PhD studentship in preclinical models of Alzheimer’s disease intervention

Award details

The goal of the project is to manipulate these pathways in a well-established rodent model of Alzheimer’s disease with a clinically approved compound and monitor changes in disease progression at the molecular, cellular, neuronal network and behavioural levels.

The project requires a good academic knowledge of molecular or cellular neuroscience and a genuine interest in understanding the mechanisms of brain disease using in vivo animal models. The PhD candidate will gain advanced skills in biochemical methods, confocal optical microscopy, EEG sleep recording and learning and memory paradigms.

This PhD project will be based at the Maurice Wohl Clinical Neuroscience Institute, offering state-of-the-art laboratories, an outstanding Nikon-sponsored microscopy imaging centre (Wohl Cellular Imaging Centre), and on-site animal husbandry facilities.

The Maurice Wohl hosts several labs working on mechanistic causes of dementia and is also the site chosen by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK for one of seven Dementia Research Institute Centres. Numerous events on the topic of dementia research are hosted through the year and provide an intellectually stimulating and supportive environment for the PhD students.

Supervisors

Dr Alessio Delogu

Professor Peter Giese

Award value

Fully funded for four years for Home students; international applicants must be ready to self-fund the difference in tuition fees and visa.

Eligibility criteria

Applicants should have (or be expected to obtain) a bachelor’s degree with 2:1 honours (or Overseas equivalent). A 2:2 degree may be considered only where applicants also offer a master’s with Merit.

Application process

On the ‘Choosing a programme’ page, please select Department of Basic and Clinical Neuroscience Research (Full-time).

In your application, you will be asked to include:

• Academic Transcripts – where applicable, academic transcripts must be submitted with the online admissions application
• Details of your qualifications – you will need to attach copies
• Details of previous employment – please include your CV
• A personal statement describing your interests and why you wish to apply for this project. Please include this as an attachment rather than using the text box.
• Academic References – all admissions applications require one supporting reference. If the applicant is relying on their referees to submit a reference directly to the College after they have submitted their admissions application, then the applicant must ensure that (1) their chosen referee is made aware of the funding deadline (i.e. 7 days from application deadline) and (2) that the reference needs to be sent from an institutional email address.

In the Funding section, please tick box 5 and include the following reference: (ADPG-IoPPN-PSCT25)

Please note there is no need to complete the Research Proposal section in your application as the project has already been set.

You are welcome to email Dr Alessio Delogu or Professor Peter Giese for more information regarding the project and studentship.

If you have any queries regarding the application process, please contact the Education support team at ioppn.pgr@kcl.ac.uk.

References must be received by the deadline for the applicant to be eligible. Only shortlisted applicants will be contacted.

Selection process

Interviews to take place on 6 March 2025.