Some molecules are exclusively toxic to biological systems and classified as being non-essential, others are essential for life. Nevertheless, above certain threshold concentrations all compounds (including essential ones) become toxic. Homeostasis of essential elements and detoxification of non-essential elements are thus vital drivers of well-being, longevity and survival. The identification and characterization of these intricate pathways form the foundations of Toxicogenomics.

By exploiting genomic, proteomic and toxicological tools within model species (the nematode C.elegans) as well as key environment organisms (the earthworm), we aim to expand the horizon of Toxicogenomics.