Adventures with enzymes at the interface of chemistry and biology

Professor Chris Schofield FRS will delve into fundamental research on chemical aspects of antibiotic biosynthesis and resistance. The lecture will focus on enzymes that cause reactions not possible with synthetic chemistry. The presentation will illustrate how this research has unveiled an unforeseen and therapeutically tractable regulatory mechanisms in humans and other organisms. Professor Schofield will make a compelling case that young researchers have ample opportunities to uncover unknown facets of the chemical aspects of biology.

Speaker bio

Chris Schofield pursued his undergraduate degree in chemistry at the University of Manchester Institute of Science and Technology (UMIST). He moved to Oxford for DPhil studies under the guidance of Jack Baldwin, focusing on the synthesis and biosynthesis of antibiotics. Following graduation, he became a Departmental Demonstrator in the Dyson Perrins Laboratory, subsequently being appointed as a Lecturer in Chemistry and Fellow of Hertford College, Oxford in 1990. In 1998 he became Professor of Chemistry and served as Head of Organic Chemistry from 2011 to 2021. He is a Fellow of the Royal Society and Head of Chemistry at the Ineos Oxford Institute for Antimicrobial Research.

His research group works at the interface of chemistry, biology and medicine. His research has opened new fields in antibiotic research, oxygen sensing and gene regulation in organisms, ranging from bacteria to plants and animals. His work has identified new opportunities for medicinal intervention that are being pursued by numerous academic and commercial laboratories.

 

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