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Agamemnon (Agi) Grigoriadis

Professor Agamemnon (Agi) Grigoriadis

Professor of Bone and Cartilage Cell Biology

Research interests

  • Biomedical and life sciences

Biography

Professor Grigoriadis is a cell biologist interested in how bone and cartilage tissues are formed during embryonic development and in the post-natal remodelling skeleton, and how deregulated molecular mechanisms drive metabolic bone disease, in particular skeletal cancers. 

He obtained his PhD at the University of Toronto, identifying novel multipotent skeletogenic mesenchymal stem cell populations, and received a MRC Canada Fellowship for postdoctoral work at the IMP in Vienna where he established transgenic models of bone cancer and metabolic bone disease. 

His current group at King's uses pluripotent stem cell-based approaches to understand bone/cartilage lineage commitment during development and for generating defined populations for stem cell-based therapy of bone and cartilage disorders, and is identifying signalling pathways and novel therapeutic targets involved in osteosarcoma growth and metastasis using in vivo models.

    Research

    Well-defined gels
    Centre for Craniofacial & Regenerative Biology

    Our research goes beyond the mouth. If we understand how the entire face and head forms, we can repair damage and regenerate cells. If we unravel the causes of diseases, we can treat patients successfully. If we solve these problems, our discoveries will improve health worldwide.

    synthetic-biology
    RNA Biology

    RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.

    News

    New potential avenues for cancer therapies through RNA-binding proteins

    A new paper highlights the role of two RNA binding proteins – LARP4A and LARP4B – in the development of cancer

    RNA-binding proteins (cancer)

      Research

      Well-defined gels
      Centre for Craniofacial & Regenerative Biology

      Our research goes beyond the mouth. If we understand how the entire face and head forms, we can repair damage and regenerate cells. If we unravel the causes of diseases, we can treat patients successfully. If we solve these problems, our discoveries will improve health worldwide.

      synthetic-biology
      RNA Biology

      RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.

      News

      New potential avenues for cancer therapies through RNA-binding proteins

      A new paper highlights the role of two RNA binding proteins – LARP4A and LARP4B – in the development of cancer

      RNA-binding proteins (cancer)