King's College London

View our latest research outputs in full on our Pure page.

Recent publications include:

The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans Rehman, S., Antonovic, A. K., McIntire, I. E., Zheng, H., Cleaver, L., Baczynska, M., Adams, C. O., Portlock, T., Richardson, K., Shaw, R., Oregioni, A., Mastroianni, G., Whittaker, S. B. M., Kelly, G., Lorenz, C. D., Fornili, A., Cianciotto, N. P. & Garnett, J. A., Dec 2024, In: Nat Commun. 15, 1, 4912.
Research output: Contribution to journal › Article › peer-review

The crucial role of bioimage analysts in scientific research and publication Cimini, B. A., Bankhead, P., D'Antuono, R., Fazeli, E., Fernandez-Rodriguez, J., Fuster-Barcelò, C., Haase, R., Jambor, H. K., Jones, M. L., Jug, F., Klemm, A. H., Kreshuk, A., Marcotti, S., Martins, G. G., McArdle, S., Miura, K., Munoz-Barrutia, A., Murphy, L. C., Nelson, M. S., Norrelykke, S. F., & 13 othersPaul-Gilloteaux, P., Pengo, T., Pylvänäinen, J. W., Pytowski, L., Ravera, A., Reinke, A., Rekik, Y., Strambio-De-Castillia, C., Thédié, D., Uhlmann, V., Umney, O., Wiggins, L. & Eliceiri, K. W., 30 Oct 2024, In: Journal of cell science. 137, 20
Research output: Contribution to journal › Article › peer-review

King’s College London Centre for Biomolecular Spectroscopy (CBS) Symposium. 7 June 2024, London, UK Prischi, F., Jarvis, J. & Conte, M. R., 18 Oct 2024, p. 45. 1 p.
Research output: Contribution to conference types › Other

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons Sleigh, J. N., Mattedi, F., Richter, S., Annuario, E., Ng, K., Steinmark, I. E., Ivanova, I., Darabán, I. L., Joshi, P. P., Rhymes, E. R., Awale, S., Yahioglu, G., Mitchell, J. C., Suhling, K., Schiavo, G. & Vagnoni, A., Oct 2024, In: AGING CELL. 23, 10, e14250.
Research output: Contribution to journal › Article › peer-review

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation Ocasio, C. A., Baggelaar, M. P., Sipthorp, J., Losada de la Lastra, A., Tavares, M., Volarić, J., Soudy, C., Storck, E. M., Houghton, J. W., Palma-Duran, S. A., MacRae, J. I., Tomić, G., Carr, L., Downward, J., Eggert, U. S. & Tate, E. W., Oct 2024, In: Nature Biotechnology. 42, 10, p. 1548-1558 11 p.
Research output: Contribution to journal › Article › peer-review

Stellabody: A novel hexamer-promoting mutation for improved IgG potency Whitehead, C., Wines, B., Davies, A. M., McDonnell, J., Trist, H., Esparon, S. & Hogarth, P. M., 4 Oct 2024, In: Immunological Reviews.
Research output: Contribution to journal › Review article › peer-review

Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate Keratinocyte Adhesion and Migration Bare, Y., Chan, G. K., Hayday, T., McGrath, J. A. & Parsons, M., 30 Sept 2024, In: Journal of Investigative Dermatology. 141, 3, p. 523-532.e2
Research output: Contribution to journal › Article › peer-review

DrugSynthMC: An Atom-Based Generation of Drug-like Molecules with Monte Carlo Search Roucairol, M., Georgiou, A., Cazenave, T., Prischi, F. & Pardo, O. E., 23 Sept 2024, In: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 64, 18, p. 7097-7107 11 p.
Research output: Contribution to journal › Article › peer-review

Enhancing Research Through Image Analysis Workshops: Experiences and Best Practices Marcotti, S., Jones, M. L., Slater, T. J. A. & Barry, D. J., 23 Sept 2024, Microscopy Research and Technique.
Research output: Working paper/Preprint › Preprint

Injectable PEG Hydrogels with Tissue‐Like Viscoelasticity Formed through Reversible Alendronate–Calcium Phosphate Crosslinking for Cell–Material Interactions Yu, H., Yan, Z., Dreiss, C. A., Gaitano, G. G., Jarvis, J. A., Gentleman, E., Da silva, R. M. P. & Grigoriadis, A. E., 1 Sept 2024, In: Advanced Healthcare Materials. 13, 22, 2400472.
Research output: Contribution to journal › Article › peer-review

Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis Chander, A., Iacovacci, J., Pellon, A., Kataria, R., Grigoriadis, A., Maher, J., Sears, C., Bachrach, G., Urbano, T. G., Lei, M., Petkar, I., Kong, A., Ng, T., Orlandi, E., Iacovelli, N. A., De Cecco, L., Serafini, M. S., Moyes, D., Rancati, T. & Ferreira, M. R., Aug 2024, In: Cancer Communications. 44, 8, p. 879-883 5 p.
Research output: Contribution to journal › Letter › peer-review

Horizontal gene transfer-initiated reorganization of lipid metabolism drives lifestyle innovation in a eukaryote Rao, B., Gomez Gil, E., Peter, M., Balogh, G., Nunes, V., MacRae, J., Chen, Q., Rosenthal, P. & Oliferenko, S., 21 Aug 2024.
Research output: Working paper/Preprint › Preprint

Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia. Murphy, G. R. F., Feneck, E., Paget, J., Sivakumar, B., Smith, G. & Logan, M. P. O., Aug 2024, In: Journal of Anatomy. 245, 2, p. 217-230 14 p.

Defining and modelling dynamic spatial heterogeneity within tumor microenvironments. Bareham, B., Dibble, M. & Parsons, M., 8 Aug 2024, (Accepted/In press) In: Current Opinion in Cell Biology.

IgE glycosylation and impact on structure and function: A systematic review. McCraw, A. J., Palhares, L. C. G. F., Hendel, J. L., Gardner, R. A., Santaolalla, A., Crescioli, S., McDonnell, J., Van Hemelrijck, M., Chenoweth, A., Spencer, D. I. R., Wagner, G. K. & Karagiannis, S. N., 4 Aug 2024, In: Allergy.

Structural anisotropy results in mechano-directional transport of proteins across nuclear pores. Panagaki, F., Tapia-Rojo, R., Zhu, T., Milmoe, N., Paracuellos, P., Board, S., Mora, M., Walker, J., Rostkova, E., Stannard, A., Infante, E. & Garcia-Manyes, S., Jul 2024, In: Nature Physics. 20, 7, p. 1180-1193 14 p.

Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment. Leech, V., Kenny, F., Marcotti, S., Shaw, T., Stramer, B. & Manhart, A., 29 Jul 2024, In: PLoS Computational Biology. 20, 7 JULY, e1011879.

Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development. Horton, S., Mastrolia, V., Jackson, R. E., Kemlo, S., Pereira Machado, P. M., Carbajal, M. A., Hindges, R., Fleck, R. A., Aguiar, P., Neves, G. & Burrone, J., 23 Jul 2024, In: Cell Reports. 43, 7, 114361.

The MondoA-dependent TXNIP/GDF15 1 axis predicts oxaliplatin response in colorectal adenocarcinomas. Oxaliplatin-induced immunogenicity through the regulation of the TXNIP/GDF15 axis. Deng, J., Pan, T., Wang, D., Hong, Y., Liu, Z., Zhou, X., An, Z., Li, L., Alfano, G., Li, G., Dolcetti, L., Evans, R., Vicencio Bustamante, J., Vlckova, P., Chen, Y., Monypenny of Pitmilly, J., Araujo De Carvalho Gomes, C., Weitsman, G., Ng, K., McCarthy, C., & 11 others, 3 Jul 2024, (Accepted/In press) In: EMBO Molecular Medicine.

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons. Sleigh, J. N., Mattedi, F., Richter, S., Annuario, E., Ng, K., Steinmark, I. E., Ivanova, I., Darabán, I. L., Joshi, P. P., Rhymes, E. R., Awale, S., Yahioglu, G., Mitchell, J. C., Suhling, K., Schiavo, G. & Vagnoni, A., 17 Jun 2024, (E-pub ahead of print) In: AGING CELL.

Energy Landscapes and Structural Ensembles of Glucagon-like Peptide-1 Monomers. Keith, A. D., Brichtová, E. P., Barber, J. G., Wales, D. J., Jackson, S. E. & Röder, K., 13 Jun 2024, In: The journal of physical chemistry. B. 128, 23, p. 5601-5611 11 p.

Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection. Wang, C., Gu, C., Popp, C., Vashisth, P., Mustfa, S. A., Martella, D. A., Spiteri, C., McLennan, S., Sun, N., Riddle, M., Eide, C. R., Parsons, M., Tolar, J., McGrath, J. A. & Chiappini, C., 11 Jun 2024, In: ACS Nano. 18, 23, p. 14938-14953 16 p.

Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere. Li, C., Warren, D. T., Zhou, C., De Silva, S., Wilson, D., Garcia Maya, M., Wheeler, M., Meinke, P., Sawyer, G., Ehler, E., Wehnert, M., Rao, L., Zhang, Q. & Shanahan, C., May 2024, In: Journal of Biological Chemistry. 300, 5, 107254.

DrugSynthMC: an atom based generation of drug-like molecules with Monte Carlo Search. Roucairol, M., Georgiou, A., Cazenave, T., Prischi, F. & Pardo, O., 29 May 2024.

FRET Sensor-Modified Synthetic Hydrogels for Real-Time Monitoring of Cell-Derived Matrix Metalloproteinase Activity using Fluorescence Lifetime Imaging. Yan, Z., Kavanagh, T., da Silva Harrabi, R., Lust, S., Tang, C., Beavil, R., Mueller, M. M., Beavil, A., Ameer-Beg, S., M. P. da Silva, R. & Gentleman, E., 22 May 2024, In: Advanced Functional Materials. 34, 21, 2309711.

Transcriptomic gene signatures measure satellite cell activity in muscular dystrophies. Engquist, E., Greco, A., Joosten, L. A., van Engelen, B. G. M., Banerji, C. & Zammit, P., 6 May 2024, In: iScience.

Characterisation and correction of polarisation effects in fluorescently labelled fibres. Aggarwal, N., Marsh, R., Marcotti, S., Shaw, T., Stramer, B., Cox, S. & Culley, S., 29 Apr 2024, In: Journal of Microscopy.

N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling. Kliza, K. W., Song, W., Pinzuti, I., Schaubeck, S., Kunzelmann, S., Kuntin, D., Fornili, A., Pandini, A., Hofmann, K., Garnett, J. A., Stieglitz, B. & Husnjak, K., 20 Apr 2024, In: Cell Death Discovery. 10, 1, 183.

The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis. Grigoriadis, A., Conte, M. R., Coleman, J., Tattersall, L., Yianni, V., Knight, L., Yu, H., Hallett, S., Johnson, P., Caetano, A., Cosstick, C., Ridley, A. & Gartland, A., 19 Apr 2024, In: iScience. 27, 4, 109288.

Cellular Imaging and Time-Domain FLIM Studies of Meso-Tetraphenylporphine Disulfonate as a Photosensitising Agent in 2D and 3D Models. Balukova, A., Bokea, K., Barber, P. R., Ameer-Beg, S. M., MacRobert, A. J. & Yaghini, E., 11 Apr 2024, In: International Journal of Molecular Sciences. 25, 8, 4222.

Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion. Bagley, D., Russell, T., Ortiz-Zapater, E., Stinson, S., Fox, K., Redd, P., Joseph, M., Deering-Rice, C., Reilly, C., Parsons, M., Brightling, C. & Rosenblatt, J., 4 Apr 2024, In: Science. 384, 6691, p. 66-73 8 p., 6691.

Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists. Kondacs, L., Parijat, P., Cobb, A. J. A. & Kampourakis, T., 14 Mar 2024, In: Acs Medicinal Chemistry Letters. 15, 3, p. 413-417

Development of widefield time-resolved fluorescence anisotropy imaging (TR-FAIM) using a single photon avalanche diode (SPAD) array. Mogridge, L. O., Nedbal, J., Awale, S., Tallis, J., Johnston, E. J., Della Rocca, F. M., Rosser, S. J., Henderson, R. K. & Suhling, K., 12 Mar 2024, In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE.

Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales. Tapia Rojo, R., Mora Hortal, M. & Garcia-Manyes, S., 11 Mar 2024, In: Nature Protocols. 19, 6, p. 1779–1806 28 p., 19.

The p90 Ribosomal S6 Kinases 2 and 4 promote Prostate Cancer cell proliferation in androgen-dependent and independent ways. Cronin, R., Azadova, A., Marco, A., Laissue, P., Brooke, G. N. & Prischi, F., 6 Mar 2024.

Multimodal bioimaging across disciplines and scales: challenges, opportunities and breaking down barriers. Bischof, J., Fletcher, G., Verkade, P., Kuntner, C., Fernandez-Rodriguez, J., Chaabane, L., Rose, L. A., Walter, A., Vandenbosch, M., van Zandvoort, M. A. M. J., Zaritsky, A., Keppler, A. & Parsons, M., 1 Mar 2024, In: npj Imaging.

Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin. Weston, T. G. R., Rees, M., Gautel, M. & Fraternali, F., 1 Mar 2024, In: WIREs Mechanisms of Disease. 16, 2, e1638.

Schizosaccharomyces versatilis represents a distinct evolutionary lineage of fission yeast. Etherington, G. J., Gil, E. G., Haerty, W., Oliferenko, S. & Nieduszynski, C. A., Mar 2024, In: Yeast. 41, 3, p. 95-107 13 p.

Telomere-to-telomere Schizosaccharomyces japonicus genome assembly reveals hitherto unknown genome features. Etherington, G. J., Wu, P. S., Oliferenko, S., Uhlmann, F. & Nieduszynski, C. A., Mar 2024, In: Yeast. 41, 3, p. 73-86 14 p.