King's College London

New King’s College London research – funded by the Medical Research Foundation and published today in Translational Psychiatry - reveals how subtle differences in brain connectivity could offer a sign of risk for postpartum psychosis in women.

Postpartum psychosis is a devastating, but rare, mental health problem that affects women in the first few weeks after giving birth. Symptoms vary widely, and can include high mood (mania), depression, confusion, hallucinations and delusions.

Although the disorder affects only one in every 1,000 women who have a baby, it is much more common in mothers with a history of bipolar disorder or schizoaffective disorder (a condition which has symptoms of schizophrenia and bipolar disorder), or women who have suffered a previous episode of postpartum psychosis.

There are currently no biological markers that help to identify women who could go on to develop postpartum psychosis, and the role of brain connectivity – how different areas of the brain talk to each other, measured using brain scans – is yet to be fully explored.

Researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, and the University of Padova in Italy, found that compared with healthy women, women at risk of postpartum psychosis show altered connectivity in brain networks associated with ‘goal-directed behaviour’ – i.e. areas of the brain involved in planning, organising and completing short and long-term tasks.

Their study also offers the first evidence that increased connectivity within the brain’s executive network (responsible for attention, working memory and decision-making) could represent a marker of resilience to postpartum psychosis relapse.

32 women ‘at risk’ of postpartum psychosis, and 27 healthy women, were followed up from pregnancy through to eight weeks after giving birth. They were considered ‘at risk’ of postpartum psychosis if they had a diagnosis of bipolar disorder or schizoaffective disorder, or if they had suffered a previous episode of postpartum psychosis. In the first four weeks after delivery, 15 women became unwell with symptoms indicating postpartum psychosis.

Eight weeks after giving birth, the women had brain scans while resting, followed by further scans during an emotional processing task, to study how different brain areas were activated, and the interplay between them. For the task, participants looked at images of faces expressing different emotions and had to identify that emotion (for example, a face showing a fearful expression). The researchers measured how long it took for them to successfully identify these emotions and analysed how different networks of the brain were activated.

All women at risk of postpartum psychosis, and particularly those who later became unwell, struggled more with understanding and decoding negative emotions, compared to the healthy women. This was indicated by reduced connectivity between certain brain networks during the task, and longer reaction times to the negative emotional images.

While similar connectivity changes have also been revealed in patients with other psychiatric disorders, the King’s study found that these changes were more marked specifically in women who become unwell, potentially reflecting the emotional instability women experience during the course of the disorder.

Paola Dazzan, Professor of Neurobiology of Psychosis at King’s College London, said “We recently published another paper looking at the role of stress in postpartum psychosis, which found that higher levels of cortisol (the main stress hormone) in the third trimester of pregnancy predicted postpartum psychosis relapse. If subtle alterations in the brain’s executive network, and its interaction with other brain areas, were also detectable in pregnancy, these could offer vital clues to the development of postpartum psychosis. Potentially, this could enable us to intervene earlier, allowing clinicians to provide the best possible support for new mothers, before the onset of symptoms.”

The researchers are now planning to study how these brain scan changes are related to the interaction between the mothers and their babies, and also how the babies develop during their first years of life.

This research was funded by the Medical Research Foundation, with additional support from the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.

Professor Paola Dazzan’s postpartum psychosis research is funded by a gift in Will to the Medical Research Foundation, received in memory of a donor’s sister.

For further information, please contact Jack Stonebridge, Senior Communications Manager at the Medical Research Foundation