Jennifer Joslin is a PhD Student in the Department of Inflammation Biology, which sits within the School of Immunology & Microbial Sciences in the Faculty of Life Sciences & Medicine.

PhD title: Assessment of endothelial glycocalyx dysfunction and impaired microcirculatory perfusion during cardiac surgery to improve prediction of post-operative acute kidney injury and understanding of pathophysiological mechanisms.

For her PhD, Jen has completed a clinical study demonstrating increased shedding of Syndecan-1, a core endothelial glycocalyx constituent, in patients undergoing cardiac surgery who go on to develop post-operative acute kidney injury. She is using sublingual incident dark field microscopy to explore intra-operative microvascular perfusion. In the lab Jen is working on assessing endothelial glycocalyx degradation in cultured cells (HUVECs and ciGEnCs) in response to serum from clinical study participants, and has used a focussed proteomics approach to explore potential differences between participants with high and low shedding.

PURE profile: https://kclpure.kcl.ac.uk/portal/en/persons/jennifer.joslin