Dr Aakruti Kaikini is a Research Associate in the Department of Diabetes and Obesity, School of Cardiovascular Medicine & Sciences. She works in Dr Afshan Malik’s lab within the Mitochondria & Diabetes Research Group on a funded by the charity, Alzheimer’s Research UK. The project aims at investigating mitochondria in diabetic and non-diabetic Alzheimer’s disease to understand the underlying disease mechanisms using post-mortem human brain tissues.

Aakruti has completed PhD from Institute of Chemical Technology, Mumbai, India. Her doctoral research explored the role of hyperglycemia-induced oxidative stress and mitochondrial dysfunction in diabetic nephropathy pathogenesis and treatment strategies for its mitigation. After her PhD, she worked as a postdoctoral researcher at the Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland on mitochondrial dysfunction in non-alcoholic fatty liver disease.

Publications

• Ethyl ferulate, a lipophilic phenylpropanoid, prevents diabetes-associated renal injury in rats by amelioration of hyperglycemia-induced oxidative stress via activation of nuclear factor erythroid 2-related factor 2. Kaikini A, Muke S, Peshattiwar V, Bagle S, Dighe V, Sathaye S. Feb 2021, In: Journal of Food Biochemistry. 45, 4, e13607. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/jfbc.13607
• Standardization of type 1 and type 2 diabetic nephropathy models in rats: Assessment and characterization of metabolic features and renal injury. Kaikini A, Dhodi D, Muke S, Peshattiwar V, Bagle S, Korde A, Sarnaik J, Kadwad V, Sachdev S Sathaye S. July 2020, In: Journal of Pharmacy and Bioallied Sciences. 12,3, 295-307. Research output: Contribution to journal › Article › peer-review. DOIs: 10.4103/jpbs.JPBS_239_19
• Vasant Kusmakar Ras, an ayurvedic herbo-mineral formulation prevents the development of diabetic retinopathy in rats. Tamoli SM, Kohli KR, Kaikini AA, Muke SA, Shaikh AA, Sathaye S. July 2020, In: Journal of Ayurveda and integrative medicine. 11,3, 270-276. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jaim.2020.02.002
• Protocols for Cellular Evaluation of Targeted Drug Delivery Systems for Cancer and Infectious Diseases. Kaikini A, Peshattiwar V, Devarajan PV, Dandekar P, Sathaye S. 2019, Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis. Springer, Cham, p. 523-544 p. (AAPS Advances in the Pharmaceutical Sciences Series; vol 39) Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review. DOIs: https://doi.org/10.1007/978-3-030-29168-6_18
• In Vitro and In Vivo Models for Cancer and Infectious Diseases. Peshattiwar V, Kaikini A, Devarajan PV, Dandekar P, Sathaye S. 2019, Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis. Springer, Cham, p. 483–519 p. (AAPS Advances in the Pharmaceutical Sciences Series; vol 39) Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review. DOIs: https://doi.org/10.1007/978-3-030-29168-6_17
• Targeting mitochondrial dysfunction for the treatment of diabetic complications: Pharmacological interventions through natural products. Kaikini AA, Kanchan DM, Nerurkar UV, Sathaye S. July 2017, In: Pharmacognosy Reviews. 11,22,128. Research output: Contribution to journal › Article › peer-review. DOIs: 10.4103/phrev.phrev_41_16
• Thymol, a monoterpene, inhibits aldose reductase and high-glucose-induced cataract on isolated goat lens. Kanchan DM, Kale SS, Somani GS, Kaikini AA, Sathaye S. October 2016, In: Journal of Pharmacy & Bioallied Sciences.8,4,277. Research output: Contribution to journal › Article › peer-review. DOIs: 10.4103/0975-7406.199348
• Renoprotective effect of diosgenin in streptozotocin induced diabetic rats. Kanchan DM, Somani GS, Peshattiwar VP, Kaikini AA, Sathaye S. April 2016, In: Pharmacological Reports. 68, 2, 370-377. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.pharep.2015.10.011