Dr James Garnett
Reader in Microbial Structural Biology
Biography
Dr Garnett is a Reader in Microbial Structural Biology in the Centre for Host-Microbiome Interactions.
A major focus of his work has been understanding the molecular mechanisms that promote disease using structural biology coupled with microbiology, biochemistry, and biophysical techniques.
He gained his PhD from the Astbury Centre for Structural and Molecular Biology at the University of Leeds where he studied transcriptional regulation of L-arginine metabolism in bacteria. After his PhD he remained in Leeds working towards the development of new antibacterial compounds directed against peptidoglycan biosynthesis. He then moved to Imperial College London, where he studied important and novel virulence mechanisms used by bacteria, fungi, and protozoa. After receiving an MRC new investigator award, he moved to Queen Mary University of London in 2015 to setup his research group and to study mechanisms of type II secretion in Legionella pneumophila. He started at King’s in 2019 as a Senior Lecturer and become a Reader in 2022.
Research
Garnett Lab
The Garnett Lab investigates molecular mechanisms that promote bacterial disease. In particular we are interested in biofilm formation and other key virulence traits that allow bacteria to establish infections and persist within the host/environment.
The Multiscale Biofilm Research Hub (MBRH)
The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.
Biofilms at mucosal surfaces
The study of dental caries, periodontitis, vaginal dysbiosis, chronic inflammatory diseases & infections within the oral cavity, intestinal tract & lungs
Project status: Ongoing
Antimicrobial resistance and biofilm therapeutics
Work involves understanding how biofilms contribute to antimicrobial resistance and the creation of new anti-biofilm therapeutics.
Project status: Ongoing
Synthetic biology and technological advancements
Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.
Project status: Ongoing
Microbes in Health & Disease
The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.
Research
Garnett Lab
The Garnett Lab investigates molecular mechanisms that promote bacterial disease. In particular we are interested in biofilm formation and other key virulence traits that allow bacteria to establish infections and persist within the host/environment.
The Multiscale Biofilm Research Hub (MBRH)
The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.
Biofilms at mucosal surfaces
The study of dental caries, periodontitis, vaginal dysbiosis, chronic inflammatory diseases & infections within the oral cavity, intestinal tract & lungs
Project status: Ongoing
Antimicrobial resistance and biofilm therapeutics
Work involves understanding how biofilms contribute to antimicrobial resistance and the creation of new anti-biofilm therapeutics.
Project status: Ongoing
Synthetic biology and technological advancements
Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.
Project status: Ongoing
Microbes in Health & Disease
The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.