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Saeed Shoaie

Dr Saeed Shoaie

Senior Lecturer in Systems & Synthetic Biology

Research interests

  • Host-Microbiome Interactions

Biography

Dr Saeed Shoaie is the group leader of Translational Systems Biology in the CHMI. He has been a BBSRC and EPSRC UKRI fellow since 2018 and the Deputy Lead of the MSc in Microbiome at King's College London.

He received his MSc and PhD degrees in Innovative and Sustainable Chemical Engineering and in Systems and Synthetic Biology of Host-Microbiome Interactions, from Professor Jens Nielsen's Systems Biology lab at Chalmers University of Technology, Sweden. He worked as a researcher at Novo Nordisk A/S and Steno Diabetic Center in Denmark, and Science for Life Laboratory in Sweden, before he was appointed as a Lecturer in Systems and Synthetic Biology at King's.

His research activities focus on analysing multi-omics data in different cohort studies with the aim of identifying biomarkers and novel treatment strategies for human diseases. He is also interested in the generation of genome-scale metabolic models for host and microbiome, using these models as a scaffold to analyse omics data with the objective to elucidate the host-microbiome interactions in different human disorders. 

His lab develop systems biology and bioinformatics tools that are a necessary component to perform integrated analysis and apply them in personalised medical research. He has also developed a mathematical platform that makes it possible to predict how different patients will respond to a modified diet, depending on the composition of each individual gut microbiome. This study has been published in Cell Metabolism and covered by more than 100 journals around the world. His research group are currently improving the approach in order to design a personalized diet regime based on the individual gut microbiome for early prevention of metabolic disorders. These studies will assist in the determination of what could take months of trial and error. This synthesis of modern tools and capacities with the ancient privilege of the doctor-patient relationship will provide personalised care.

    Research

    MIMSA - Oral Microbiome & Mucosal Immunity in COVID-19 disease

    Examining the role of 'mucosal immunity' and the 'oral microbiome' in COVID severity, and the differences seen between South Asian & white ethnic groups.

    Project status: Starting

    pg23-pg-aq-fodocs-gut-microbiome
    Centre for Host-Microbiome Interactions

    Millions of microorganisms live in and on our bodies forming microbiomes on different surfaces. Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer’s disease.

    Hero_Microbes_RIG-thumbnail
    Microbes in Health & Disease

    The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.

    News

    Microbiome changes in chronic liver disease highlight the need for personalised treatment

    People with chronic liver disease have dramatic changes to the types and functions of bacteria in the gut and mouth, a new study has revealed.

    Liver graphic

    “Transient” gut bacteria may affect health and guide diet choices

    ‘Transient’ populations of gut bacteria may contribute to the development of chronic liver disease and diabetes, but a personalised diet plan could lessen the...

    TCS gut thumbnail

    New gut microbiome atlas builds most accurate profile of global gut health to date

    Research could help doctors around the world better understand how bacteria in the gut cause disease and how to treat them.

    Saeed gut microbiome

    New collaborative study maps effects of dietary nutrients on disease

    Researchers from King’s College London and the Francis Crick Institute have created a tool to predict the effects of different diets on both cancerous cells...

    foods in test tubes

    Academic Promotions at the Faculty of Dentistry, Oral & Craniofacial Sciences

    Very many congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial Sciences who were awarded academic promotion during the...

    A red flag with the King's College London logo

    Investigating the role of bacterial folate and homocysteine in metabolism in Parkinson's Disease

    Academics from King’s College London’s Centre for Host-Microbiome Interactions recognised the need for a better understanding of the role of gut microbiota in...

    saeed-microbiome-parkinsons-image

      Research

      MIMSA - Oral Microbiome & Mucosal Immunity in COVID-19 disease

      Examining the role of 'mucosal immunity' and the 'oral microbiome' in COVID severity, and the differences seen between South Asian & white ethnic groups.

      Project status: Starting

      pg23-pg-aq-fodocs-gut-microbiome
      Centre for Host-Microbiome Interactions

      Millions of microorganisms live in and on our bodies forming microbiomes on different surfaces. Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer’s disease.

      Hero_Microbes_RIG-thumbnail
      Microbes in Health & Disease

      The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.

      News

      Microbiome changes in chronic liver disease highlight the need for personalised treatment

      People with chronic liver disease have dramatic changes to the types and functions of bacteria in the gut and mouth, a new study has revealed.

      Liver graphic

      “Transient” gut bacteria may affect health and guide diet choices

      ‘Transient’ populations of gut bacteria may contribute to the development of chronic liver disease and diabetes, but a personalised diet plan could lessen the...

      TCS gut thumbnail

      New gut microbiome atlas builds most accurate profile of global gut health to date

      Research could help doctors around the world better understand how bacteria in the gut cause disease and how to treat them.

      Saeed gut microbiome

      New collaborative study maps effects of dietary nutrients on disease

      Researchers from King’s College London and the Francis Crick Institute have created a tool to predict the effects of different diets on both cancerous cells...

      foods in test tubes

      Academic Promotions at the Faculty of Dentistry, Oral & Craniofacial Sciences

      Very many congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial Sciences who were awarded academic promotion during the...

      A red flag with the King's College London logo

      Investigating the role of bacterial folate and homocysteine in metabolism in Parkinson's Disease

      Academics from King’s College London’s Centre for Host-Microbiome Interactions recognised the need for a better understanding of the role of gut microbiota in...

      saeed-microbiome-parkinsons-image