Dr Adam C. Sedgwick

Lecturer in Chemistry

Contact details

Adam.sedgwick@kcl.ac.uk

Biography

Dr Adam Sedgwick is a Lecturer in Chemistry in the Department of Chemistry at King's College London. He joined King’s College London as a Lecturer in Chemistry in 2023.

He received his MChem (2014) and his PhD (2018) from the University of Bath under the supervision of Professor Tony D. James and Professor Steven D. Bull. Subsequently, Adam moved to the US to work within the group of Professor Jonathan L Sessler at the University of Texas at Austin (2018–2021).

From 2021-2023, he was a Glasstone Research Fellow at the University of Oxford and a Junior Research Fellow at Jesus College. Adam’s research interests are towards synthetic method development for biomedical applications.

Research Interests

Molecular imaging
Medicinal chemistry
Organic/inorganic synthesis
Chemical biology

Teaching

Chemistry for Disease and Therapeutics
UG Research Methods Literature Review
MSci Research Project & Dissertation
MRes Research Project in Interdisciplinary Chemistry

Research profile

For more information on Dr Sedgwick's research please see his Research Portal page

The Sedgwick Group

Postgraduate Researchers

Jake Vickery
Raouf El-Dabl
Tanrui Sheng

The Sedgwick Group is a new research group at King’s that designs molecular imaging strategies to aid drug development, disease diagnosis, and improve our fundamental understanding in chemical biology.

Real-time Visualization of Epileptic Seizures Using Photoacoustic Imaging with a Peroxynitrite-Responsive Manganese(II) Texaphyrin
Sedgwick, A., 2025, Chemical Science.
Research output: Contribution to specialist publication › Article
The activity of therapeutic molecular cluster Ag5 is dependent on oxygen level and HIF-1 mediated signalling
Sedgwick, A., 22 Aug 2024, Redox Biology, 76.
Research output: Contribution to specialist publication › Article
Fluorogenic Platinum(IV) Complexes as Potential Predictors for the Design of Hypoxia-Activated Platinum(IV) Prodrugs
Sedgwick, A., Diez Perez, I. & Musgrave, R., 13 Aug 2024, Dalton Transactions, 53, 35, p. 14811-14816 6 p.
Research output: Contribution to specialist publication › Article
Lutetium Texaphyrin-Celecoxib Conjugate as a Potential Immuno-Photodynamic Therapy Agent
Sedgwick, A., 18 Jun 2024, (Accepted/In press) In: Journal of The American Chemistry Society.
Research output: Contribution to journal › Article › peer-review
A colorimetric approach for monitoring the reduction of platinum (IV) complexes in aqueous solution
Huang, S., Marsh, J. W., White, J. R. G., Ha, T. Q., Twigger, S. A., Diez-Perez, I. & Sedgwick, A. C., 10 Apr 2024, In: NEW JOURNAL OF CHEMISTRY. 48, 17, p. 7548-7551 4 p.
Research output: Contribution to journal › Article › peer-review
Lutetium texaphyrin: A photocatalyst that triggers pyroptosis via biomolecular photoredox catalysis
Sedgwick, A., 27 Feb 2024, In: PNAS. 121, 9, p. e2314620121 e2314620121.
Research output: Contribution to journal › Article › peer-review
Targeted Cyclo[8]pyrrole-Based NIR-II Photoacoustic Tomography Probe for Suppression of Orthotopic Pancreatic Tumor Growth and Intra-abdominal Metastases
Chen, J., Chen, R., Chau, C. V., Sedgwick, A. C., Xue, Q., Chen, T., Zeng, S., Chen, N., Wong, K. K. Y., Song, L., Ren, Y., Yang, J., Sessler, J. L. & Liu, C., 8 Feb 2024, In: Journal of the American Chemical Society. 146, 7, p. 4620-4631 12 p.
Research output: Contribution to journal › Article › peer-review
Deferasirox Derivatives: Ligands for the Lanthanide Series
Mangel, D. N., Juarez, G. J., Carpenter, S. H., Steinbrueck, A., Lynch, V. M., Yang, J., Sedgwick, A. C., Tondreau, A. & Sessler, J. L., 11 Oct 2023, In: Journal of the American Chemical Society. 145, 40, p. 22206-22212 7 p.
Research output: Contribution to journal › Article › peer-review
Enhancement of sonochemical production of hydroxyl radicals from pulsed cylindrically converging ultrasound waves
Sedgwick, A., Oct 2023, In: Ultrasonics Sonochemistry. 99, p. 106559 106559.
Research output: Contribution to journal › Article › peer-review
Oxali(IV)Fluors: Fluorescence Responsive Oxaliplatin(IV) Complexes Identify a Hypoxia-Dependent Reduction in Cancer Cells
Boulet, M. H. C., Bolland, H. R., Hammond, E. M. & Sedgwick, A., 21 Jun 2023, In: Journal of the American Chemical Society. 145, 24, p. 12998–13002 5 p.
Research output: Contribution to journal › Article › peer-review

Research

The Multiscale Biofilm Research Hub (MBRH)

The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.

Antimicrobial resistance and biofilm therapeutics

Work involves understanding how biofilms contribute to antimicrobial resistance and the creation of new anti-biofilm therapeutics.

Project status: Ongoing

Synthetic biology and technological advancements

Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.

Project status: Ongoing

Microbes in Health & Disease

The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.