexmond, A. & Forbes, B., 4 Nov 2016, Handbook of Experimental Pharmacology. Springer New York LLC, Vol. 237. p. 265-280 16 p. (Handbook of Experimental Pharmacology; vol. 237).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs
Ehrhardt, C., Bäckman, P., Couet, W., Edwards, C., Forbes, B., Fridén, M., Gumbleton, M., Hosoya, K.-I., Kato, Y., Nakanishi, T., Takano, M., Terasaki, T. & Yumoto, R., 15 Apr 2017, (E-pub ahead of print) In: Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › peer-review
Mixed micelles of lipoic acid-chitosan-poly(ethylene glycol) and distearoylphosphatidylethanolamine-poly(ethylene glycol) for tumor delivery
Elsaid, Z., Taylor, K. M. G., Puri, S., Eberlein, C. A., Al-Jamal, K., Bai, J., Klippstein, R., Wang, J. T. W., Forbes, B., Chana, J. & Somavarapu, S., 1 Apr 2017, In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 101, p. 228-242 15 p.Research output: Contribution to journal › Article › peer-review
Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery
Martinelli, F., Balducci, A. G., Kumar, A., Sonvico, F., Forbes, B., Bettini, R. & Buttini, F., 30 Jan 2017, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 517, 1-2, p. 286-295 10 p.Research output: Contribution to journal › Article › peer-review
Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks
Muddle, J., Kirton, S. B., Parisini, I., Muddle, A., Murnane, D., Ali, J., Brown, M., Page, C. & Forbes, B., Jan 2017, In: Journal of Pharmaceutical Sciences. 106, 1, p. 313–321Research output: Contribution to journal › Article › peer-review
Current practice of preparing morphine infusions for nurse/patient-controlled analgesia in a UK paediatric hospital: healthcare professionals’ views and experiences
Rashed, A. N., Tomlin, S., Forbes, B. J. & Whittlesea, C. M. C., 2018, In: European journal of hospital pharmacy-Science and practice. 25, p. 327-330Research output: Contribution to journal › Article › peer-review
The influence of electrostatic properties on the punch sticking propensity of pharmaceutical blends
Samiei, L., Kelly, K., Taylor, L., Forbes, B., Collins, E. & Rowland, M., 1 Jan 2017, In: POWDER TECHNOLOGY. 305, p. 509-517 9 p.Research output: Contribution to journal › Article › peer-review
Research

Medicines Development
The Medicines Development Research Group develops novel materials, formulations, drug delivery devices, manufacturing, analytical, and digital technologies.

Antimicrobial Research Theme
Antimicrobial Research Theme
News
King's engineer leading research project on rapid vaccine manufacture
WellcomeLEAP grant for rapid vaccine manufacture

KC Wong Postdoctoral Fellowships now open
The School of Cancer & Pharmaceutical Sciences are pleased to open applications for KC Wong Fellowships.

Six new Studentships for Institute of Pharmaceutical Science
The School of Cancer & Pharmaceutical Science are pleased to announce that there are six new studentships within the Institute of Pharmaceutical Sciences.
