Dr Antoni Borysik is a Senior Lecturer in the Department of Chemistry, King's College London. He has more than 20 years experience developing applications for biomolecular characterisation using mass spectrometry. He joined King’s in 2014 from the University of Oxford where he was a industrial fellow with Waters Corporation developing methods to probe the solvent-free behavior of membrane proteins and disordered proteins using travelling wave ion mobility and molecular dynamics simulations. He obtained his PhD at the University of Leeds where he pioneered methods to characterise the folding of amyloidogenic proteins with mass spectrometry. 

Research Interests

• Mass spectrometry
• Hydrogen deuterium exchange
• Protein modelling
• Intrinsic disorder

Teaching

• General Chemistry
• Advanced Analytical Chemistry
• UG Research Methods Literature Review
• MSci Research Project & Dissertation
• MRes Expanding the Frontiers of Chemistry
• MRes Research Project in Interdisciplinary Chemistry

Research profile

For more information on Dr Borysik's research please see his Research Portal page

The Borysik Group

Postgraduate Researchers

• Chloe Bailey
• Sabrina Hossain
• Alexandros Gkounta

The Borysik Group use native mass spectrometry (MS) ion mobility MS and hydrogen-deuterium exchange MS (HDX-MS) to study the conformations and dynamics of important biomolecules in order to understand their function. Current projects involve natively unfolded proteins including those involved in liquid-liquid phase separation and proteins implicated in protein deposition disorders. The Borysik Group also develops advanced computational techniques for HDX-MS including HDXmodeller for quantitative high-resolution HDX-MS. The Borysik group is also interested in methods for structural determination using MS and applications of artificial intelligence in for HDX-MS.