My lab focuses on combining bioengineering, stem cell technologies and neuroscience to create complex models of the nervous system. We use these modelling platform to both discover new fundamental mechanisms in neurobiology, and to better understand the molecular chains of event that lead to neurodegeneration. Our interdisciplinary team focuses on a range of projects that seek to uncover the "engineering principles" of neurons, glia and complex circuitry, both to uncover new fundamental knowledge and to create new tools to model neural circuitry in vitro.

Please see my Research Staff Profile for more detail

 

 

 

Find out more about my research:

The Serio Lab

 

 

Key Publications:

• Hagemann et al., 2022. Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform. Advanced Healthcare Materials. 
• Harley et al., 2021. TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain. Brain Communications.
• Bergholt et al., 2018. Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis. ACS Central Science.
• Serio et al., 2013. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. PNAS.
  
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Key Collaborators

• Prof Jernej Ule, King's College London
• Prof Rickie Patani, UCL
• Prof Giampietro Schiavo, UCL
• Prof Francesco Saverio Tedesco, UCL