Biography
I am the Deputy Director for the UK Dementia Research Institute at King's College London and a van Geest Professor of Neurodegeneration. I am recognised as an expert in the cell biology of Alzheimer’s disease, and I specifically focus on the cellular and molecular underpinnings of amyloid formation and synapse loss that characterize Alzheimer’s. My lab uses both cell and systems biology approaches, with our aim being to disentangle the complexity of the disease process.
Please see my Research Staff Profile for more detail
Key Publications:
- Rajendran et al., 2008. Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting. Science.
- Rajendran et al., 2010. Subcellular targeting strategies for drug design and delivery. Nat Rev Drug Discov.
- Paolicelli et al., 2017. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron.
Research
King’s Open Research Group Initiative (KORGI)
The King’s Open Research Group Initiative (or KORGI) is an action-oriented committee composed of an interdisciplinary mix of senior academics and experienced research staff that seek to change policy and procedures to promote transparent, accessible and reproducible research.
Features
IoPPN Inaugural Lectures: 2017-2019
Inaugural lectures are given by newly arrived or promoted professors, who use the opportunity to introduce themselves, to present an overview of their own...
Research
King’s Open Research Group Initiative (KORGI)
The King’s Open Research Group Initiative (or KORGI) is an action-oriented committee composed of an interdisciplinary mix of senior academics and experienced research staff that seek to change policy and procedures to promote transparent, accessible and reproducible research.
Features
IoPPN Inaugural Lectures: 2017-2019
Inaugural lectures are given by newly arrived or promoted professors, who use the opportunity to introduce themselves, to present an overview of their own...