
Dr Andrew Chan
Reader
Research interests
- Imaging sciences
Biography
Dr Chan obtained his MEng (2001) and PhD (EPSRC Industrial CASE AWARD 2004, Supervisor: Prof Sergei G. Kazarian) at Imperial College London. He then became a research associate in Prof Kazarian's group between 2004 and 2012 including time as an EPSRC Life Science Interface (LSI) fellow between 2006 and 2009. While an EPSRC LSI fellow, Dr Chan spent 1 year (2007) in Rutgers University, Newark, USA, with Prof Richard Mendelsohn's group as a visiting researcher.
In 2012 and 2018, Dr Chan respectively acquired the Lectureship and Senior Lectureship in Pharmaceutical Molecular Spectroscopy in the Institute of Pharmaceutical Science at King’s College London. In 2014, he joined as a committee member, and as the Event Secretary in 2019, in the Joint Pharmaceutical and Analysis Group (JPAG). He is an editorial board member of the journal Scientific Reports. Dr Chan has published over 70 peer-reviewed research articles and book chapters primarily in the development of novel applications of Fourier Transform Infrared (FTIR) spectroscopy for testing pharmaceutical formulations and biological systems. One of his main research interests is focused on the application of FTIR spectroscopy and imaging to study live cells-drug interactions.
Dr Chan has been awarded the Weinberg Prize in 2004 (Imperial College London, Department of Chemical Engineering) for his PhD and the Hounsfield poster prize in 2009 (Imperial College London) for his bio-spectroscopic research. He currently has an h-index of 31 according to the Web Of Knowledge.
Non-salt based co-amorphous formulation produced by freeze-drying
Suleiman Alsalhi, M., Royall, P. G., Al-Obaidi, H., Alsalhi, A., Cilibrizzi, A. & Chan, K. L. A., 15 Oct 2023, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 645, 123404.Research output: Contribution to journal › Article › peer-review
Opto-Lipidomics of Tissues
Jensen, M., Liu, S., Stepula, E., Martella, D., Birjandi, A. A., Farrell-Dillon, K., Chan, K. L. A., Parsons, M., Chiappini, C., Chapple, S. J., Mann, G. E., Vercauteren, T., Abbate, V. & Bergholt, M. S., 2023, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Characterising the chemical and physical properties of phase-change nanodroplets
Zhang, W., Metzger, H., Vlatakis, S., Claxton, A., Carbajal, M., Fung, L. F., Mason, J., Chan, A., Pouliopoulos, A., Fleck, R., Prentice, P. & Thanou, M., 31 May 2023, In: Ultrasonics Sonochemistry. 97, 106445.Research output: Contribution to journal › Article › peer-review
Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug
Alsalhi, M. S., Royall, P. G. & Chan, K. L. A., 29 Jun 2022, In: RSC Advances. 12, 30, p. 19040-19053 14 p.Research output: Contribution to journal › Article › peer-review
Label-free study of intracellular glycogen level in Metformin and Resveratrol-treated insulin-resistant HepG2 by live-cell FTIR spectroscopy
Poonprasartporn, A. & Chan, K. L. A., 15 Sept 2022, In: Biosensors and Bioelectronics. 212, 114416.Research output: Contribution to journal › Article › peer-review
Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch
Benaouda, F., Inacio, R., Lim, C. H., Park, H., Pitcher, T., Alhnan, M. A., Aly, M. M. S., Al-jamal, K. T., Chan, K.-L., Gala, R. P., Sebastia-saez, D., Cui, L., Chen, T., Keeble, J. & Jones, S. A., 3 May 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 18, p. e2120340119 e2120340119.Research output: Contribution to journal › Article › peer-review
Illuminating host-parasite interaction at the cellular and subcellular levels with infrared microspectroscopy
Elsheikha, H. M., Al-Sandaqchi, A., Harun, M., Winterton, F., Altharawi, A., Elsaied, N. A., Stevenson, C., Nottingham, U., Mina, J., Cinque, G. & Chan, A., 1 Feb 2022, In: Cells. 11, 5, 811.Research output: Contribution to journal › Article › peer-review
Amino acid hydrotropes to increase the solubility of indomethacin and carbamazepine in aqueous solution
Alsalhi, M. S. & Chan, K. L. A., 5 Apr 2022, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 617, 121591.Research output: Contribution to journal › Article › peer-review
High throughput study of ionic liquids in controlled environments with FTIR spectroscopic imaging
Chan, A., Kazarian, S. G., Shalygin, A., Martyanov, O. & Welton, T., 1 Sept 2021, In: JOURNAL OF MOLECULAR LIQUIDS. 337, 116412.Research output: Contribution to journal › Article › peer-review
Inexpensive Portable Infrared Device to Detect and Quantify Alcohols in Hand Sanitizers for Public Health and Safety
Ng, J. K., Tay, F. H., Wray, P. S., Mohd Saberi, S. S., Ting, K. K. K., Khor, S. M. & Chan, K. L. A., 3 Nov 2021, (E-pub ahead of print) In: Analytical Chemistry. 93, 45, p. 15015–15023Research output: Contribution to journal › Article › peer-review
In vitro Fourier transform infrared spectroscopic study of the effect of glycerol on the uptake of beclomethasone dipropionate in living respiratory cells
Terakosolphan, W., Altharawi, A., Poonprasartporn, A., Harvey, R. D., Forbes, B. & Chan, K. L. A., 20 Nov 2021, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 609, 121118.Research output: Contribution to journal › Article › peer-review
Live cell ATR-FTIR spectroscopy as a novel bioanalytical tool for cell glucose metabolism research
Poonprasartporn, A. & Andrew Chan, K. L., Jun 2021, In: Biochimica et biophysica acta-Molecular cell research. 1868, 7, p. 119024 119024.Research output: Contribution to journal › Article › peer-review
In vitro growth-and encystation-inhibitory efficacies of matcha green tea and epigallocatechin gallate against acanthameoba castellanii
Dickson, A., Cooper, E., Fakae, L. B., Wang, B., Chan, K. L. A. & Elsheikha, H. M., Sept 2020, In: Pathogens. 9, 9, p. 1-15 15 p., 763.Research output: Contribution to journal › Article › peer-review
Synchrotron Photothermal Infrared Nanospectroscopy of Drug-Induced Phospholipidosis in Macrophages
Chan, K. L. A., Lekkas, I., Frogley, M., Cinque, G., Altharawi, A., Bello, G. & Dailey, L. A., 16 Jun 2020, In: Analytical Chemistry. 92, 12, p. 8097-8107 11 p.Research output: Contribution to journal › Article › peer-review
Identifying the responses from the estrogen receptor expressed MCF7 cells treated in anticancer drugs of different modes of action using live-cell FTIR spectroscopy
Altharawi, A., Rahman, M. & Chan, A., 22 May 2020, In: ACS Omega. 5, 22, p. 12698–12706 9 p., acsomega.9b04369.Research output: Contribution to journal › Article › peer-review
Tracking glycosylation in live cells using FTIR spectroscopy
Phelan, J., Altharawi, A. I. & Chan, A., May 2020, In: TALANTA. 211, 120737.Research output: Contribution to journal › Article › peer-review
Transmission Fourier Transform Infrared Spectroscopic Imaging, Mapping, and Synchrotron Scanning Microscopy with Zinc Sulfide Hemispheres on Living Mammalian Cells at Sub-Cellular Resolution
Chan, K. L. A., Altharawi, A. I., Fale, P., Song, C. L., Kazarian, S. G., Cinque, G., Untereiner, V. & Sockalingum, G. D., 1 May 2020, In: APPLIED SPECTROSCOPY. 74, 5, p. 544-552 9 p.Research output: Contribution to journal › Article › peer-review
Atmospheric microplastic deposition in an urban environment and an evaluation of transport
Wright, S. L., Ulke, J., Font Font, A. M., Chan, K. L. A. & Kelly, F. J., 31 Dec 2019, In: Environment International. 136, p. 105411 105411.Research output: Contribution to journal › Article › peer-review
Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR
Elsheikha, H. M., Elsaied, N. A., Chan, K. L. A., Brignell, C., Harun, M. S. R., Wehbe, K. & Cinquee, G., 21 May 2019, In: Analytical Methods. 11, 19, p. 2518-2530 13 p.Research output: Contribution to journal › Article › peer-review
Towards identifying the mode of action of drugs using live-cell FTIR spectroscopy
Altharawi, A., Rahman, K. M. & Chan, K. L. A., 21 Apr 2019, In: Analyst. 144, 8, p. 2725-2735 11 p.Research output: Contribution to journal › Article › peer-review
Subcellular mapping of living cells via synchrotron microFTIR and ZnS hemispheres
Chan, K. L. A., Fale, P. L. V., Atharawi, A., Wehbe, K. & Cinque, G., 1 Jan 2018, (Accepted/In press) In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY.Research output: Contribution to journal › Article › peer-review
A combined FTIR and DSC study on the bilayer-stabilising effect of electrostatic interactions in ion paired lipids
Schmid, M., Wölk, C., Giselbrecht, J., Chan, K. L. A. & Harvey, R. D., 18 May 2018, In: Colloids And Surfaces B-Biointerfaces.Research output: Contribution to journal › Article › peer-review
In-situ freeze-drying - forming amorphous solids directly within capsules: An investigation of dissolution enhancement for a poorly soluble drug
Alqurshi, A., Royall, P. G. & Chan, K. L. A., 6 Jun 2017, In: Scientific Reports. 7, 2910.Research output: Contribution to journal › Article › peer-review
Preventing damage of germanium optical material in attenuated total reflection-Fourier transform infrared (ATR-FTIR) studies of living cells
Fale, P. L. V. & Chan, K. L. A., 21 Jul 2016, In: VIBRATIONAL SPECTROSCOPY.Research output: Contribution to journal › Article › peer-review
Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells
Chan, A. & Kazarian, S. G., 29 Mar 2016, In: CHEMICAL SOCIETY REVIEWS. 45, 7, p. 1850-64 15 p.Research output: Contribution to journal › Article › peer-review
Solvent-Free Click-Mechanochemistry for the Preparation of Cancer Cell Targeting Graphene Oxide
Rubio Carrero, N., Mei, K.-C., Klippstein Martin, R., Coutinho Da Costa, P. M., Hodgins, N., Wang, J.T.-W., Festy, F., Abbate, V., Hider, R. C., Chan, K. L. A. & Al-Jamal, K. T., 17 Aug 2015, (E-pub ahead of print) In: ACS Applied Materials and Interfaces. 7, 34, p. 18920–18923Research output: Contribution to journal › Letter › peer-review
In situ Fourier transform infrared analysis of live cells' response to doxorubicin
Vieira Fale, P., Altharawi, A. & Chan, K. L. A., 1 Oct 2015, In: Biochimica et biophysica acta-Molecular cell research. 1853, 10 Part A, p. 2640-2648 9 p.Research output: Contribution to journal › Article › peer-review
Label-free optical imaging of live cells
Chan, K. L. A. & Vieira Fale, P., Jun 2015, Biophotonics for Medical Applications. Meglinski, I. (ed.). 1 ed. Woodhead Publishing Limited, p. 213-241 29 p. (Woodhead Publishing series in biomaterials; no. 82).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
A Central Neural Pathway Controlling Odor Tracking in Drosophila
Slater, G., Levy, P., Chan, K. L. A. & Larsen, C., 4 Feb 2015, In: Journal of neuroscience. 35, 5, p. 1831-1848 18 p.Research output: Contribution to journal › Article › peer-review
Label-Free in Situ Quantification of Drug in Living Cells at Micromolar Levels Using Infrared Spectroscopy
Chan, K. L. A. & Vieira Fale, P. L., 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11673-11679 7 p.Research output: Contribution to journal › Article › peer-review
FTIR Spectroscopic Study of Poly(Ethylene Glycol)–Nifedipine Dispersion Stability in Different Relative Humidities
Iqbal, W. S. & Chan, K. L. A., Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 1, p. 280-284 5 p.Research output: Contribution to journal › Article › peer-review
Dissolution of solid dispersions of ibuprofen studied by Fourier transform infrared imaging
Chan, K. & Kazarian, S., 2006, WASHINGTON: AMER CHEMICAL SOC. 12 p. (ACS SYMPOSIUM SERIES; vol. 924)Research output: Book/Report › Book
Combined application of imaging methods for the characterization of a polymer blend
Gupper, A., Wilhelm, P., Schmied, M., Kazarian, S., Chan, K. & Reussner, J., Dec 2002, In: APPLIED SPECTROSCOPY. 56, 12, p. 1515-1523 9 p.Research output: Contribution to journal › Article › peer-review
Confocal Raman microscopy of supercritical fluid dyeing of polymers
Kazarian, S. & Chan, K., 2003, In: Analyst. 128, 5, p. 499-503 5 p.Research output: Contribution to journal › Article › peer-review
New opportunities in micro- and macro-attenuated total reflection infrared spectroscopic imaging: Spatial resolution and sampling versatility
Chan, K. & Kazarian, S., Apr 2003, In: APPLIED SPECTROSCOPY. 57, 4, p. 381-389 9 p.Research output: Contribution to journal › Article › peer-review
Applications of attenuated total reflection infrared spectroscopic imaging to pharmaceutical formulations
Chan, K., Hammond, S. & Kazarian, S., 1 May 2003, In: Analytical Chemistry. 75, 9, p. 2140-2146 7 p.Research output: Contribution to journal › Article › peer-review
"Chemical photography" of drug release
Kazarian, S. & Chan, K., 30 Dec 2003, In: MACROMOLECULES. 36, 26, p. 9866-9872 7 p.Research output: Contribution to journal › Article › peer-review
FTIR imaging of polymeric materials under high-pressure carbon dioxide
Kazarian, S. & Chan, K., 27 Jan 2004, In: MACROMOLECULES. 37, 2, p. 579-584 6 p.Research output: Contribution to journal › Article › peer-review
Polymorphism and devitrification of nifedipine under controlled humidity: a combined FT-Raman, IR and Raman microscopic investigation
Chan, K., Fleming, O., Kazarian, S., Vassou, D., Chryssikos, G. & Gionis, V., May 2004, In: JOURNAL OF RAMAN SPECTROSCOPY. 35, 5, p. 353-359 7 p.Research output: Contribution to journal › Article › peer-review
FT-IR imaging and Raman microscopic study of poly(ethylene terephthalate) film processed with supercritical CO2
Fleming, O., Chan, K. & Kazarian, S., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 3-7 5 p.Research output: Contribution to journal › Article › peer-review
Water vapour-induced mesoporous structure collapse observed by VGI and FT-IR spectroscopy
Jervis, H., Kazarian, S., Chan, K., Bruce, D. & King, N., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 225-231 7 p.Research output: Contribution to journal › Article › peer-review
An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution
van der Weerd, J., Chan, K. & Kazarian, S., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 9-13 5 p.Research output: Contribution to journal › Article › peer-review
Visualisation of the heterogeneous water sorption in a pharmaceutical formulation under controlled humidity via FT-IR imaging
Chan, K. & Kazarian, S., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 45-49 5 p.Research output: Contribution to journal › Article › peer-review
FTIR Spectroscopic Imaging of Dissolution of a Solid Dispersion of Nifedipine in Poly(ethylene glycol)
Chan, K. L. A. & Kazarian, S. G., 2004, In: Molecular Pharmaceutics. 1, 4, p. 331-335 5 p.Research output: Contribution to journal › Article › peer-review
Characterisation of bioactive and resorbable polylactide/Bioglass((R)) composites by FTIR spectroscopic imaging
Kazarian, S., Chan, K., Maquet, V. & Boccaccini, A., Aug 2004, In: Biomaterials. 25, 18, p. 3931-3938 8 p.Research output: Contribution to journal › Article › peer-review
FT-IR imaging of solvent-induced crystallization in polymers
Gupper, A., Chan, K. & Kazarian, S., 24 Aug 2004, In: MACROMOLECULES. 37, 17, p. 6498-6503 6 p.Research output: Contribution to journal › Article › peer-review
Fourier transform infrared imaging of human hair with a high spatial resolution without the use of a synchrotron
Chan, K., Kazarian, S., Mavraki, A. & Williams, D., Feb 2005, In: APPLIED SPECTROSCOPY. 59, 2, p. 149-155 7 p.Research output: Contribution to journal › Article › peer-review
Fourier transform infrared imaging for high-throughput analysis of pharmaceutical formulations
Chan, K. & Kazarian, S., 2005, In: JOURNAL OF COMBINATORIAL CHEMISTRY. 7, 2, p. 185-189 5 p.Research output: Contribution to journal › Article › peer-review
Spectroscopic imaging applied to drug release
Kazarian, S., Kong, K., Bajomo, M., Van der Weerd, J. & Chan, K., Jun 2005, In: FOOD AND BIOPRODUCTS PROCESSING. 83, 2, p. 127-135 9 p.Research output: Contribution to journal › Article › peer-review
Spectroscopic imaging of compacted pharmaceutical tablets
Chan, K., Elkhider, N. & Kazarian, S., Nov 2005, In: Chemical Engineering Research & Design. 83, 11, p. 1303-1310 8 p.Research output: Contribution to journal › Article › peer-review
Research

Medicines Development
The Medicines Development Research Group develops novel materials, formulations, drug delivery devices, manufacturing, analytical, and digital technologies.

Spatial Biology Network
The Spatial Biology Network is a cross-faculty research interest group that brings together researchers from various disciplines, ranging from technology development and molecular biology, to bioinformatics and clinical translational research, to explore the complexity of spatial biology.

The Multiscale Biofilm Research Hub (MBRH)
The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.

Synthetic biology and technological advancements
Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.
Project status: Ongoing
News
King's academics receive funding from the Royal Society
Early career researchers from the Faculty of Life Sciences and Medicine and the Faculty of Natural, Mathematical & Engineering Sciences have received over...

Features
5 minutes with Andrew Chan
Dr Andrew Chan is a Senior Lecturer in the School of Cancer & Pharmaceutical Sciences, where he focuses on applying and developing vibrational spectroscopy...

Non-salt based co-amorphous formulation produced by freeze-drying
Suleiman Alsalhi, M., Royall, P. G., Al-Obaidi, H., Alsalhi, A., Cilibrizzi, A. & Chan, K. L. A., 15 Oct 2023, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 645, 123404.Research output: Contribution to journal › Article › peer-review
Opto-Lipidomics of Tissues
Jensen, M., Liu, S., Stepula, E., Martella, D., Birjandi, A. A., Farrell-Dillon, K., Chan, K. L. A., Parsons, M., Chiappini, C., Chapple, S. J., Mann, G. E., Vercauteren, T., Abbate, V. & Bergholt, M. S., 2023, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Characterising the chemical and physical properties of phase-change nanodroplets
Zhang, W., Metzger, H., Vlatakis, S., Claxton, A., Carbajal, M., Fung, L. F., Mason, J., Chan, A., Pouliopoulos, A., Fleck, R., Prentice, P. & Thanou, M., 31 May 2023, In: Ultrasonics Sonochemistry. 97, 106445.Research output: Contribution to journal › Article › peer-review
Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug
Alsalhi, M. S., Royall, P. G. & Chan, K. L. A., 29 Jun 2022, In: RSC Advances. 12, 30, p. 19040-19053 14 p.Research output: Contribution to journal › Article › peer-review
Label-free study of intracellular glycogen level in Metformin and Resveratrol-treated insulin-resistant HepG2 by live-cell FTIR spectroscopy
Poonprasartporn, A. & Chan, K. L. A., 15 Sept 2022, In: Biosensors and Bioelectronics. 212, 114416.Research output: Contribution to journal › Article › peer-review
Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch
Benaouda, F., Inacio, R., Lim, C. H., Park, H., Pitcher, T., Alhnan, M. A., Aly, M. M. S., Al-jamal, K. T., Chan, K.-L., Gala, R. P., Sebastia-saez, D., Cui, L., Chen, T., Keeble, J. & Jones, S. A., 3 May 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 18, p. e2120340119 e2120340119.Research output: Contribution to journal › Article › peer-review
Illuminating host-parasite interaction at the cellular and subcellular levels with infrared microspectroscopy
Elsheikha, H. M., Al-Sandaqchi, A., Harun, M., Winterton, F., Altharawi, A., Elsaied, N. A., Stevenson, C., Nottingham, U., Mina, J., Cinque, G. & Chan, A., 1 Feb 2022, In: Cells. 11, 5, 811.Research output: Contribution to journal › Article › peer-review
Amino acid hydrotropes to increase the solubility of indomethacin and carbamazepine in aqueous solution
Alsalhi, M. S. & Chan, K. L. A., 5 Apr 2022, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 617, 121591.Research output: Contribution to journal › Article › peer-review
High throughput study of ionic liquids in controlled environments with FTIR spectroscopic imaging
Chan, A., Kazarian, S. G., Shalygin, A., Martyanov, O. & Welton, T., 1 Sept 2021, In: JOURNAL OF MOLECULAR LIQUIDS. 337, 116412.Research output: Contribution to journal › Article › peer-review
Inexpensive Portable Infrared Device to Detect and Quantify Alcohols in Hand Sanitizers for Public Health and Safety
Ng, J. K., Tay, F. H., Wray, P. S., Mohd Saberi, S. S., Ting, K. K. K., Khor, S. M. & Chan, K. L. A., 3 Nov 2021, (E-pub ahead of print) In: Analytical Chemistry. 93, 45, p. 15015–15023Research output: Contribution to journal › Article › peer-review
In vitro Fourier transform infrared spectroscopic study of the effect of glycerol on the uptake of beclomethasone dipropionate in living respiratory cells
Terakosolphan, W., Altharawi, A., Poonprasartporn, A., Harvey, R. D., Forbes, B. & Chan, K. L. A., 20 Nov 2021, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 609, 121118.Research output: Contribution to journal › Article › peer-review
Live cell ATR-FTIR spectroscopy as a novel bioanalytical tool for cell glucose metabolism research
Poonprasartporn, A. & Andrew Chan, K. L., Jun 2021, In: Biochimica et biophysica acta-Molecular cell research. 1868, 7, p. 119024 119024.Research output: Contribution to journal › Article › peer-review
In vitro growth-and encystation-inhibitory efficacies of matcha green tea and epigallocatechin gallate against acanthameoba castellanii
Dickson, A., Cooper, E., Fakae, L. B., Wang, B., Chan, K. L. A. & Elsheikha, H. M., Sept 2020, In: Pathogens. 9, 9, p. 1-15 15 p., 763.Research output: Contribution to journal › Article › peer-review
Synchrotron Photothermal Infrared Nanospectroscopy of Drug-Induced Phospholipidosis in Macrophages
Chan, K. L. A., Lekkas, I., Frogley, M., Cinque, G., Altharawi, A., Bello, G. & Dailey, L. A., 16 Jun 2020, In: Analytical Chemistry. 92, 12, p. 8097-8107 11 p.Research output: Contribution to journal › Article › peer-review
Identifying the responses from the estrogen receptor expressed MCF7 cells treated in anticancer drugs of different modes of action using live-cell FTIR spectroscopy
Altharawi, A., Rahman, M. & Chan, A., 22 May 2020, In: ACS Omega. 5, 22, p. 12698–12706 9 p., acsomega.9b04369.Research output: Contribution to journal › Article › peer-review
Tracking glycosylation in live cells using FTIR spectroscopy
Phelan, J., Altharawi, A. I. & Chan, A., May 2020, In: TALANTA. 211, 120737.Research output: Contribution to journal › Article › peer-review
Transmission Fourier Transform Infrared Spectroscopic Imaging, Mapping, and Synchrotron Scanning Microscopy with Zinc Sulfide Hemispheres on Living Mammalian Cells at Sub-Cellular Resolution
Chan, K. L. A., Altharawi, A. I., Fale, P., Song, C. L., Kazarian, S. G., Cinque, G., Untereiner, V. & Sockalingum, G. D., 1 May 2020, In: APPLIED SPECTROSCOPY. 74, 5, p. 544-552 9 p.Research output: Contribution to journal › Article › peer-review
Atmospheric microplastic deposition in an urban environment and an evaluation of transport
Wright, S. L., Ulke, J., Font Font, A. M., Chan, K. L. A. & Kelly, F. J., 31 Dec 2019, In: Environment International. 136, p. 105411 105411.Research output: Contribution to journal › Article › peer-review
Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR
Elsheikha, H. M., Elsaied, N. A., Chan, K. L. A., Brignell, C., Harun, M. S. R., Wehbe, K. & Cinquee, G., 21 May 2019, In: Analytical Methods. 11, 19, p. 2518-2530 13 p.Research output: Contribution to journal › Article › peer-review
Towards identifying the mode of action of drugs using live-cell FTIR spectroscopy
Altharawi, A., Rahman, K. M. & Chan, K. L. A., 21 Apr 2019, In: Analyst. 144, 8, p. 2725-2735 11 p.Research output: Contribution to journal › Article › peer-review
Subcellular mapping of living cells via synchrotron microFTIR and ZnS hemispheres
Chan, K. L. A., Fale, P. L. V., Atharawi, A., Wehbe, K. & Cinque, G., 1 Jan 2018, (Accepted/In press) In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY.Research output: Contribution to journal › Article › peer-review
A combined FTIR and DSC study on the bilayer-stabilising effect of electrostatic interactions in ion paired lipids
Schmid, M., Wölk, C., Giselbrecht, J., Chan, K. L. A. & Harvey, R. D., 18 May 2018, In: Colloids And Surfaces B-Biointerfaces.Research output: Contribution to journal › Article › peer-review
In-situ freeze-drying - forming amorphous solids directly within capsules: An investigation of dissolution enhancement for a poorly soluble drug
Alqurshi, A., Royall, P. G. & Chan, K. L. A., 6 Jun 2017, In: Scientific Reports. 7, 2910.Research output: Contribution to journal › Article › peer-review
Preventing damage of germanium optical material in attenuated total reflection-Fourier transform infrared (ATR-FTIR) studies of living cells
Fale, P. L. V. & Chan, K. L. A., 21 Jul 2016, In: VIBRATIONAL SPECTROSCOPY.Research output: Contribution to journal › Article › peer-review
Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells
Chan, A. & Kazarian, S. G., 29 Mar 2016, In: CHEMICAL SOCIETY REVIEWS. 45, 7, p. 1850-64 15 p.Research output: Contribution to journal › Article › peer-review
Solvent-Free Click-Mechanochemistry for the Preparation of Cancer Cell Targeting Graphene Oxide
Rubio Carrero, N., Mei, K.-C., Klippstein Martin, R., Coutinho Da Costa, P. M., Hodgins, N., Wang, J.T.-W., Festy, F., Abbate, V., Hider, R. C., Chan, K. L. A. & Al-Jamal, K. T., 17 Aug 2015, (E-pub ahead of print) In: ACS Applied Materials and Interfaces. 7, 34, p. 18920–18923Research output: Contribution to journal › Letter › peer-review
In situ Fourier transform infrared analysis of live cells' response to doxorubicin
Vieira Fale, P., Altharawi, A. & Chan, K. L. A., 1 Oct 2015, In: Biochimica et biophysica acta-Molecular cell research. 1853, 10 Part A, p. 2640-2648 9 p.Research output: Contribution to journal › Article › peer-review
Label-free optical imaging of live cells
Chan, K. L. A. & Vieira Fale, P., Jun 2015, Biophotonics for Medical Applications. Meglinski, I. (ed.). 1 ed. Woodhead Publishing Limited, p. 213-241 29 p. (Woodhead Publishing series in biomaterials; no. 82).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
A Central Neural Pathway Controlling Odor Tracking in Drosophila
Slater, G., Levy, P., Chan, K. L. A. & Larsen, C., 4 Feb 2015, In: Journal of neuroscience. 35, 5, p. 1831-1848 18 p.Research output: Contribution to journal › Article › peer-review
Label-Free in Situ Quantification of Drug in Living Cells at Micromolar Levels Using Infrared Spectroscopy
Chan, K. L. A. & Vieira Fale, P. L., 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11673-11679 7 p.Research output: Contribution to journal › Article › peer-review
FTIR Spectroscopic Study of Poly(Ethylene Glycol)–Nifedipine Dispersion Stability in Different Relative Humidities
Iqbal, W. S. & Chan, K. L. A., Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 1, p. 280-284 5 p.Research output: Contribution to journal › Article › peer-review
Dissolution of solid dispersions of ibuprofen studied by Fourier transform infrared imaging
Chan, K. & Kazarian, S., 2006, WASHINGTON: AMER CHEMICAL SOC. 12 p. (ACS SYMPOSIUM SERIES; vol. 924)Research output: Book/Report › Book
Combined application of imaging methods for the characterization of a polymer blend
Gupper, A., Wilhelm, P., Schmied, M., Kazarian, S., Chan, K. & Reussner, J., Dec 2002, In: APPLIED SPECTROSCOPY. 56, 12, p. 1515-1523 9 p.Research output: Contribution to journal › Article › peer-review
Confocal Raman microscopy of supercritical fluid dyeing of polymers
Kazarian, S. & Chan, K., 2003, In: Analyst. 128, 5, p. 499-503 5 p.Research output: Contribution to journal › Article › peer-review
New opportunities in micro- and macro-attenuated total reflection infrared spectroscopic imaging: Spatial resolution and sampling versatility
Chan, K. & Kazarian, S., Apr 2003, In: APPLIED SPECTROSCOPY. 57, 4, p. 381-389 9 p.Research output: Contribution to journal › Article › peer-review
Applications of attenuated total reflection infrared spectroscopic imaging to pharmaceutical formulations
Chan, K., Hammond, S. & Kazarian, S., 1 May 2003, In: Analytical Chemistry. 75, 9, p. 2140-2146 7 p.Research output: Contribution to journal › Article › peer-review
"Chemical photography" of drug release
Kazarian, S. & Chan, K., 30 Dec 2003, In: MACROMOLECULES. 36, 26, p. 9866-9872 7 p.Research output: Contribution to journal › Article › peer-review
FTIR imaging of polymeric materials under high-pressure carbon dioxide
Kazarian, S. & Chan, K., 27 Jan 2004, In: MACROMOLECULES. 37, 2, p. 579-584 6 p.Research output: Contribution to journal › Article › peer-review
Polymorphism and devitrification of nifedipine under controlled humidity: a combined FT-Raman, IR and Raman microscopic investigation
Chan, K., Fleming, O., Kazarian, S., Vassou, D., Chryssikos, G. & Gionis, V., May 2004, In: JOURNAL OF RAMAN SPECTROSCOPY. 35, 5, p. 353-359 7 p.Research output: Contribution to journal › Article › peer-review
FT-IR imaging and Raman microscopic study of poly(ethylene terephthalate) film processed with supercritical CO2
Fleming, O., Chan, K. & Kazarian, S., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 3-7 5 p.Research output: Contribution to journal › Article › peer-review
Water vapour-induced mesoporous structure collapse observed by VGI and FT-IR spectroscopy
Jervis, H., Kazarian, S., Chan, K., Bruce, D. & King, N., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 225-231 7 p.Research output: Contribution to journal › Article › peer-review
An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution
van der Weerd, J., Chan, K. & Kazarian, S., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 9-13 5 p.Research output: Contribution to journal › Article › peer-review
Visualisation of the heterogeneous water sorption in a pharmaceutical formulation under controlled humidity via FT-IR imaging
Chan, K. & Kazarian, S., 17 Jun 2004, In: VIBRATIONAL SPECTROSCOPY. 35, 1-2, p. 45-49 5 p.Research output: Contribution to journal › Article › peer-review
FTIR Spectroscopic Imaging of Dissolution of a Solid Dispersion of Nifedipine in Poly(ethylene glycol)
Chan, K. L. A. & Kazarian, S. G., 2004, In: Molecular Pharmaceutics. 1, 4, p. 331-335 5 p.Research output: Contribution to journal › Article › peer-review
Characterisation of bioactive and resorbable polylactide/Bioglass((R)) composites by FTIR spectroscopic imaging
Kazarian, S., Chan, K., Maquet, V. & Boccaccini, A., Aug 2004, In: Biomaterials. 25, 18, p. 3931-3938 8 p.Research output: Contribution to journal › Article › peer-review
FT-IR imaging of solvent-induced crystallization in polymers
Gupper, A., Chan, K. & Kazarian, S., 24 Aug 2004, In: MACROMOLECULES. 37, 17, p. 6498-6503 6 p.Research output: Contribution to journal › Article › peer-review
Fourier transform infrared imaging of human hair with a high spatial resolution without the use of a synchrotron
Chan, K., Kazarian, S., Mavraki, A. & Williams, D., Feb 2005, In: APPLIED SPECTROSCOPY. 59, 2, p. 149-155 7 p.Research output: Contribution to journal › Article › peer-review
Fourier transform infrared imaging for high-throughput analysis of pharmaceutical formulations
Chan, K. & Kazarian, S., 2005, In: JOURNAL OF COMBINATORIAL CHEMISTRY. 7, 2, p. 185-189 5 p.Research output: Contribution to journal › Article › peer-review
Spectroscopic imaging applied to drug release
Kazarian, S., Kong, K., Bajomo, M., Van der Weerd, J. & Chan, K., Jun 2005, In: FOOD AND BIOPRODUCTS PROCESSING. 83, 2, p. 127-135 9 p.Research output: Contribution to journal › Article › peer-review
Spectroscopic imaging of compacted pharmaceutical tablets
Chan, K., Elkhider, N. & Kazarian, S., Nov 2005, In: Chemical Engineering Research & Design. 83, 11, p. 1303-1310 8 p.Research output: Contribution to journal › Article › peer-review
Research

Medicines Development
The Medicines Development Research Group develops novel materials, formulations, drug delivery devices, manufacturing, analytical, and digital technologies.

Spatial Biology Network
The Spatial Biology Network is a cross-faculty research interest group that brings together researchers from various disciplines, ranging from technology development and molecular biology, to bioinformatics and clinical translational research, to explore the complexity of spatial biology.

The Multiscale Biofilm Research Hub (MBRH)
The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.

Synthetic biology and technological advancements
Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.
Project status: Ongoing
News
King's academics receive funding from the Royal Society
Early career researchers from the Faculty of Life Sciences and Medicine and the Faculty of Natural, Mathematical & Engineering Sciences have received over...

Features
5 minutes with Andrew Chan
Dr Andrew Chan is a Senior Lecturer in the School of Cancer & Pharmaceutical Sciences, where he focuses on applying and developing vibrational spectroscopy...
