Biography
I am a Research Associate, funded by the NIHR Maudsley Biomedical Research Centre, within Professor Cathryn Lewis’s team at the Social, Genetic and Developmental Psychiatry Centre. I am interested in using statistics to understand and predict outcomes relevant to mental health.
My background is in biostatistics and statistical genetics. I studied Mathematics with Economics (BSc, University of Sussex), and Biostatistics (MSc, University of New South Wales), before working as a Research Assistant across multiple projects including: the development of log-linear regression methods, analysing GO gameplay data and modelling fetal growth trajectories. I completed a PhD in Statistical Genetics from King’s College London, where I developed and applied methods for scale transformations and genetic risk prediction using summary statistics, and characterised subtypes of Amyotrophic Lateral Sclerosis using model-based clustering.
My current project investigates the impact of depression, and depression polygenic scores, on glycaemic control for individuals with Type 2 Diabetes.
Research interests:
- Longitudinal data analysis
- Polygenic scores
- Prediction modelling
- Depression and mental health
Research groups:
- Statistical genetics unit lead by Professor Cathryn Lewis.
Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank
Kamp, M., Lo, C., Kokkinidis, G., Chauhan, M., Gillett, A., Pain, O., M. McIntosh, A. & Lewis, C., 12 Mar 2025, In: Psychological Medicine.Research output: Contribution to journal › Article › peer-review
What’s UPDOG? A novel tool for trans-ancestral polygenic score prediction
Howard, D., Pain, O., Gillett, A., Vassos, E. & Lewis, C., 16 May 2024, In: Wellcome Open Research. p. 275 9.Research output: Contribution to journal › Article
Exploring polygenic-environment and residual-environment interactions for depressive symptoms within the UK Biobank
Gillett, A. C., Jermy, B. S., Lee, S. H., Pain, O., Howard, D. M., Hagenaars, S. P., Hanscombe, K. B., Coleman, J. R. I. & Lewis, C. M., 1 Jul 2022, In: Genetic Epidemiology. 46, 5-6, p. 219-233 15 p.Research output: Contribution to journal › Article › peer-review
A Tool for Translating Polygenic Scores onto the Absolute Scale Using Summary Statistics
Pain, O., Gillett, A., Austin, J., Folkersen, L. & Lewis, C., 9 Dec 2021, (Accepted/In press) In: European Journal of Human Genetics.Research output: Contribution to journal › Article › peer-review
Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts
Arathimos, R., Fabbri, C., Vassos, E., Davis, K., Pain, O., Gillett, A., Coleman, J., Hanscombe, K., Hagenaars, S., Jermy, B., Corbett, A., Ballard, C., Aarsland, D., Creese, B. & Lewis, C., 16 Nov 2021, (Accepted/In press) In: British Journal of Psychiatry.Research output: Contribution to journal › Article › peer-review
Reproductive fitness and genetic risk of psychiatric disorders in the general population
Mullins, N., Ingason, A., Porter, H., Euesden, J., Gillett, A., Ólafsson, S., Gudbjartsson, D. F., Lewis, C. M., Sigurdsson, E., Saemundsen, E., Gudmundsson, Ó., Frigge, M. L., Kong, A., Helgason, A., Walters, G. B., Gustafsson, O., Stefansson, H. & Stefansson, K., 13 Jun 2017, In: Nature Communications. 8, 15833.Research output: Contribution to journal › Article › peer-review
Transforming Summary Statistics from Logistic Regression to the Liability Scale: Application to Genetic and Environmental Risk Scores
Gillett, A. C., Vassos, E. & Lewis, C. M., 13 Mar 2019, (E-pub ahead of print) In: Human Heredity. 83, 4, p. 210-224 15 p.Research output: Contribution to journal › Article › peer-review
Clinical, ultrasound and molecular biomarkers for early prediction of large for gestational age infants in nulliparous women: An international prospective cohort study
Vieira, M. C., McCowan, L. M. E., Gillett, A., Poston, L., Fyfe, E., Dekker, G. A., Baker, P. N., Walker, J. J., Kenny, L. C., Pasupathy, D. & SCOPE Consortium, 1 Jun 2017, In: PloS one. 12, 6, p. e0178484Research output: Contribution to journal › Article › peer-review
Clinical and biochemical factors associated with preeclampsia in women with obesity
Costa Vieira, M., Poston, L., Fyfe, E., Gillett, A., Kenny, L. C., Roberts, C. T., Baker, P. N., Myers, J. E., Walker, J. J., Mccowan, L. M., North, R. A. & Pasupathy, D., 23 Dec 2016, (E-pub ahead of print) In: Obesity.Research output: Contribution to journal › Article › peer-review
Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis
Gaastra, B., Shatunov, A., Pulit, S., Jones, A. R., Sproviero, W., Gillett, A., Chen, Z., Kirby, J., Fogh, I., Powell, J. F., Leigh, P. N., Morrison, K. E., Shaw, P. J., Shaw, C. E., van den Berg, L. H., Veldink, J. H., Lewis, C. M. & Al-Chalabi, A., 2 Sept 2016, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 17, 7-8, p. 593-599 7 p.Research output: Contribution to journal › Article › peer-review
Research
The Statistical Genetics Unit
Led by Professor Cathryn Lewis, it is a cross-school unit, comprising 20 researchers in the Social, Genetic & Developmental Psychiatry Centre and in the Department of Medical and Molecular Genetics. Our aims are to develop and apply statistical methods to identify and characterise the genetic component to common, complex disorders.
Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank
Kamp, M., Lo, C., Kokkinidis, G., Chauhan, M., Gillett, A., Pain, O., M. McIntosh, A. & Lewis, C., 12 Mar 2025, In: Psychological Medicine.Research output: Contribution to journal › Article › peer-review
What’s UPDOG? A novel tool for trans-ancestral polygenic score prediction
Howard, D., Pain, O., Gillett, A., Vassos, E. & Lewis, C., 16 May 2024, In: Wellcome Open Research. p. 275 9.Research output: Contribution to journal › Article
Exploring polygenic-environment and residual-environment interactions for depressive symptoms within the UK Biobank
Gillett, A. C., Jermy, B. S., Lee, S. H., Pain, O., Howard, D. M., Hagenaars, S. P., Hanscombe, K. B., Coleman, J. R. I. & Lewis, C. M., 1 Jul 2022, In: Genetic Epidemiology. 46, 5-6, p. 219-233 15 p.Research output: Contribution to journal › Article › peer-review
A Tool for Translating Polygenic Scores onto the Absolute Scale Using Summary Statistics
Pain, O., Gillett, A., Austin, J., Folkersen, L. & Lewis, C., 9 Dec 2021, (Accepted/In press) In: European Journal of Human Genetics.Research output: Contribution to journal › Article › peer-review
Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts
Arathimos, R., Fabbri, C., Vassos, E., Davis, K., Pain, O., Gillett, A., Coleman, J., Hanscombe, K., Hagenaars, S., Jermy, B., Corbett, A., Ballard, C., Aarsland, D., Creese, B. & Lewis, C., 16 Nov 2021, (Accepted/In press) In: British Journal of Psychiatry.Research output: Contribution to journal › Article › peer-review
Reproductive fitness and genetic risk of psychiatric disorders in the general population
Mullins, N., Ingason, A., Porter, H., Euesden, J., Gillett, A., Ólafsson, S., Gudbjartsson, D. F., Lewis, C. M., Sigurdsson, E., Saemundsen, E., Gudmundsson, Ó., Frigge, M. L., Kong, A., Helgason, A., Walters, G. B., Gustafsson, O., Stefansson, H. & Stefansson, K., 13 Jun 2017, In: Nature Communications. 8, 15833.Research output: Contribution to journal › Article › peer-review
Transforming Summary Statistics from Logistic Regression to the Liability Scale: Application to Genetic and Environmental Risk Scores
Gillett, A. C., Vassos, E. & Lewis, C. M., 13 Mar 2019, (E-pub ahead of print) In: Human Heredity. 83, 4, p. 210-224 15 p.Research output: Contribution to journal › Article › peer-review
Clinical, ultrasound and molecular biomarkers for early prediction of large for gestational age infants in nulliparous women: An international prospective cohort study
Vieira, M. C., McCowan, L. M. E., Gillett, A., Poston, L., Fyfe, E., Dekker, G. A., Baker, P. N., Walker, J. J., Kenny, L. C., Pasupathy, D. & SCOPE Consortium, 1 Jun 2017, In: PloS one. 12, 6, p. e0178484Research output: Contribution to journal › Article › peer-review
Clinical and biochemical factors associated with preeclampsia in women with obesity
Costa Vieira, M., Poston, L., Fyfe, E., Gillett, A., Kenny, L. C., Roberts, C. T., Baker, P. N., Myers, J. E., Walker, J. J., Mccowan, L. M., North, R. A. & Pasupathy, D., 23 Dec 2016, (E-pub ahead of print) In: Obesity.Research output: Contribution to journal › Article › peer-review
Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis
Gaastra, B., Shatunov, A., Pulit, S., Jones, A. R., Sproviero, W., Gillett, A., Chen, Z., Kirby, J., Fogh, I., Powell, J. F., Leigh, P. N., Morrison, K. E., Shaw, P. J., Shaw, C. E., van den Berg, L. H., Veldink, J. H., Lewis, C. M. & Al-Chalabi, A., 2 Sept 2016, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 17, 7-8, p. 593-599 7 p.Research output: Contribution to journal › Article › peer-review
Research
The Statistical Genetics Unit
Led by Professor Cathryn Lewis, it is a cross-school unit, comprising 20 researchers in the Social, Genetic & Developmental Psychiatry Centre and in the Department of Medical and Molecular Genetics. Our aims are to develop and apply statistical methods to identify and characterise the genetic component to common, complex disorders.