Hypomagnesaemia, a deficiency in magnesium, is associated with an elevated risk for several non-communicable chronic diseases (NCDs) including metabolic syndrome, type II diabetes mellitus, atherosclerosis, hypertension, myocardial infarction, arrhythmia, hyperlipidaemia, premenstrual syndrome, osteoporosis (1, 5, 6, 9, 10, 14), and psychiatric disorders (6), including Alzheimer’s disease and attention deficit hyperactivity disorder (ADHD) (15).
Approximately 40% of patients with hypomagnesaemia will have coexisting hypokalaemia (1), and hypocalcaemia may also be present (6).
Secondary data analysis of NHANES 2001-2010 data showed that a higher intake of magnesium (from diet and supplements) was associated with a significantly lower odds ratio for the development of metabolic syndrome, overweight and obesity, elevated systolic blood pressure, a reduction in HDL cholesterol and an elevated C-reactive protein (16). Magnesium as a therapeutic agent has been described in pre-eclampsia and certain forms of arrhythmia (14), and in migraine headaches and asthma (15), though more data are needed to confirm clinical indication.