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Laura Mantoan Ritter

Dr Laura Mantoan Ritter MD MRCP(UK)PhD (CSCN) Diplomate (EEG) FHEA

Consultant Neurologist and Adjunct Reader

Research interests

  • Neuroscience

Biography

My group investigates novel diagnostic and therapeutic tools and precision treatments for super-refractory and genetic forms of epilepsy.

My research interest is:

  1. The mechanistic target of rapamycin (mTOR) signalling pathway, which regulates fundamental cellular processes including growth control, autophagy and metabolism. With my co-investigators Prof Joseph Bateman and Prof Deb Pal, I lead an MRC/NIHR-funded National rare disease clinical and research node for mTOR pathway diseases. My group investigates novel somatic mTOR pathway mutations in human epilepsy surgical tissue by next-generation sequencing and develops novel genetic “liquid biopsy” tools.
  2. New-onset refractory status epilepticus (NORSE): My group investigates novel diagnostic tools (metagenomic and astrovirus sequencing, cytokine assays, neuropathology) and the effectiveness of vagal nerve stimulation in aborting unremitting status epilepticus, modulate ictogenesis and reduce long-term seizure burden.

Find out more about my research:

Key Collaborators:

  • Professor Joseph Bateman, King's College London
  • Professor Deb Pal, King's College London
  • Professor Mathew Walker, University College London
  • Dr Claire Troakes, King's College London

 

News

£1.1 million NIHR/MRC node established to study mTOR pathway rare diseases

Professor Joseph Bateman, Professor Deb Pal and Dr Laura Mantoan-Ritter received the funding to establish the mTOR Pathway Diseases node as part of the new...

Bateman_MantoanRitter_Image

News

£1.1 million NIHR/MRC node established to study mTOR pathway rare diseases

Professor Joseph Bateman, Professor Deb Pal and Dr Laura Mantoan-Ritter received the funding to establish the mTOR Pathway Diseases node as part of the new...

Bateman_MantoanRitter_Image